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Journals / Tıp Araştırmaları Dergisi / 2013 / Cilt: 11 - Sayı: 3

Association Between Fasting Plasma Glucose and Routine Coagulation Tests

Rutin Koagiilasyon Testleri ve. Açlık Plazma Glukozu Arasındaki Ilişki

ALEV KURAL
Hatice SEVAL
Aysun TOKER
Rana TURKAL
Macit KOLDA
Pages
99–102
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Shortened APTT and increased fibrinogen levels in both diabetic group and IFG group could be a useful marker for evaluation of hemostatic state.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The main goal of this study was to determine relationship between activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen levels and fasting plasma glucose levels (FPG).
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Key Findings & Data:Methods: In 5602 patients APTT, PT, fibrinogen and FPG levels were measured by routine methods.
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Conclusion & Impact:Conclusion: Shortened APTT and increased fibrinogen levels in both diabetic group and IFG group could be a useful marker for evaluation of hemostatic state.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The main goal of this study was to determine relationship between activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen levels and fasting plasma glucose levels (FPG). Methods: In 5602 patients APTT, PT, fibrinogen and FPG levels were measured by routine methods. Patients were divided into three groups according to their FPG levels (euglycemic, impaired fasting glucose group (IFG) and diabetic group). Results: We found significantly shorter APTT values and increased fibrinogen levels in both diabetic group and IFG group when compared with the euglycemic group. Conclusion: Shortened APTT and increased fibrinogen levels in both diabetic group and IFG group could be a useful marker for evaluation of hemostatic state.

Özet

Amaç: Bu çalı manın temel amacı aktive parsiyel tromboplastin zamanı (APTZ), protrombin zamanı (PZ), fibrinojen seviyeleri ve açlık plazma glukoz (APG) seviyelerinin arasındaki ili kiyi belirlemektir. Gereç ve Yöntem: 5602 hastada APTZ, PZ, fibrinojen ve APG seviyeleri rutin metodlar ile ölçülmü tür. Hastalar, APG seviyelerine göre üç gruba ayrılmı tır (öglisemik, bozulmu açlık glukozu (BAG) ve diabetik grup). Sonuçlar: Çalı mamızda, öglisemik gruba kıyasla hem diabetic hem de BAG gruplarında önemli kısalmı APTZ ve önemli artmı fibrinojen seviyeleri bulduk. Sonuç: Kısalmı APTZ ve artmı fibrinojen seviyeleri hem diabetik hem de BAG grubunda hemostatik durumun de erlendirilmesinde yararlı bir belirteç olarak kullanılabilir.

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Cite This Article

KURAL, A., SEVAL, H., TOKER, A., TURKAL, R., KOLDA, M. (2013). Association Between Fasting Plasma Glucose and Routine Coagulation Tests. Tıp Araştırmaları Dergisi, Cilt: 11 - Sayı: 3, 99–102. https://ajindex.com/articles/361846

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References (15)

  1. Langdell RD, Wagner RH, Brinkhous KM. Effect of antihemophilic factor on one-stage clotting tests: a presumptive test for hemophilia and a simple one-stage antihemophilic factor assay procedure. J Lab Clin Med 1953; 41:637-647
  2. Proctor RR, Rapaport SI. The partial thromboplastin time with kaolin: a simple screening test for first stage plasma clotting factor deficiencies. Am J Clin Path 1961; 36:212-219
  3. Ten Boekel E, Böck M, Vrielink GJ,et al. Detection of shortened activated partial thromboplastin times: an evaluation of different commercial reagents. Thromb Res 2007; 121:361- 367
  4. Korte W, Clarke S, Lefkowitz JB. Short activated partial thromboplastin times are related to increased thrombin generation and an increased risk for thromboembolism. Am J Clin Pathol 2000; 113:123-127
  5. Tripodi A, Chantarangkul V, Martinelli I, et al. A shortened APTT is associated with the risk of venous thromboembolism.Blood2004; 104:3631-4
  6. Hron G, Eichinger S, Weltermann A, et al. Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time. J Thromb Haemost 2006; 4:752-6
  7. Clement S, Braithwaite SS, Magee MF, et al. American Diabetes Association Diabetes in Hospitals Writing Committee Management of diabetes and hyperglycemia in hospitals. Diabetes Care 2004; 27:553-91
  8. Ceriello A. Coagulation activation in diabetes mellitus: the role of hyperglycaemia and therapeutic prospects. Diabetologia 1993; 36:1119-25
  9. Grant PJ. Diabetes mellitus as a prothrombotic condition. J Intern Med 2007; 262:157-72
  10. Reddy NM, Hall SW, MacKintosh FR. Partial thromboplastin time: prediction of adverse events and poor prognosis by low abnormal values. Arch Intern Med 1999; 159:2706-2710
  11. Zhao Y, Zhang J, Zhang J, Wu J. Diabetes mellitus is associated with shortened activated partial thromboplastin time and increased fibrinogen values. PLoS One 2011; 28;6(1):e16470
  12. Lippi G, Franchini M, Targher G, et al. Epidemiological association between fasting plasma glucose and shortened APTT. Clin Biochem 2009; 42:118-120
  13. Lippi G, Salvagno GL, Montagnana M, Guidi GC. Short-term venous stasis influences routine coagulation testing. Blood Coagul Fibrinolysis 2005; 16:453-458
  14. Lippi G, Favaloro EJ. Activated partial thromboplastin time: new tricks for an old dogma. Semin Thromb Hemost 2008; 34:604-611
  15. Madi AM, Greci LS, Nawaz H, et al. The activated partial thromboplastin time in early diagnosis of myocardial infarction. Blood C