AI Summary & Key Takeaways
AI InsightAs a result of quantitative structure-activity relationships of 2-(p-substituted-phenyl) benzoxazoles for C. albicans, it was found that hydrophobic, electronic or steric parameters were more significant when they were used in combined forms than they were used separately.
📌 3 Key Takeaways
Abstract
The antifungal active 2-(p-substitutcd-phenyl) benzoxazoles against C. albicans were studied in a QSAR (quantitative structureactivity relationships) work using the multiple regression method. Some of the hydrophobic , electronic ( F, R) and steric (MR, MW, Pr ) constants were used as physicochemical parameters. The correlation equations and the best equation obtained from regression analysis were given. As a result of quantitative structure-activity relationships of 2-(p-substituted-phenyl) benzoxazoles for C. albicans, it was found that hydrophobic, electronic or steric parameters were more significant when they were used in combined forms than they were used separately.
Özet
Candida albicans'a karşı antifungal etkili 2-(p-sübstitüe-fenil)- benzoxazol türevlerinin, çoklu regresyon metodu kullanılarak, kantitatif yapı-etki ilişkileri (QSAR) çalışılmıştır. Fizikokimyasal para metreler olarak bazı hidrofobik , elektronik ( F, R) ve sterik (MR, MW, Pr ) sabiteler kullanılmıştır. Regresyon analizleri sonucu ele geçen korelasyon denklemleri ve ideal denklem çalışmada verilmiş- tir. 2-(p-Sübstitüe-fenil) benzoksazol türevlerinin kantitatif yapı-etki ilişkileri incelendiğinde, C. albicans için hidrofobik, elektronik ve sterik parametrelerin tek tek kullanılmaları yerine, kombinasyonlarının oldukça dikkate değer sonuçlar verdiği saptanmıştır.