Journals / Tıp Araştırmaları Dergisi / 2004 / Cilt: 2 - Sayı: 1

The role of procalcitonin, neopterin and C-reactive protein for diagnosis and monitoring in infectious diseases of childhood

Çocukluk çağı enfeksiyonlarının tanı ve takibinde prokalsitonin, neopterin ve C-reaktif proteinin rolü

Pages
11–17
DOI
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Conclusion: We conclude that CRP now still maintains its value as a practical and valuable determinant in diagnosis of bacterial infections and PCT is more sensitive test in evaluating the response to therapy in such diseases and in some rare clinical situations.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To study the levels of procalcitonin, C-reactive protein and neopterin in infection diseases seen in pediatrics department and to evaluate the discriminative role of procalcitonin (PCT), C-reactive protein (CRP) and neopterin in differentiating bacterial infection from viral infection.
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Key Findings & Data:Methods: Absolute neutrophyl count (ANC), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), CRP, PCT and neopterin were measured in 44 children admitted to pediatrics clinic for an infection disease.
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Conclusion & Impact:Conclusion: We conclude that CRP now still maintains its value as a practical and valuable determinant in diagnosis of bacterial infections and PCT is more sensitive test in evaluating the response to therapy in such diseases and in some rare clinical situations.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kalsitonin · Çocuk · Tanı teknik ve işlemleri

Abstract

Objective: To study the levels of procalcitonin, C-reactive protein and neopterin in infection diseases seen in pediatrics department and to evaluate the discriminative role of procalcitonin (PCT), C-reactive protein (CRP) and neopterin in differentiating bacterial infection from viral infection. Methods: Absolute neutrophyl count (ANC), white blood cell count (WBC), erythrocyte sedimentation rate (ESR), CRP, PCT and neopterin were measured in 44 children admitted to pediatrics clinic for an infection disease. Results: We found the sensitivity of ANC, leucocytosis, ESR, CRP and PCT in differentiating bacterial and viral infections as 73%, 62%, 88%, 96% and 73%, and the specificity as 94%, 72%, 61%, 83% and 94% respectively. Conclusion: We conclude that CRP now still maintains its value as a practical and valuable determinant in diagnosis of bacterial infections and PCT is more sensitive test in evaluating the response to therapy in such diseases and in some rare clinical situations.

Özet

Amaç: Çocukluk çağı enfeksiyonlarında viral/bakteriyel etiyolojiyi tanımada prokalsitonin, C-reaktif protein ve neopterinin rolünün belirlenmesi amaçlandı. Gereç ve Yöntem: Enfeksiyon şüphesi ile hastaneye yatırılan bir ay ile 14 yaş arasındaki 44 çocuk ile aynı yaş ve cinsiyette sağlıklı 35 çocuktan mutlak nötrofil sayısı (MNS), beyaz küre sayısı (BK), eritrosit sedimantasyon hızı (ESH), C-reaktif protein (CRP), prokalsitonin (PCT) ve neopterin ölçümleri yapıldı. Bulgular: Bakteriyel ve viral enfeksiyonların ayırımında MNS, lökositoz, ESH, CRP ve PCT'nin duyarlıkları sırasıyla % 73, % 62, % 88, % 96 ve % 73, özgüllükleri ise sırasıyla % 94, % 72, % 61, % 83 ve % 94 olarak bulundu. Neopterin duyarlı ve özgül değildi. Sonuç: CRP'nin bakteriyel enfeksiyonların tanısında halen pratik ve önemli bir belirteç olarak değerini koruduğu; bu hastalıkların tedavi yanıtlarını değerlendirmede ve bazı nadir klinik durumlarda ise PCT ölçümünün daha duyarlı bir test olduğu sonucuna varıldı.

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Cite This Article

AYATA, A., GENÇ, H., SÜTÇÜ, R. (2004). The role of procalcitonin, neopterin and C-reactive protein for diagnosis and monitoring in infectious diseases of childhood. Tıp Araştırmaları Dergisi, Cilt: 2 - Sayı: 1, 11–17. https://ajindex.com/articles/361982

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