AI Summary & Key Takeaways
AI InsightAfter the purity control by TLG their chemical structures have been elucidated by IR, NMR and Elemental Analysis.The in vitro antituberculosis activity of all compounds were determined, and activity of compound 3 (2-(o-M.ethoxyphenyl) benzimidazole Hydrochloride) (MIC: 16.28 g/ml) has been found noteworthy.
📌 3 Key Takeaways
Abstract
In this research, ten 2', 4', 5-trisubstituted-2-phenyl-benzimidazoles have been prepared and four of them are original. These compounds were synthesized by heating 4-substituted-o-phenylenediamines and ortho and parasubstitutedbenzoic acids in the presence of polyphosphoric acid. After the purity control by TLG their chemical structures have been elucidated by IR, NMR and Elemental Analysis.The in vitro antituberculosis activity of all compounds were determined, and activity of compound 3 (2-(o-M.ethoxyphenyl) benzimidazole Hydrochloride) (MIC: 16.28 g/ml) has been found noteworthy.
Özet
Bu çalışmada, 4 tanesi orijinal, 10 adet 2', 4', 5-trisübstitüe-2- fenilbenzimidazol türevi bileşik, sentez edilmek istenen bileşiğe göre seçilen 4-sübstitüe-o-fenilendiamin ile orto ve parasübstitüebenzoik asitin polifosforik asit varlığında ısıtılması ile elde edilmişlerdir. Elde edilen bileşiklerin saflıkları İTK ile kontrol edildikten sonra, ergime dereceleri saptanmış ve yapıları IR, NMR, Elementel Analiz yöntemleri ile açıklanmıştır. İn vitro antitüberküloz etkileri saptanan bu bileşiklerden 3 numaralı 2-(o-Metoksifenil) benzimidazol hidroklorür (MİK: 16.28 g/ ml) ün etkisi dikkate değer bulunmuştur.