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Journals / Turkish Journal of Endocrinology and Metabolism / 2016 / Cilt: 20 - Sayı: 4

Orta Yaş Erkeklerde Seks Hormonları ve Alt Üriner Sistem Semptomları Arasındaki İlişki

Associations Between Sex Hormones and Lower Urinary Tract Symptoms in Middle-aged Men

Yasemin BUDAK ÜSTÜNDAĞ
Kağan HUYSAL
Erkan KARADAĞ
Hakan DEMİRCİ
Muhammet GUZELSOY
Soner COBAN
Pages
123–126
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

E2 receptors located in the prostate tissue may take part in the development of benign prostatic hyperplasia.

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The aim of this study was to investigate the association between serum sex hormone levels and lower urinary tract symptoms in men.
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Key Findings & Data:Material and Method: Forty-nine men with lower urinary tract symptoms aged 25-45 years (mean: 37.9±2.0 years) and 25 healthy men aged 25-45 years (mean: 35.9±2.0 years) as controls participated in this study.
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Conclusion & Impact:E2 receptors located in the prostate tissue may take part in the development of benign prostatic hyperplasia.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Purpose: The aim of this study was to investigate the association between serum sex hormone levels and lower urinary tract symptoms in men. Material and Method: Forty-nine men with lower urinary tract symptoms aged 25-45 years (mean: 37.9±2.0 years) and 25 healthy men aged 25-45 years (mean: 35.9±2.0 years) as controls participated in this study. Estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone, dehydroepiandrosterone sulfate, insulin-like growth factor-binding protein 3 (IGFBP3), insulin-like growth factor -1 (IGF1), and sex hormone-binding globulin levels were measured using commercially available assay kits. All participants were asked to complete the International Prostate Symptom Score questionnaire. Results: Demographic data were similar between patients and controls. Among the sex steroids studied, only FSH and E2 showed a statistically significant association with lower urinary tract symptoms (p<0.05). Besides, neither IGF1 nor IGFBP3 were associated with lower urinary tract symptoms. Discussion: Excess E2 may play an important role in the occurrence of lower urinary tract symptoms. E2 receptors located in the prostate tissue may take part in the development of benign prostatic hyperplasia.

Özet

Amaç: Bu çalışmanın amacı erkeklerde serum seks hormon seviyeleri ve alt üriner sistem semptomları arasındaki ilişkiyi incelemektir. Gereç ve Yöntem: Alt üriner sistem semptomu olan 25-45 yaş arası (ortalama: 37,9±2,0 yıl) 49 erkek ve aynı yaş aralığında (ortalama: 35,9±2,0 yıl) 25 kontrol olgusu çalışmada yer aldı. Estradiol (E2), folikül uyarıcı hormon (FSH), luteinleştirici hormon, dehidroepiandrosteron sülfat, insülin benzeri büyüme faktörü bağlayıcı protein-3 (IGFBP3), insülin benzeri büyüme faktörü-1 (IGF1) ve seks hormonu bağlayıcı globulin ölçümleri yapıldı. Tüm katılımcılar Uluslararası Prostat Semptom Skoru anketini doldurdular. Bulgular: Hasta ve kontrol grubuna ait demografik veriler benzerdi. Çalışılan hormonlardan FSH ve E2 değerleri alt üriner sistem semptom skorları ile anlamlı korelasyon gösterdi (p<0,05). IGF1 ve IGFBP3 sonuçları alt üriner sistem semptomları ile ilişkili bulunmadı. Tartışma: Estradiol yüksekliğinin alt üriner sistem semptomlarının görülmesinde etkili bir rolü olabilir. Prostat E2 reseptörleri benign prostat hiperplazisi gelişmesinde rol alabilir.

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Cite This Article

ÜSTÜNDAĞ, Y. B., HUYSAL, K., KARADAĞ, E., DEMİRCİ, H., GUZELSOY, M., COBAN, S. (2016). Orta Yaş Erkeklerde Seks Hormonları ve Alt Üriner Sistem Semptomları Arasındaki İlişki. Turkish Journal of Endocrinology and Metabolism, Cilt: 20 - Sayı: 4, 123–126. https://ajindex.com/articles/370837

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