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Journals / Turkish Journal of Family Medicine and Primary Care / 2015 / Cilt: 9 - Sayı: 1

Serum Melatonin Seviyesi ile İnfantil Kolik İlişkisi

The Relationship of Serum Melatonin Levels With Infantile Colic

Nihat CENGİZ
Salim ÖZENÇ
Necati BALAMTEKİN
Erkan SARI
Emin Özgür AKGÜL
Turgut TOPAL
HALİL İBRAHİM AYDIN
Mehmet SALDIR
Ahmet Emin KÜREKÇİ
Pages
10–15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The results of our study support the hypothesis that the decrease of melatonin causes infantile colic.

📌 3 Key Takeaways

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Objective & Hypothesis:Background: The serotonin concentration peaks at night which causes intestinal cramps.
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Key Findings & Data:While there are only serotonin circadian rhythms during birth, the melatonin circadian rhythms begin after 3rd month.
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Conclusion & Impact:The results of our study support the hypothesis that the decrease of melatonin causes infantile colic.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background: The serotonin concentration peaks at night which causes intestinal cramps. Both serotonin and melatonin have circadian rhythms and they peak at night. While there are only serotonin circadian rhythms during birth, the melatonin circadian rhythms begin after 3rd month. It is argued that serotonin is high and melatonin is low for the infants who have colic, yet there are no studies proving this argument. Methods: The study population is chosen with a developed random sampling method among 50 infants who have infantile colic and 66 infant as healthy control group. Results: The melatonin levels of the blood samples which were taken from both groups at 09.00 am and also from 20 infants with infantile colic blood samples were taken 09.00 pm.were compared; The melatonin level of the infants with infantile colic is found to be lower than the control group (p: 0.014). The evening melatonin levels in babies with infantile colic were significantly higher than morrning levels (p:0.001). Conclusions: Serum melatonin levels of the study group were found to be lower and also significant statistically . The results of our study support the hypothesis that the decrease of melatonin causes infantile colic.

Özet

Giriş: Serotonin konsantrasyonu akşamları pik yapar, bu intestinal kramplara neden olur. Hem serotoninin hem de melatoninin sirkadiyan ritmi vardır ve akşamları pik yapar. Doğumda sadece serotoninin sirkadiyan ritmi varken melatoninin sirkadiyan ritmi 3.ayda başlar. Kolikli bebeklerde serotoninin yüksek, melatoninin düşük olduğu hipotezleri ileri sürülmüş ama bu konuda bebeklerde çalışmalar yapılmamıştır. Yöntem:Çalışma popülasyonu; geliştirilen rastgele örnekleme yöntemi ile 50 infantil kolikli ve 66 normal ağlayan bebek arasından seçildi. Bulgular: İnfantil kolikli ve sebepsiz ağlayan bebeklerde sabah 09:00da alınan kanda serum melatonin seviyeleri ile infantil kolikli 20 bebekte sabah 09:00 ve akşam 21:00deki serum melatonin seviyeleri karşılaştırıldığında; infantil kolikli bebeklerin serum melatonin seviyeleri sebepsiz ağlayan bebeklerin serum melatonin seviyelerinden istatistikî olarak anlamlı düşük bulundu (p:0.014). İnfantil kolikli bebeklerde sabah ve akşam melatonin seviyeleri karşılaştırıldı, akşam ki melatonin seviyeleri istatistikî olarak anlamlı yüksek bulundu (p :0.001). Sonuç: Çalışma grubumuzun serum melatonin seviyeleri istatistiksel olarak anlamlı derecede düşük bulundu. Bu sonuçlarımız melatonin seviyesinin azalmasının infantil kolik gelişmesine sebep olduğu hipotezini desteklemektedir.

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Cite This Article

CENGİZ, N., ÖZENÇ, S., BALAMTEKİN, N., SARI, E., AKGÜL, E. Ö., TOPAL, T., AYDIN, H. İ., SALDIR, M., KÜREKÇİ, A. E. (2015). Serum Melatonin Seviyesi ile İnfantil Kolik İlişkisi. Turkish Journal of Family Medicine and Primary Care, Cilt: 9 - Sayı: 1, 10–15. https://ajindex.com/articles/371393

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