Serum native thiol, total thiol, and disulfide levels were measured for all subjects.RESULTS: Serum total thiol and native thiol levels in the ESRD patients were significantly lower than those in the controls (P
📌 3 Key Takeaways
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Objective & Hypothesis:OBJECTIVE: We aimed to evaluate thiol/disulfide homeostasis as an oxidative stress parameter in end-stage renal disease patients receiving different substitutive therapies.MATERIAL and METHODS: Twenty-four renal transplantation (46.2±8.1 years), 24 peritoneal dialysis (47.8±8.5 years), and 25 hemodialysis patients (45.7±16.0 years), and 24 healthy controls (47.6±8.1 years) were included.
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Key Findings & Data:OBJECTIVE: We aimed to evaluate thiol/disulfide homeostasis as an oxidative stress parameter in end-stage renal disease patients receiving different substitutive therapies.MATERIAL and METHODS: Twenty-four renal transplantation (46.2±8.1 years), 24 peritoneal dialysis (47.8±8.5 years), and 25 hemodialysis patients (45.7±16.0 years), and 24 healthy controls (47.6±8.1 years) were included.
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Conclusion & Impact:Serum native thiol, total thiol, and disulfide levels were measured for all subjects.RESULTS: Serum total thiol and native thiol levels in the ESRD patients were significantly lower than those in the controls (P
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
OBJECTIVE: We aimed to evaluate thiol/disulfide homeostasis as an oxidative stress parameter in end-stage renal disease patients receiving different substitutive therapies.MATERIAL and METHODS: Twenty-four renal transplantation (46.2±8.1 years), 24 peritoneal dialysis (47.8±8.5 years), and 25 hemodialysis patients (45.7±16.0 years), and 24 healthy controls (47.6±8.1 years) were included. Serum native thiol, total thiol, and disulfide levels were measured for all subjects.RESULTS: Serum total thiol and native thiol levels in the ESRD patients were significantly lower than those in the controls (P
Özet
AMAÇ: Çalışmada son dönem böbrek yetmezliği hastalığı için farklı renal replasman tedavisi alan hastalarda bir oksidatif stres belirteci olarak tiol/disülfit dengesinin araştırılması amaçlanmıştır.GEREÇ ve yÖNTEMLER: Yirmi dört böbrek nakli yapılmış (46,2±8,1 yaş), 25 hemodiyaliz (45,7±16,0 yaş) ve 24 periton diyalizi (47,8±8,5 yaş) hastaları ile 24 sağlıklı kontrol (47,6±8,1 yaş) çalışmaya dahil edildi. Tüm olgularda nativ tiyol, total tiyol ve disülfit seviyeleri ölçüldü.BULGULAR: Hastalarda kontrol grubu ile karşılaştırıldığında total tiyol ve nativ tiyol seviyeleri anlamlı olarak düşüktü (p
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Cite This Article
EREL, Ö., ALIŞIK, M., KAHVECİOĞLU, S., BUDAK, Y. Ü., CELİK, H. (2022). Serum Thiol/Disulfide Homeostasis in Hemodialysis, Peritoneal Dialysis, and Renal Transplantation Patients. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, Cilt: 26 - Sayı: 1, 105–110. https://ajindex.com/articles/654991
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