Journals / Ankara Üniversitesi Eczacılık Fakültesi Dergisi / 2001 / Cilt: 30 - Sayı: 3

OXIDATIVE D A M A G E IN THE CENTRAL NERVOUS SYSTEM A ND PROTECTION BY MELATONIN

SANTRAL SİNİR SİSTEMİNİN OKSİDATİF HASARI VE MELATONİN TARAFINDAN KORUNMASI

Pages
47–62
Publication Date
2001-09-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The role of melatonin as an antioxidant agent and protection against central nervous system diseases was investigated in this review

📌 3 Key Takeaways

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Objective & Hypothesis:Melatonin was recently reported to be an effective free radical scavenger and antioxidant.
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Key Findings & Data:It is believed that melatonin scavenges the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical.
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Conclusion & Impact:The role of melatonin as an antioxidant agent and protection against central nervous system diseases was investigated in this review
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Anahtar Kelimeler Melatonin · Antioksidan · Serbest radikal

Abstract

Melatonin was recently reported to be an effective free radical scavenger and antioxidant. It is believed that melatonin scavenges the highly toxic hydroxyl radical, the peroxynitrite anion, and possibly the peroxyl radical. Also melatonin has been shown to reduce amyloid protein toxicity of Alzheimer's disease and oxidative damage in several models of parkinson's disease. The role of melatonin as an antioxidant agent and protection against central nervous system diseases was investigated in this review

Özet

Son zamanlarda melatoninin etkili bir serbest radikal yakalayıcısı ve antioksidan olduğu rapor edilmektedir. Melatoninin çok toksik olan hidroksil radikalini, peroksinitrit anyonunu ve büyük olasılıkla peroksil radikalini yakaladığına inanılmaktadır. Ayrıca melatoninin Alzheimer hastalığında amiloid protein toksisitesini düşürdüğü, Parkinson hastalığının çeşitli tiplerinde oksidatif hasarı azalttığı gösterilmiştir. Bu derlemede melatoninin antioksidan bir ajan olarak rolü ve santral sinir sistemi hastalıklarındaki koruyuculuğu araştırılarak sunulmuştur

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Cite This Article

ATEŞ-ALAGÖZ, Z., SÜZEN, S. (2001). OXIDATIVE D A M A G E IN THE CENTRAL NERVOUS SYSTEM A ND PROTECTION BY MELATONIN. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, Cilt: 30 - Sayı: 3, 47–62. https://ajindex.com/articles/38710

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