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Journals / Tıp Araştırmaları Dergisi / 2010 / Cilt: 8 - Sayı: 1

Evaluation of clinical and laboratory characteristic in patients with primary sjogren’s syndrome

Primer Sjögren sendromu olan 25 hastanın klinik ve laboratuar bulgularının değerlendirilmesi

AYŞE ÇEFLE
AYTEN YAZICI
Tuğba TURGUT
Pages
22–26
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In addition xerostomia and keratoconjonctivitis sicca, which are the spesific signs of pSS, non-spesific findings such as weakness arthralgia and generalized body pain are also frequent in this disorder.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Evaluation of the clinical and laboratory characteristics of patients with primary Sjogren’s syndrome (pSS).
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Key Findings & Data:Methods: Clinical records of 25 patients were evaluated rerospectively; all the patients had been diagnosed with pSS according to European-American classification.
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Conclusion & Impact:Conclusion: In addition xerostomia and keratoconjonctivitis sicca, which are the spesific signs of pSS, non-spesific findings such as weakness arthralgia and generalized body pain are also frequent in this disorder.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Evaluation of the clinical and laboratory characteristics of patients with primary Sjogren’s syndrome (pSS). Methods: Clinical records of 25 patients were evaluated rerospectively; all the patients had been diagnosed with pSS according to European-American classification. Results: All the patients were female with a mean age of 47.16 ± 13.58 years. All of them had keratoconjonctivitis sicca and xerostomia. The most frequent findings were arthralgia/arthritis, weakness, generalized body pain, recurring attacks of parotitis and weight loss. Rheumatoid factor (RF) and anti-nuclear antibodies (ANA) were positive in 80% and 92% of the patients, respectively. Anti-Ro and anti-La antibodies were detected in 64% and 56% of the patients, respectively. One patient was dignosed with autoimmune hepatitis, two with primary biliary cirrhosis and another one with autoimmune thyroiditis (Hashimoto thyroiditis). Conclusion: In addition xerostomia and keratoconjonctivitis sicca, which are the spesific signs of pSS, non-spesific findings such as weakness arthralgia and generalized body pain are also frequent in this disorder.

Özet

Amaç: Primer Sjögren sendromu (pSS) tanısıyla takip edilen hastaların klinik ve laboratuar özelliklerini ortaya koymayı amaçladık. Gereç ve Yöntem: Romatoloji Polikliniği’ne başvuran ve Avrupa-Amerika sınıflandırma kriterlerine göre pSS tanısı konulan 25 hastanın dosyaları retrospektif olarak değerlendirildi. Bulgular: Hastaların tamamı kadın olup ortalama yaş 47.16 ± 13.58 idi. Hastaların tamamında ağız ve göz kuruluğu vardı. Artralji/artrit, halsizlik, yaygın vücut ağrısı, tekrarlayan parotit atakları ve kilo kaybı en sık görülen bulgulardı. Romatoid faktör (RF) % 80 ve anti-nükleer antikorlar (ANA) % 92 hastada pozitif bulundu. Hastaların % 64’ünde anti-Ro, %56’sında anti-La antikorları pozitif idi. Bir hastada otoimmün hepatit, 2’sinde primer biliyer siroz ve 1 hastada da otoimmün tiroidit (Hashimoto tiroditi) tespit edildi. Sonuç: pSS’de ağız-göz kuruluğu gibi spesifik bulgular yanında halsizlik, yaygın vücut ağrısı, artralji gibi nonspesifik bulgular da sık görülmektedir. Bu durum tanıda güçlüklere sebep olabilmektedir.

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Cite This Article

ÇEFLE, A., YAZICI, A., TURGUT, T. (2010). Evaluation of clinical and laboratory characteristic in patients with primary sjogren’s syndrome. Tıp Araştırmaları Dergisi, Cilt: 8 - Sayı: 1, 22–26. https://ajindex.com/articles/361855

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