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Journals / Van Veterinary Journal / 2021 / Cilt: 32 - Sayı: 3

The Effect of Vitamin C on Oxidant and Antioxidant Parameters in Anthrax Vaccine Administered Cattle

Şarbon Aşısı Uygulanan Sığırlarda Vitamin C’nin Oksidan ve Antioksidan Parametreler Üzerine Etkisi

Ertan DOĞAN
Oğuz MERHAN
Dinçer ERDAĞ
Ege KARAMANCI
Kadir BOZUKLUHAN
Ali Nazmi Can DOĞAN
Pages
109–113
Publication Date
2021-11-26
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that the MDA and NO levels significantly increased (P 0.05) compared to the vaccine group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, the effects of Vitamin C on oxidative stress in anthrax vaccinated cattle were investigated.
📊
Key Findings & Data:The research was performed on 40 healthy cattle without any race and gender difference, and aged 6-8 months that were not anthrax vaccinated.
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Conclusion & Impact:It was found that the MDA and NO levels significantly increased (P 0.05) compared to the vaccine group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:C vitamini · lipit peroksidasyonu · oksidatif stres

Abstract

In this study, the effects of Vitamin C on oxidative stress in anthrax vaccinated cattle were investigated. The research was performed on 40 healthy cattle without any race and gender difference, and aged 6-8 months that were not anthrax vaccinated. The cattle were divided into four equal groups. The first group was determined as the control group. 1 ml anthrax vaccine was administered to the second group, 1 ml anthrax vaccine and 5 mg/kg dose of vitamin C was administered to the third group, and vitamin C was administered to the fourth group at a dose of 5 mg/kg. Blood collection were collected and serum samples were extracted just before the vaccination and drug administration (0th day) and on the 2nd, 14th and 28th days after the administration. Nitric Oxide (NO), Malondialdehyde (MDA), Superoxide Dismutase (SOD) and Catalase (CAT) levels of serum samples were evaluated. It was found that the MDA and NO levels significantly increased (P 0.05) compared to the vaccine group. It can be asserted that the use of vitamin C in combination with anthrax vaccine in cattle would be beneficial in terms of reducing oxidative stress.

Özet

Bu çalışmada şarbon aşısı uygulanan sığırlarda oksidatif stres üzerine Vitamin C’nin etkileri araştırıldı. Araştırma, şarbon aşısı yapılmamış, ırk ve cinsiyetleri farklı, yaşları 6-8 ay olan 40 adet sağlıklı sığırlarda yürütüldü. Sığırlar dört eşit gruba ayrıldı. Birinci grup kontrol grubu olarak tutuldu. İkinci gruba 1 ml şarbon aşısı, üçüncü gruba 1 ml şarbon aşısı ve 5 mg/kg dozda C vitamini, dördüncü gruba ise 5 mg/kg dozda C vitamini uygulandı. Aşı ve ilaç uygulanmadan hemen önce (sıfırıncı gün) ve uygulama sonrası 2., 14. ve 28. günlerde kan alınarak serumları çıkartıldı. Serum örneklerinde Nitrik Oksit (NO), Malondialdehit (MDA), Süperoksit Dismutaz (SOD) ve Katalaz (CAT) düzeyleri ölçüldü. Aşı grubunda 2., 14. ve 28. günlerde MDA ve NO miktarının kontrol grubuna göre önemli oranda arttığı (P0.05) miktarda azaldığı belirlendi. Sığırlarda şarbon aşısı ile birlikte C vitamininin kullanılması oksidatif stresi azaltması açısından faydalı olacağı ileri sürülebilir.

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Cite This Article

DOĞAN, E., MERHAN, O., ERDAĞ, D., KARAMANCI, E., BOZUKLUHAN, K., DOĞAN, A. N. C. (2021). The Effect of Vitamin C on Oxidant and Antioxidant Parameters in Anthrax Vaccine Administered Cattle. Van Veterinary Journal, Cilt: 32 - Sayı: 3, 109–113. https://ajindex.com/articles/383737

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