AI Summary & Key Takeaways
AI InsightIt is suggested that benzoxazole compounds with new scaffold may be synthesized, assayed for antibacterial activity and DNA gyrase inhibition, which mayresult in discovering lead compounds and reveal mechanism of action of these derivatives
📌 3 Key Takeaways
Abstract
Molecular modelling studies were also carried out. Pharmacophore models were generated with best docked conformations of biologically active fluroquinolone antibiotics into DNA gyrase of S. aureus. New benzoxazole scaffold were designed which maps to the best pharmacophore model. It is suggested that benzoxazole compounds with new scaffold may be synthesized, assayed for antibacterial activity and DNA gyrase inhibition, which mayresult in discovering lead compounds and reveal mechanism of action of these derivatives
Özet
Yapılan moleküler modelleme çalışmalarında bazı çok etkili florokinolon antibiyotikleri ve S. aureus’a ait DNA giraz enzimi kullanılmış, etkiden sorumlu olduğu düşünülen farmakofor yapı ortaya konulmuştur. Bu farmakofor modele uyabilecek iskelete sahip tasarlanan yeni benzoksazol türevi bileşiklerin sentezlenmesi, antibakteriyel ve DNA giraz inhibisyon etkilerinin incelenmesi ile birlikte etki mekanizmalarını aydınlatabilecek çalışmaların yürütülmesi önerilmiştir