SavedAdd your journal

Journals / Toraks Dergisi / 2006 / Cilt: 7 - Sayı: 2

Cardiac troponin levels in COPD cases

KOAH'lı olgularda kardiyak troponin düzeyleri

FİGEN DEVECİ
Teyfik TURGUT
TUNCER TUĞ
Gamze KIRKIL
Suat TÜRKOĞLU
Mehmet Hamdi MUZ
Pages
95–100
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We determined that serum troponin I levels increased in COPD attacks, but have no relation between pulmonary functions and oxygenation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:It is determined that cardiac troponin (CT) levels that is specific marker for myocardial injury, can increase in COPD attacks.
📊
Key Findings & Data:Demographic characteristics, PFP, ABA, electrocardiographic (ECG) and echocardiographic properties of 27 cases with COPD attack (group 1) and 13 stabilized COPD (group 2) and 10 healthy controls cases were determined.
💡
Conclusion & Impact:We determined that serum troponin I levels increased in COPD attacks, but have no relation between pulmonary functions and oxygenation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Solunum fonksiyon testleri · Kan gazı analizi · Troponin

Abstract

It is determined that cardiac troponin (CT) levels that is specific marker for myocardial injury, can increase in COPD attacks. We aimed to investigate the serum CT levels of acute and stabilized COPD cases, and relation between pulmonary function parameters (PFP) and arterial blood analyses (ABA) with CT. Demographic characteristics, PFP, ABA, electrocardiographic (ECG) and echocardiographic properties of 27 cases with COPD attack (group 1) and 13 stabilized COPD (group 2) and 10 healthy controls cases were determined. Serum troponin I (sTnI) and creatinin cinase-MB levels of all cases were evaluated. Levels above 0.5 ng/ml for sTnI were accepted as “high levels”. SaO2, and FEV1/ FVC ratio were significantly lower in group 1 than group 2 (p=0.000, p=0.029, respectively). sTnI levels were high in group 1 compared with group 2 (p=0.017) and 3 (p=0.000), and sTnI levels were statistically high in group 2 compared with group 3 (p=0.000). sTnI levels were above 0.5 ng/ml in 9 cases of group 1, no elevation was seen in group 2. Seven of 9 cases had pathological ECG properties (ST depression, ST elevation, T changes, block). No relation was observed between sTnI levels and PFP, ABA. We determined that serum troponin I levels increased in COPD attacks, but have no relation between pulmonary functions and oxygenation.

Özet

Miyokardiyal hasarın gösterilmesinde spesifik bir belirteç olan kardiyak troponin (kTn) düzeyleri KOAH ataklarında da yükselebilmektedir. Çalışmamızda akut ve stabil dönemdeki KOAH’lı olgularda serum kTn düzeylerinin belirlenmesi, solunum fonksiyon parametreleri ve arteryel kan gazları (AKG) ile olan ilişkisinin araştırılması amaçlanmıştır. Atak (n=27, grup 1) ve stabil (n=13, grup 2) dönemdeki KOAH ile sağlıklı kontrol (n=10, grup 3) olgularında solunum fonksiyon testleri (SFT), elektrokardiyografi (EKG), ekokardiyografi ve AKG analizleri yapılarak serum troponin I (sTnI) ve kreatin kinaz-MB değerleri ölçüldü. sTnI için 0.5 ng/ml üzerindeki değerler “yüksek troponin düzeyi” olarak kabul edildi. Arteryel oksijen satürasyonu ve FEV1/FVC oranları grup 1’de grup 2’ye göre anlamlı olarak düşüktü (sırasıyla p=0.000, p=0.029). sTnI düzeyi grup 1’de grup 2 (p=0.017) ve grup 3’e (p=0.000) göre ve grup 2’de grup 3’e göre anlamlı olarak yüksekti (p=0.000). Grup 1’de 9 olguda sTnI düzeyleri 0.5 ng/ml’nin üzerinde iken grup 2’deki hiçbir olguda yükseklik bulunmadı. Bu 9 olgunun 7’sinde en az bir EKG bulgusu olduğu görüldü. sTn düzeyleri ile SFT ve AKG değerleri arasında ilişki saptanmadı. Sonuç olarak sTn düzeylerinin özellikle KOAH atak dönemlerinde yüksek olduğu görülmüş olup, solunum fonksiyonları ve oksijenasyon ile ilişkili olmadığı düşünülmüştür.

🔖

Cite This Article

DEVECİ, F., TURGUT, T., TUĞ, T., KIRKIL, G., TÜRKOĞLU, S., MUZ, M. H. (2006). Cardiac troponin levels in COPD cases. Toraks Dergisi, Cilt: 7 - Sayı: 2, 95–100. https://ajindex.com/articles/367936

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Pauwels RA. National and international guidelines for COPD: the need for evidence. Chest 2000;117 (Suppl 2):20s-2s
  2. Eriş GB, Kaya A, Acıcan T, Bartu SS. KOAH’da pulmoner hipertansiyon ve kor pulmonale. In: Bartu SS, Acıcan T; eds. Güncel bilgiler ışığında kronik obstrüktif akciğer hastalığı. I. baskı Ankara: Bilimsel Tıp Yayınevi; 2003:309-20
  3. Fuso L, Incalzi RA, Pistelli R et al. Predicting mortality of patients hospitalized for acutely exacerbated chronic obstructive pulmonary disease. Am J Med 1995;98:272-7
  4. Antonelli Incalzi R, Fuso L, De Rosa M et al. Co-morbidity contributes to predict mortality of patients with chronic obstructive pulmonary disease. Eur Respir J 1997;10:2794-800
  5. Katus HA, Remppis A, Neumann FJ et al. Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation 1991;83:902-12
  6. Apple FS, Rogers MA, Casal DC et al. Creatine kinase-MB isoenzyme adaptations in stressed human skeletal muscle of marathon runners. J Appl Physiol 1985;59:149-53
  7. Meyer T, Binder L, Hruska N et al. Cardiac troponin I elevation in acute pulmonary embolism is associated with right ventricular dysfunction. J Am Coll Cardiol 2000;36:1632-6
  8. Spies C, Haude V, Fitzner R et al. Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 1998;113:1055-63
  9. Weinberg I, Cukierman T, Chajek-Shaul T. Troponin T elevation in lobar lung disease. Postgrad Med J 2002;78:244-5
  10. Baillard C, Boussarsar M, Fosse JP et al. Cardiac troponin I in patients with severe exacerbation of chronic obstructive pulmonary disease. Intensive Care Med 2003;29:584-9
  11. American Thoracic Society Medical Section of the American Lung Association. Standarts for the diagnosis and care of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1995;152:77-120
  12. Global Initiative for Chronic Obstructive Lung Disease (NIH), April 2001
  13. Standardized lung function testing. European Community for Steel and Coal, Official Statement of the European Respiratory Society. Eur Respir J 1993;6(Suppl):1-100
  14. Harvey MG, Hancox RJ. Elevation of cardiac troponins in exacerbation of chronic obstructive pulmonary disease. Emerg Med Australas 2004;16:212-5
  15. Rottbauer W, Greten T, Muller-Bardorff M et al. Troponin T: a diagnostic marker for myocardial infarction and minor cardiac cell damage. Eur Heart J 1996;17:3-8
  16. Khan IA, Tun A, Wattanasauwan N et al. Elevation of serum cardiac troponin I in noncardia