Journals / Tıp Araştırmaları Dergisi / 2010 / Cilt: 8 - Sayı: 1

Systemic lupus erythematosus and multiple miyeloma: A case report

Multipl miyeloma ve sistemik lupus eritematozus: Bir olgu sunumu

Pages
47–50
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result, when monoclonal gammopati is detected in patients with SLE, MM should be considered.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Multiple myeloma (MM) associated with systemic lupus erythematosus (SLE) has been rarely reported. 20-year-old female was admitted to our clinic with complaints; hair loss, arthralgia, recurrent back pain and discoloration of the fingers and toes when exposed to cold.
📊
Key Findings & Data:Laboratory findings were as follows; sedimentation rate: 96 mm / h, anti nuclear antibody positive (granular 1:1000) and C3 and C4 was low.
💡
Conclusion & Impact:As a result, when monoclonal gammopati is detected in patients with SLE, MM should be considered.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Multiple myeloma (MM) associated with systemic lupus erythematosus (SLE) has been rarely reported. 20-year-old female was admitted to our clinic with complaints; hair loss, arthralgia, recurrent back pain and discoloration of the fingers and toes when exposed to cold. Laboratory findings were as follows; sedimentation rate: 96 mm / h, anti nuclear antibody positive (granular 1:1000) and C3 and C4 was low. In the spinal MR, the mass lesions pressuring on the spinal cord were found. In the abdominal BT, 5x2.5 cm mass lesion was detected in the below spleen. The plasma cell infiltration was found in the abdominal mass and bone marrow biopsy examination. With these findings, SLE, MM and ekstramedüler plazmasitom were diagnosed. As a result, when monoclonal gammopati is detected in patients with SLE, MM should be considered.

Özet

Multipl miyeloma (MM) ve sistemik lupus eritematozus (SLE) birlikteliği çok nadir olarak bildirilmiştir. 20 yaşındaki kadın saç dökülmesi, soğukta el ve ayaklarda morarma, tekrarlayan eklem ve bel ağrısı şikayetleriyle kliniğimize başvurdu. Tetkiklerinde sedimantasyon: 96 mm/saat, Anti nükleer antikor 1:1000 granüler pozitif, C3 ve C4 düşüktü. Hastanın vertebra MR tetkikinde spinal korda bası yapan kitleler ve batın tomografisinde dalak alt pol komşuluğunda 5x2.5 cm çapında kitle lezyon saptandı. Batındaki kitle ve kemik iliği biyopsisinde malin plazma hücre infiltrasyonu tespit edildi. Bu bulgularla hastaya SLE, MM ve ekstramedüler plazmasitom tanısı kondu. Sonuç olarak SLE’li hastalarda monoklonal gammopati tespit edildiğinde MM şüphesiyle etraflıca araştırılması gerektiğini düşünmekteyiz.

🔖

Cite This Article

DEMİR, C., METE, R., DÜLGER, C. (2010). Systemic lupus erythematosus and multiple miyeloma: A case report. Tıp Araştırmaları Dergisi, Cilt: 8 - Sayı: 1, 47–50. https://ajindex.com/articles/361913

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Black KA, Zilko PJ, Dawkins RL, Armstrong BK, Mastaglia GL. Cancer in connective tissue disease. Arthritis Rheum 1982; 25:1130-3
  2. Menon S, Snaith ML, Isenberg DA. The association of malignancy with SLE: an analysis of 150 patients under long-term review. Lupus 1993; 2:177-81
  3. Munzert G, Frickhofen N, Bauditz J, Schreiber S, Herrmann F. Concomitant manifestation of systemic lupus erythematosus and low-grade non-Hodgkin's lymphoma. Leukemia 1997; 11:1324-8
  4. Agudelo CA, Schumacher HR, Glick JH, Molina J. Non-Hodgkin's lymphoma in systemic lupus erythematosus: report of 4 cases with ultrastructural studies in 2. J Rheumatol 1981; 8:69-78
  5. Green JA, Dawson AA, Walker W. Systemic lupus erythematosus and lymphoma. Lancet 1978; 2:753-6
  6. Lopez Dupla M, Khamashta M, Pintado Garcia V, Lavilla Uriol P, Valencia Ortega E, Gil Aguado A. Malignancy in systemic lupus erythematosus: a report of five cases in a series of 96 patients. Lupus 1993; 2:377-80
  7. Lugassy G, Lishner M, Polliack A. Systemic lupus erythematosus and chronic lymphocytic leukemia: rare coexistence in three patients, with comments on pathogenesis. Leuk Lymphoma 1992; 8:243-5
  8. Youinou P, Le Corre R, Dueymes M. Autoimmune diseases and monoclonal gammopathies. Clin Exp Rheumatol 1996; 14:55-8
  9. Afeltra A, Amoroso A, Garzia P, Addessi MA, Pulsoni A, and Bonomo L. Systemic Lupus Erythematosus and Multiple Myeloma: A Rare Association. Semin Arthritis Rheum 1997; 26:845-49
  10. Bila J, Suvajdzic N, Elezovic I, Colovic M, Boskovic D. Systemic lupus Erythematosus and IgA multiple myeloma: a rare association?. Med Oncol. 2007; 24:445-8
  11. Maamar M, Tazi Mezalek Z, Harmouche H, Adnaoui M, Aouni M, Maaouni A. Systemic lupus erythematosus and multiple myeloma: an uncommon association. Two cases and literature review. Clin Exp Rheumatol. 2008; 26:667-70
  12. Okoli K, Irani F, Horvath W. Multiple myeloma and systemic lupus erythematosus in a young woman. J Clin Rheumatol. 2009; 15:292- 4
  13. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25:1271-7
  14. Umemura T, Hirai S, Ohashi M. Systemic lupus erythematosus with multiple myeloma. Nippon Hifuka Gakkai Zasshi 1988; 98:1495-1503
  15. Solary E, Caillot D, Guy H, Olsson NO, Tanter Y, Chalopin JM. Systemic lupus erythematosus occurring in a patient with multiple myeloma. Arthritis Rheum 1986; 29:933-4
  16. Lang B, Röther E, Hauke G, Peter HH. Systemic lu