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Journals / Tıp Araştırmaları Dergisi / 2011 / Cilt: 9 - Sayı: 1

Determination of the incidance of micronucleus and binucleotids in the buccal mucosa of printing industry workers

Matbaa sanayinde çalışan işçilerin bukkal mukoza hücrelerinde mikronükleus ve binükleotid sıklığının belirlenmesi

Ayşin YILDIRIM
M. Selman YILDIRIM
Pages
25–28
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These findings in terms of health workers may be eligible to be considered.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: To determine whether exposure to chemical agents cause mutagenic effects in printing industry workers.
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Key Findings & Data:Methods: 30 printing industry workers and 30 control subjects were recruited for the study .
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Conclusion & Impact:These findings in terms of health workers may be eligible to be considered.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: To determine whether exposure to chemical agents cause mutagenic effects in printing industry workers. Methods: 30 printing industry workers and 30 control subjects were recruited for the study . To detect mutagenic effects, micronuclei and binucleotid in buccal mucosal cells were tallied. 1500 cells were counted for the average patient. Results: The MN rates for all patients and control groups were compared, the percentage of MN was 0:29 ± 0.16 in case group and 0.13 ± 0.61 in control group, respectively. Similarly Binükleotid (BN) cells were compared between patient and control groups, being 0.30 ± 0.18 and 0.12± 0.05, respectively. In both micronuclei and binukleotid, statistical difference was present between cases and controls. Conclusion: The printing industry workers, according to the normal population rate of increase in oral mucosal cells was observed in the MN and BN. These findings in terms of health workers may be eligible to be considered.

Özet

Amaç: Matbaa sanayinde çalışan işçilerin maruz kaldıkları kimyasal ajanların mutajenik etkilerininin olup olmadığını belirlemektir. Metod: 30 matbaa sanayi çalışanı ve 30 kontrol grubu araştırmaya dahil edildi.. Mutajenik etkiyi tespit etmek için buccal mukoza hücrelerinde mikronukleus ve binukleotid sayımı yapıldı. Ortalama her hasta için 1500 hücre sayıldı. Bulgular: MN oranları için tüm vaka ve kontrol grubu karşılaştırıldığında; vaka grubunun MN yüzdesi 0.29 ± 0,16 iken, kontrol grubunda 0.13 ± 0,61 olarak tespit edildi. Benzer şekilde Binükleotid (BN) hücre oranları karşılaştırıldığında vaka ve kontrol grubunda sırasıyla 0,30 ±0,18 ve 0,12±0,05 idi. Hem mikronukleus hemde binukleotid sayısı bakımından vaka ve kontrol grubu arasında istatiksel bir fark mevcuttu (p=0.00). Sonuç: Matbaa sanayinde çalışanlarda normal populasyona göre ağız mukoza hücrelerinde MN ve BN oranlarının arttığı gözlenmiştir. Bu bulguların işçi sağlığı yönünden dikkate alınması uygun olabilir.

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Cite This Article

YILDIRIM, A., YILDIRIM, M. S. (2011). Determination of the incidance of micronucleus and binucleotids in the buccal mucosa of printing industry workers. Tıp Araştırmaları Dergisi, Cilt: 9 - Sayı: 1, 25–28. https://ajindex.com/articles/361835

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References (14)

  1. Clarkson, TW. Principles of risk assessment. Adv. Dent. Res 1992; 6: 22 – 27
  2. Köteles G.J. (8-12 November) Use of human Lymphocytic micronuclei in dedection of clastogenic effects. IAEA/UNEP Seminar for Africa, Europe, Middle East and the Mediterranean on Radiobiological Techniques in the Comparative Estimation of Carsinogenic Induction by Chemical Pollutants and Low- dose Radiation. 1993; Nairobi, 1 – 16
  3. Gomez-arroyo S, Sanchez YD, Perez MAM, Villalobos-Pietrini R, Rodriguez JDL. Cytogenetic biomonitoring in a mexican floriculture worker group exposed to pesticides. Mutat. Res. 2000; 466:117–124
  4. Garaj-Vrhovac V, Zeljezic D. Assesment of genome damage in a population of Croatian workers employed in pesticide production by chromosomal aberration analysis, micronucleus assay and comet assay. J. Appl. Toxicol. 2002; 22,249-255
  5. Eroğlu HE. Mesane Kanserli Hastaların Doku Örneklerinde Propolis ve Mitomisin-C’nin Mikronükleus, Kardeş Kromatid Değişimi, Kromozom Analizi ve Mitotik İndeks Parametrelerine Etkisinin Karşılaştırılması. Yüksek Lisans Tezi, Erciyes Ün. Sağlık Bilimleri Enstitüsü, Kayseri.2004; 1- 89
  6. Matsuno T, Jung SK, MatsumotoY, Saito M, Morikawa J. Preferential Cytotoxicity to Tumor Cells of 3,5-Diprenyl-4- Hydroxycinnamic Acid (Artepillin C) Isolated from Propolis. Anticancer Research 1997; 17:3565-3568
  7. Franco EL, Kowalski LP, Oliveira BV, Curado MP, Pereira RN, Silva ME, et al. Risk factors for oral cancer in Brazil: a case- control study. Int J Cancer 1989;43:992-1000
  8. Surralles, J, Xamena, N, Creus, A, Marcosb R. The suitability of the micronucleus assay in human lymphocytes as a new biomarker of excision repair. Mutat. Res. 1995; 342: 43-59
  9. A.Çelik, T.Çavaş, S.Ergene-Gözükara, Cytogenetic biomonitoring in petrol station attendants: micronucleus test in exfoliated buccal cells, Mutagenesis 2003; 18: 417-421
  10. P.E. Tolbert, C.M. Shy, J.W. Allen, Micronuclei and other nuclear abnormalities in buccal smears: methods and development, Mutat. Res. 1992; 271: 69–77
  11. Palmer K, İnskip H, Martyn C, Coggon D. Dementia and occupational exposure to organic solvents. Occup Environ Med. 1998; 55: 712–715
  12. Boffetta P, De Vocht F. Occupation and the risk of non-Hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev. 2007; 16: 369– 372
  13. Bulbulyan MA, Ilychova SA, Zahm SH, Astashevsky SV, Zaridze DG. Cancer mortality among women in the Russian printing industry. Am J Ind Med. 1999; 36: 166–171
  14. Purdham JT, Bozek PR, S