Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2011 / Cilt: 45 - Sayı: 3

An important side effect of lamotrigin use: combined of Stevens johnson syndrome and toxic epidermal necrolysis

Lamotrigin kullanımına bağlı önemli bir yan etki: Stevens-johnson sendromu ve toksik epidermal nekrolizis birlikteliği

Pages
98–101
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this study, we report a patient diagnosed generalized seizures, and who had received Lamotrigine but developed generalized skin rash at the second week of treatment and the drug was stopped.

📌 3 Key Takeaways

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Objective & Hypothesis:Stevens-Johnson syndrome is a rare, potentially life-threatening syndrome that occurs two months after exposure to anticonvulsants drugs such as phenobarbital, phenytoin, carbamazepine and lamotrigine.
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Key Findings & Data:The use of the offending drug must be terminates immediately to prevent potentially fatal outcomes.
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Conclusion & Impact:In this study, we report a patient diagnosed generalized seizures, and who had received Lamotrigine but developed generalized skin rash at the second week of treatment and the drug was stopped.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Stevens-Johnson syndrome is a rare, potentially life-threatening syndrome that occurs two months after exposure to anticonvulsants drugs such as phenobarbital, phenytoin, carbamazepine and lamotrigine. The use of the offending drug must be terminates immediately to prevent potentially fatal outcomes. In this study, we report a patient diagnosed generalized seizures, and who had received Lamotrigine but developed generalized skin rash at the second week of treatment and the drug was stopped.

Özet

Antikonvulsanlara bağlı Stevens- Johnson sendromu fenobarbital, fenitoin, karbamazepin ve lamotrigin gibi antiepileptik ilaçların neden olduğu, genellikle tedavinin başlangıcından sonraki ilk iki ay içinde ortaya çıkan, ağır cilt reaksiyonları ile karakterize nadir ve yaşamı tehdit edici bir klinik tablodur. Mortalite riski nedeniyle Stevens Johnson sendromuna neden olabilecek ilaçlar en kısa süre içinde kesilmeli ve farklı gruptan ilaçlarla tedaviye devam edilmedilir. Bu çalışmada generalize epilepsi tanısı nedeniyle Lamotrigin tedavisi başlanan ve tedavinin ikinci haftasında vücutta ortaya çıkan yaygın deri döküntüleri nedeniyle ilaç tedavisi kesilen bir olgu sunulmuştur.

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Cite This Article

KAFADAR, İ., DİLER, B., DALGIÇ, N. K., HAŞİM, Ö. (2011). An important side effect of lamotrigin use: combined of Stevens johnson syndrome and toxic epidermal necrolysis. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 45 - Sayı: 3, 98–101. https://ajindex.com/articles/364214

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References (6)

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