In diagnosis of neonatal sepsis make a comparison il-6, CRP and procalcitonin

Key Findings & Data:Methods: The study was included totally 36 newborn (16 of 32 newborn with sepsis as patient group, remaining 16 newborn without infection but hospitalized because of other causes as control group).

💡

Conclusion & Impact:Coclusion: In conclusion, we emphasized that PCT was found to be statistically unimportant in diagnosis of early neonatal sepsis.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Sepsis · İnterlökin-6 · Tanı

Abstract

Aim: The aim of this study was to determine the importance of PCT as a diagnostic marker in neonatal sepsis. Methods: The study was included totally 36 newborn (16 of 32 newborn with sepsis as patient group, remaining 16 newborn without infection but hospitalized because of other causes as control group). In patient group, 8 of them was diagnosed as early neonatal sepsis, remaining 8 patient was diagnosed as late neonatal sepsis. Blood samples for IL-6, CRP, PCT was taken on first, second, third and fifth day of admission. Result: Although both IL-6 and CRP levels were found to be statistically significant in diagnosis of early neonatal sepsis, but only IL-6 level was found to be statistically significant in discrimination of early and late neonatal sepsis's diagnosis. The differences of IL-6 and CRP levels were determined as statistically significant on 0-5 days and 1-5 days respectively. Coclusion: In conclusion, we emphasized that PCT was found to be statistically unimportant in diagnosis of early neonatal sepsis.

Özet

Amaç: Yenidoğan sepsisinde erken tanı prokalsitoninin bir enfeksiyon belirteci olarak kullanılıp kullanılmayacağını belirlemek. Yöntem: Bu çalışmaya sepsis tanısıyla yenidoğan ünitesinde yatan 16 yenidoğan ve sepsisi olmayan 16 yenidoğan alındı. Sepsisi olan hastaların 8 tanesinde erken geri kalanlarında da geç neonatal sepsis vardı. Hastalardan ve kontrol gubundakii yenidoğanlardan başvuruda, 1., 2., 3. ve 5. günlerde IL-6, CRP ve PCT alınarak karşılaştırıldı. Bulgular: Erken neonatal sepsis tanısında IL-6 ve CRP istatistiksel olarak anlamlı bulunurken; erken ve geç sepsis ayrımında sadece IL-6 anlamlı bulunmuştur. IL-6 düzeylerinin sepsis grubunda 0- 5. Günlerde; CRP'nin ise, 1-5. günlerde istatiksel olarak anlamlı farklılık olduğu tespit edildi. Sonuç: Yenidoğan sepsisin erken tanisinda serum PCT duzeyleri kullanışlı bir belirteç degildir.

Keywords

Sepsis İnterlökin-6 Tanı Süt çocuğu yenidoğan Interleukin-6 Diagnosis Infant Newborn

🔖

Cite This Article

YILMAZ, C., DİLMEN, U., Kaya, İ. S., UYSAL, F., ÖNAL, E. (2009). In diagnosis of neonatal sepsis make a comparison il-6, CRP and procalcitonin. Tıp Araştırmaları Dergisi, Cilt: 7 - Sayı: 3, 151–156. https://ajindex.com/articles/361971

📄 Full Text PDF Viewer

Open in New Tab ↗

↗New Tab

📄

PDF görüntüleyici hazırlanıyor...

References (14)

Poll T, Devender S. Bacterial sepsis and septic shock, cytokines and anticytokines in the pathogenesis of sepsis. Infec Dis Clin North Am 1999; 13: 413-26
Franz A, Kron M, Pohlandt F. Comparison of procalcitonin with interleukin 8, C-reactive protein and differential white blood cell count for the early diagnosis of bacterial infections in newborn infants. JPediatr Infec Dis 1999; 18: 666-71
Gerdes J. Clinicopathologic Approach to Diagnosis of Neonatal Sepsis. Clinics in Perinatology, 1991; 18: 361-79 4. Özalp İ, Yurdakök M, Coşkun T: Neonatal Sepsiste Antibiyotik Tedavisi: Pediatride Gelişmeler. 1.baskı. Özalp İ,Yurdakök M, Coşkun T, Sinem ofset, Ankara 1999: 270- 90
Mehr S, Doyle L. Cytokines as markers of bacterial sepsis in newborn infants. J Pediatr Infec Dis 2000; 19: 870-7
Grzywing W, Stempniowicz K, Bodzek K.Evaluating the usefulness of qualitative analysis of latex C-reactive protein for diagnosis neonatal sepsis. Gynecolcol 1992; 63: 447-90
Krediet T, Gerard L, Fleer A. The predictive value of CRP and I/T-ratio in neonatal infection. J Perinat Med 1992; 20: 479-85
Nga PC, Cheng SH, Chui KM. Diagnosis of late onset neonatal sepsis with cytokines, adhesion molecule, and C-reactive protein in preterm very low-birth weight infants, Arch Dis Child 1997; 77: 221-27 9. Doellner H, Arntzen K, Haerreid P. Interleukin–6 concentrations in neonates evaluated for sepsis.J Pediatr 1998; 132: 195- 99
Önal E,Uysal F,Dilmen U,Adam B. İnterleukin –6 contrations in neonatal sepsis. Lancet1999; 353:239-40
Sakha K, Husseini MB, Seyyedsadri N.The role of the procalcitonin in diagnosis of neonatal sepsis and correlation between procalcitonin and C-reactive protein in these patients. Pak J Biol Sci. 2008 Jul 15;11(14):1785-90
Santuz P, Soffiati M, Dorizzi RM, Benedetti M, Zaglia F, Biban P. Procalcitonin for the diagnosis of early-onset neonatal sepsis: a multilevel probabilistic approach. Clin Biochem. 2008 Oct;41(14-15):1150-5
Mussap M, Degrandi R, Cataldi L, Fanos V, Plebani M.Biochemical markers for the early assessment of neonatal sepsis: the role of procalcitonin. J Chemother. 2007;19 Suppl 2:35-8
Mannoet G, Labaune JM, Isaac C. Procalcitonin and Creaktive protein levels in neonatal infections. Acta Pediatr 1997;86: 209-12
Gendrel D, Assicot M, Raymond J. Precalcitonin as a marker for the early diagnosis of neonatal infection. J Pediatr 1996; 128: 570-3
Assicot M, Gendrel D, Carsın H.High