Intrathoracic Castleman disease

Multimodal treatment, including chemotherapy, is recommended in patients with a multicentric form of the disease, and they should be followed closely.

📌 3 Key Takeaways

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Objective & Hypothesis:To analyze patients with Castleman disease who were diagnosed by surgery.

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Key Findings & Data:Materials and methods: We retrospectively investigated the postoperative pathological records of operations performed between January 1992 and December 2012 in our hospital.

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Conclusion & Impact:Multimodal treatment, including chemotherapy, is recommended in patients with a multicentric form of the disease, and they should be followed closely.

🔬Design:Research Article

📍Scope:2012 Verileri

⚙️Variables:Key words: Castleman disease · mediastinum · lung

Abstract

To analyze patients with Castleman disease who were diagnosed by surgery. Materials and methods: We retrospectively investigated the postoperative pathological records of operations performed between January 1992 and December 2012 in our hospital. Files of 19 patients with the diagnosis of Castleman disease were analyzed. Results: There were 13 male and 6 female patients with a mean age of 40.1 ± 11.4 (range: 20-57) years. Fifteen thoracotomies and 3 video-assisted thoracoscopies, 12 on the right side and 6 on the left side, and 1 mediastinoscopy were performed. Biopsies and mass excisions were performed in 2 and 17 cases, respectively. Histopathological findings were hyaline vascular-type (n = 16), plasma cellular-type (n = 2), and hyaline vascular plus plasma cellular-type (n = 1) Castleman disease. Conclusion: Castleman disease can occur in all areas of the thorax, but the mediastinum and hilum are the most common locations. Surgical excision is the best method of diagnosis and treatment. Complete excision is curative for local forms of the disease. However, complete excision may not be possible at all times due to local invasion and hypervascularization. Multimodal treatment, including chemotherapy, is recommended in patients with a multicentric form of the disease, and they should be followed closely.

Özet

To analyze patients with Castleman disease who were diagnosed by surgery. Materials and methods: We retrospectively investigated the postoperative pathological records of operations performed between January 1992 and December 2012 in our hospital. Files of 19 patients with the diagnosis of Castleman disease were analyzed. Results: There were 13 male and 6 female patients with a mean age of 40.1 ± 11.4 (range: 20-57) years. Fifteen thoracotomies and 3 video-assisted thoracoscopies, 12 on the right side and 6 on the left side, and 1 mediastinoscopy were performed. Biopsies and mass excisions were performed in 2 and 17 cases, respectively. Histopathological findings were hyaline vascular-type (n = 16), plasma cellular-type (n = 2), and hyaline vascular plus plasma cellular-type (n = 1) Castleman disease. Conclusion: Castleman disease can occur in all areas of the thorax, but the mediastinum and hilum are the most common locations. Surgical excision is the best method of diagnosis and treatment. Complete excision is curative for local forms of the disease. However, complete excision may not be possible at all times due to local invasion and hypervascularization. Multimodal treatment, including chemotherapy, is recommended in patients with a multicentric form of the disease, and they should be followed closely.

Keywords

Key words: Castleman disease mediastinum lung surgery

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Cite This Article

BIÇAKÇIOĞLU, P., GÜLHAN, S. Ş. E., ACAR, L. N., AĞAÇKIRAN, Y., ÖZKARA, Ş., KAYA, S., KARAOĞLANOĞLU, N. (2014). Intrathoracic Castleman disease. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 2, 197–202. https://ajindex.com/articles/383228

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References (13)

Madan R, Chen JH, Dickenson BT, Jacobson F, Hunsaker A. The spectrum of Castleman’s disease: Mimics, radiologic pathologic correlation and role of imaging in patient management. Eur J Rad 2012; 81: 123–131.
Castleman B, Towne VW. Case records of the Massachusetts General Hospital: Case No. 40231. N Eng J Med 1954; 250: 1001–1005.
Castleman B, Iverson L, Menendez VP. Localized mediastinal lymph node hyperplasia resembling thymoma. Cancer 1956; 9: 822–830.
Yeh CM, Chou CM, Wong LC. Castleman’s disease mimicking intrapulmonary malignancy. Ann Thorac Surg 2007; 84: 6–7.
Bonekamp D, Horton KM, Hruban RH, Fishman EK. Castleman disease: the great mimic. Radiographics 2011; 31: 1793–1807.
Fındık G, Kalaycıoğlu S, Aydoğdu K, Ağaçkıran Y, Karaoğlanoğlu N, Taştepe İ, Kaya S. Toraks yerleşimli Castleman hastalığında tedavi ve prognoz: 8 olgunun analizi. Solunum Hastalıkları 2009; 20: 68–71 (in Turkish). Cronin DM, Warnke RA. Castleman disease: an update on classification and the spectrum of associated lesions. Adv Anat Pathol 2009; 16: 236–246.
Shetty S, Brenes RA, Panait L, Sanchez JA. Video assisted thoracoscopic resection of a posterior mediastinal Castleman’s tumor. J Cardiothorac Surg 2011; 6: 113–116.
Danon AD, Krishnan J, Frizzera G. Morphoimmunophenotypic diversity of Castleman’s disease, hyaline vascular type: with emphasis on stroma-rich variant and a new pathogenetic hypothesis. Virchows Arch A Pathol Anat Histopathol 1993; 20: 636 –647. Saeed-Abdul-Rahman I, Al-Amri AM. Castleman disease. Korean J Hematol 2012; 47: 163–177.
Bicakcioglu P, Aydin E, Celik A, Demirag F, Karaoglanoglu N. Primary classical hemangiopericytomas of thorax. Ann Thorac Surg 2012; 94: 255–259.
Johkoh T, Müller NL, Ichikado K, Nishimato N, Yoshizaki K, Honda O, Tomiyama N, Naitoh H, Nakamura H, Yamamoto S. Intrathoracic multicentric Castleman disease: CT findings in 12 patients. Radiology 1998; 209: 477–481.
Gunluoglu G, Olcmen A, Sokucu SN, Akin H, Dincer I. Intrapulmonary-located Castleman’s disease, which was surgically resected without pulmonary resection. Ann Thorac Cardiovasc Surg 2011; 17: 580–583.
Aydemir B, Okay T, Imamoglu O, Sahin S, Dogusoy I. Preoperative embolization in mediastinal Castleman’s disease. Thorac Cardiovasc Surg 2010; 58: 496–498.
Taştepe İ, Demircan S, Kuzucu A, Karaoğlanoğlu N, Kürkçüoğlu C, Liman ŞT, Ünlü M, Çetin G. Castleman hastalığı: dev lenf nodu hiperplazisi. GKD Cer Derg 1996; 4: 135–137 (in Turkish). Birel FD, Ernam D, Sönmez ÖS, Ökten F, Gülhan E