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Journals / Journal of the Turkish-German Gynecological Association / 2007 / Cilt: 8 - Sayı: 1

Normal ve yardımla üreme teknolojileri sonrası doğan çocukların karşılaştırılması: Literatür taraması ve kendi sonuçlarımız

Comparison between children born after natural conception and those born after assisted reproduction technology: A review of the literature and results from our survey

Mohamad Eid HAMMADEH
Kubilay ERTAN
Peter ROSENBAUM
Werner SCHMIDT
Pages
94–111
Publication Date
2022-10-18
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Many studies have concluded that IVF/ICSI pregnancies carry an increased risk for multiplicity, perinatal mortality, preterm birth and low birth weight in comparison with pregnancies after spontaneous conception.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Many studies have concluded that IVF/ICSI pregnancies carry an increased risk for multiplicity, perinatal mortality, preterm birth and low birth weight in comparison with pregnancies after spontaneous conception.
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Key Findings & Data:Others have investigated the incidence of congenital malformations in IVF/ICSI conceptions and reported a possible increase in the incidence of central nervous system defects, chromosomal abnormalities, urogenital abnormalities and limb malformations.
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Conclusion & Impact:In this paper, no increase in the malformation risk of infants born after ART treatment is defended.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Many studies have concluded that IVF/ICSI pregnancies carry an increased risk for multiplicity, perinatal mortality, preterm birth and low birth weight in comparison with pregnancies after spontaneous conception. Others have investigated the incidence of congenital malformations in IVF/ICSI conceptions and reported a possible increase in the incidence of central nervous system defects, chromosomal abnormalities, urogenital abnormalities and limb malformations. Concerns have been raised that Assisted reproduction technology (ART) might increase the malformation rate in offspring, particularly after intracytoplasmic sperm injection (ICSI). However, other studies have concluded that there is no evidence of an increase in the occurrence of malformations.The aim of this study is to summarize the present knowledge concerning male formation after ART in comparison to the spontaneously conceived children and whether this increased risk could be related to ART procedures or whether it is mainly related to parental characteristics. For this study the literature and results from a survey as well as our data we analyzed. A total of 151 infants were born after ART at our department, among which one case of trisomy (0.66%) and one case of Potter syndrome (0.66%) were observed. In this paper, no increase in the malformation risk of infants born after ART treatment is defended.

Özet

Spontan gebeliklerle karşılaştırıldığında, IVF/ICSI gebeliklerinde çoğul gebelik, perinatal mortalite, erken doğum ve düşük doğum ağırlığı riskinin arttığı birçok araştırmanın vardığı ortak sonuçtur. Bazı çalışmalarda IVF/ICSI gebeliklerinde konjenital bozukluklar incelenmiş ve merkezi sinir sistemi, kromozomal, ürogenital ve ekstremite gelişim anomalilerinde olası bir artış rapor edilmiştir. Yardımla üreme teknolojilerinden (YÜT) özellikle intrasitoplazmik sperm enjeksiyonu (ICSI) sonrasında, yenidoğanda malformasyon oranının arttığına dair tereddütler bulunmaktadır. Ancak, farklı çalışmalar malformasyonların artışı ile ilgili kesin kanıtlar olmadığı sonucuna varmışlardır.Bu çalışmanın amacı, YÜT’ten sonra oluşabilecek malformasyonların spontan gebelikler ile karşılaştırılması amacıyla güncel bilgileri özetlemek; bu risk artışının YÜT uygulamalarına mı? yoksa öncelikle ebeveyn özelliklere mi? bağlı olduğunu araştırmaktır. Bu çalışma için literatür taraması yapılmış ve kendi verilerimizle birlikte başka bir araştırmanın sonuçları analiz edilmiştir. Bölümümüzde YÜT sonrası, içlerinde bir trizomi (% 0.66) ve bir Potter sendromu (% 0.66) vakası da olmak üzere 151 çocuk dünyaya gelmiştir.Bu makalede, YÜT sonucunda doğan çocuklarda malformasyon riskinde artış olmadığı savunulmaktadır.

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Cite This Article

HAMMADEH, M. E., ERTAN, K., ROSENBAUM, P., SCHMIDT, W. (2022). Normal ve yardımla üreme teknolojileri sonrası doğan çocukların karşılaştırılması: Literatür taraması ve kendi sonuçlarımız. Journal of the Turkish-German Gynecological Association, Cilt: 8 - Sayı: 1, 94–111. https://ajindex.com/articles/567966

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