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Journals / Tıp Araştırmaları Dergisi / 2015 / Cilt: 13 - Sayı: 1

Mechanisms of Cerebral Ischemia

Serebral İskemi Oluşum Mekanizmaları

Gönül BAMBAL
Gökhan KALAYCI
Fatih EKİCİ
Pages
36–43
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Identification of these injury mediators and pathways will allow the development of potentially more effective therapeutic and neuroprotective strategies in cerebral ischemia

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cerebral Ischemia is defined as a reduction in cerebral blood flow sufficient to alter cerebral function and activate complex several signalling cascades, as well as excitotoxic glutamatergic signalling, ionic imbalance, free-radical reactions, and genetic, inflammation and apoptosis.
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Key Findings & Data:Cerebral ischemia can cause neuronal death via different signaling cascades.
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Conclusion & Impact:Identification of these injury mediators and pathways will allow the development of potentially more effective therapeutic and neuroprotective strategies in cerebral ischemia
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Cerebral Ischemia is defined as a reduction in cerebral blood flow sufficient to alter cerebral function and activate complex several signalling cascades, as well as excitotoxic glutamatergic signalling, ionic imbalance, free-radical reactions, and genetic, inflammation and apoptosis. Cerebral ischemia can cause neuronal death via different signaling cascades. Identification of these injury mediators and pathways will allow the development of potentially more effective therapeutic and neuroprotective strategies in cerebral ischemia

Özet

Serebral iskemi (Sİ), beyin fonksiyonunu değiştirmek için yeterli düzeyde olan serebral kan akımında (SKA) meydana gelen bir azalma olarak tanımlanmaktadır. Sİ ile inflamasyon, apoptozis, genetik, serbest radikal reaksiyonları, iyonik dengesizlik, eksitotoksik glutamaterjik sinyaller gibi birçok karmaşık sinyal kaskadlarını aktive olmakta ve sonuçta nöronal ölüme neden olmaktadır. Bu hasarın aracı moleküllerinin ve yolaklarının tanımlanması, Sİ'de potansiyel olarak daha etkili teropatik ve nöroprotektif stratejilerin geliştirilmesine olanak sağlayacaktır

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Cite This Article

BAMBAL, G., KALAYCI, G., EKİCİ, F. (2015). Mechanisms of Cerebral Ischemia. Tıp Araştırmaları Dergisi, Cilt: 13 - Sayı: 1, 36–43. https://ajindex.com/articles/361942

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