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Journals / The Turkish Journal of Ear Nose and Throat / 2020 / Cilt: 30 - Sayı: 4

The effect of vitamin D levels on prognosis of patients with facial paralysis

Ayşe Enise GÖKER
Semih KARAKETİR
Maide Hacer ALAGÖZ
Ayça BAŞKADEM YILMAZER
Hüseyin SARI
Hasan Sami BİRCAN
Nilgün BAŞARAN
Pages
118–122
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

A significant decrease in vitamin D levels was observed in the patients with HBS Grade ≥4, compared to Grade 3 and Grade 2 groups p=0.002 and p

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: This study aims to investigate the serum 25-hydroxyvitamin D3 [25 OH D3] levels of patients with Bell’s palsy BP , and to evaluate their role in prognosis and their impact on the disease etiology.
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Key Findings & Data:Patients and Methods: A total of 49 patients 30 males, 19 females; mean age: 42.2±13.6 years; range, 19 to 67 years who were diagnosed with BP and treated at our clinic between October 2019 and April 2020 were included.
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Conclusion & Impact:A significant decrease in vitamin D levels was observed in the patients with HBS Grade ≥4, compared to Grade 3 and Grade 2 groups p=0.002 and p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Bell’s palsy · facial paralysis · vitamin D deficiency

Abstract

Objectives: This study aims to investigate the serum 25-hydroxyvitamin D3 [25 OH D3] levels of patients with Bell’s palsy BP , and to evaluate their role in prognosis and their impact on the disease etiology. Patients and Methods: A total of 49 patients 30 males, 19 females; mean age: 42.2±13.6 years; range, 19 to 67 years who were diagnosed with BP and treated at our clinic between October 2019 and April 2020 were included. Blood samples were collected within 24 h after the onset of BP symptoms, and a standard oral pharmacological treatment was administered with prednisolone 1 mg/kg for 10 days and acyclovir 700 mg/day for six days. All patients were graded according to the House-Brackmann scale HBS . The patients were divided into three groups as Grade 2, Grade 3, Grade ≥4. The patients with BP were further divided into two groups as healed n=36 and not-healed ones n=13 . The vitamin D levels of the groups were compared. Results: Eleven 22% patients were in the Grade 2 group, 21 43% patients were in the Grade 3 group, and 17 35% patients were in the Grade ≥4 group. A significant decrease in vitamin D levels was observed in the patients with HBS Grade ≥4, compared to Grade 3 and Grade 2 groups p=0.002 and p

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Cite This Article

GÖKER, A. E., KARAKETİR, S., ALAGÖZ, M. H., YILMAZER, A. B., SARI, H., BİRCAN, H. S., BAŞARAN, N. (2020). The effect of vitamin D levels on prognosis of patients with facial paralysis. The Turkish Journal of Ear Nose and Throat, Cilt: 30 - Sayı: 4, 118–122. https://ajindex.com/articles/362530

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References (12)

  1. Adour KK. Current concepts in neurology: Diagnosis and management of facial paralysis. N Engl J Med 1982;307:348-51. Fisch U. Management of intratemporal facial nerve injuries. J Laryngol Otol 1980;94:129-34.
  2. Murthy JM, Saxena AB. Bell's palsy: Treatment guidelines. Ann Indian Acad Neurol 2011;14(Suppl 1):S70-2. Baugh RF, Basura GJ, Ishii LE, Schwartz SR, Drumheller CM, Burkholder R, et al. Clinical practice guideline: Bell’s palsy. Otolaryngol Head Neck Surg 2013;149(3 Suppl):S1-27. Wrzosek M, Łukaszkiewicz J, Wrzosek M, Jakubczyk A, Matsumoto H, Piątkiewicz P, et al. Vitamin D and the central nervous system. Pharmacol Rep 2013;65:271-8. Holick MF. Vitamin D for health and in chronic kidney disease. Semin Dial 2005;18:266-75. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81.
  3. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 2005;29:21-30.
  4. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev 1998;78:1193-231.
  5. Vanherwegen AS, Gysemans C, Mathieu C. Regulation of immune function by vitamin D and its use in diseases of immunity. Endocrinol Metab Clin North Am 2017;46:1061-94.
  6. Laird E, McNulty H, Ward M, Hoey L, McSorley E, Wallace JM, et al. Vitamin D deficiency is associated with inflammation in older Irish adults. J Clin Endocrinol Metab 2014;99:1807-15.
  7. Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annu Rev Pharmacol Toxicol 2001;41:421-42.
  8. Cornet A, Baudet C, Neveu I, Baron-Van Evercooren A, Brachet P, Naveilhan P. 1,25-Dihydroxyvitamin D3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. J Neurosci Res 1998;53:742-6.
  9. Baas D, Prüfer K, Ittel ME, Kuchler-Bopp S, Labourdette G, Sarliève LL, et al. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25-dihydroxyvitamin D(3). Glia 2000;31:59-68. Holick MF. Vitamin D status: Measurement, interpretation, and clinical application. Ann Epidemiol 2009;19:73-8.
  10. Alberton DL, Zed PJ. Bell’s palsy: A review of treatment using antiviral agents. Ann Pharmacother 2006;40:1838-42.
  11. Tiemstra JD, Khatkhate N. Bell's palsy: Diagnosis and management. Am Fam Physician 2007;76:997-1002.
  12. Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: Lessons learned from genome-wide analysis. Front Physiol 2014;5:151. Veldman CM, Cantorna MT, De