AI Summary & Key Takeaways
AI InsightSubstitution of the 2n d position of benzoxazole or its analogs is decisive for the activity whereas substitution of 5t h the position determines the intensity of the activity The comparison of the antimicrobial activities of the compounds with each other and with the standart antibiotics were mentioned and it was found that some of the compounds were more active than some of the antibiotics while the others possesed the same activity or less.
📌 3 Key Takeaways
Abstract
In this review, the antibacterial and antifungal activities of synthetic or semi-synthetic benzoxazole, benzimidazole, benzothiazole and oxazolo (4,5-b) pyridine derivatives were studied. The antimicrobial activity of these compounds are between 6.25 and 200 g / ml as M I C values. Substitution of the 2n d position of benzoxazole or its analogs is decisive for the activity whereas substitution of 5t h the position determines the intensity of the activity The comparison of the antimicrobial activities of the compounds with each other and with the standart antibiotics were mentioned and it was found that some of the compounds were more active than some of the antibiotics while the others possesed the same activity or less.
Özet
Bu derlemede, sentetik veya semisentetik olarak hazırlanan benzoksazol, benzimidazol, benzotiyazol ve oksazolo (4,5-b) piridin türevlerinin antibakteıiyel ve antifungal etkilen araştırılmıştır. İncelenen bileşiklerin, MİK değerleri 6.25-200 g/ ml arasında değişmektedir. Benzoksazol ve analoglarında 2. konumdan sübstitüsyonun etki şeklini yönlendiril ken, 5. konumdan sübstitüsyonun etki şiddeti üzerinde rolü olduğu görülmüştür. Bileşiklerin kendi aralarında ve diğer standart antibiyotiklerle etki kıyaslamaları ele alınarak bir kısmının test edilen antibiyotiklerle eşit, bazen de daha etkili oldukları bulunmuştur