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Journals / Toraks Dergisi / 2005 / Cilt: 6 - Sayı: 3

Lung cancer obscured by endobronchial aspergillosis and effect of topical amphotericin B and oral itraconazole

Endobronşiyal aspergillozis ile gizli akciğer kanseri ve topikal amfoterisin B ile oral itrakonazolün etkinliği

Melih BÜYÜKŞİRİN
Gülru POLAT
Adnan USALAN
Gülcan ÜRPEK
MEHMET UFUK YILMAZ
Zekiye AYDOĞDU
Gültekin TİBET
Pages
267–270
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Two cures of chemotherapy were administered and later on we were informed that he had died.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:A 38-year-old man, complaining of cough and dyspnea, applied to our hospital.
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Key Findings & Data:Complete atelectasis of the right lung was observed on chest ray.
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Conclusion & Impact:Two cures of chemotherapy were administered and later on we were informed that he had died.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Erkek · Aspergilloz · Ölümle sonuçlanma

Abstract

A 38-year-old man, complaining of cough and dyspnea, applied to our hospital. Complete atelectasis of the right lung was observed on chest ray. In fiberoptic broncoscopy, the right main bronchus just before the division of the upper lobe was occluded by a vegetative lesion covered by necrotic material. In the forceps biopsy specimen, aspergillus hyphea were observed within the necrotic debris and fibrin. The thorax computerized tomography (CT) showed tumoral lesion and thoracotomy was planned for diagnosis and treatment. But, in the bronchoscopic biopsy specimen of the mucosa of the main bronchus, aspergillus tissue invasion was identified and thoracotomy was postponed. Weekly endobronchial amphotericin B by fiberoptic bronchoscope and oral itraconazole were administered. After three weeks, bronchoscopic biopsy was repeated and revealed no aspergillus hyphae but pulmonary carcinoma was identified. According to the control thorax CT, the tumoral lesion was determined to be unresectable. The patient was planned to receive chemoradiotherapy. Two cures of chemotherapy were administered and later on we were informed that he had died.

Özet

Otuz sekiz yaşında erkek olgu öksürük ve dispne yakınmasıyla hastanemize başvurdu. Göğüs radyografisinde sağ akciğerde total atelektazi izlendi. Fiberoptik bronkoskopisinde (FOB), sağ ana bronşun, üst lob ayrımından hemen önce üzeri nekrotik materyalle kaplı vejetan kitleyle tam tıkalı olduğu görüldü. Forseps biyopsi materyalinde nekrotik debris içinde aspergillus hifleri izlendi. Toraksın bilgisayarlı tomografisinde (BT) tümöral lezyon izlendi. Tanı ve tedavi amaçlı torakotomi planlandı; ancak, ana bronştan alınan mukoza biyopsisinde aspergillus doku invazyonu izlenmesi nedeniyle torakotomi ertelendi. FOB yoluyla haftalık endobronşiyal amfoterisin B ve oral itrakonazol tedavisi başlandı. Üç hafta sonra bronkoskopik biyopsi tekrarlandı; aspergillus hifleri izlenmedi, fakat akciğer karsinomu saptandı. Kontrol toraks BT’sinde tümöral lezyonun anrezektabl olduğu görüldü. Olguya kemoradyoterapi uygulanmasına karar verildi. İki kür kemoterapi sonrası olgunun eksitus olduğu öğrenildi.

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Cite This Article

BÜYÜKŞİRİN, M., POLAT, G., USALAN, A., ÜRPEK, G., YILMAZ, M. U., AYDOĞDU, Z., TİBET, G. (2005). Lung cancer obscured by endobronchial aspergillosis and effect of topical amphotericin B and oral itraconazole. Toraks Dergisi, Cilt: 6 - Sayı: 3, 267–270. https://ajindex.com/articles/368093

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