Journals / Tıp Araştırmaları Dergisi / 2014 / Cilt: 12 - Sayı: 3

Investigation of Thyroid Otoimmunity in Patients with Urticaria

Ürtikerli Hastalarda Tiroid Otoimmunitesinin Araştırılması

Pages
103–107
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Understanding this relationship will be potentially useful in evaluating the treatment benefits of either thyroidhormones or anti-thyroid drugs in resistant cases of CIU

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: An autoimmune etiology has been suggested in up to one-third of cases of chronic idiopathic urticaria (CIU).
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Key Findings & Data:Material and Methods: Seventy nine patients aged 14–70 years, who met criteria for urticaria, and 40 agedmatched healthy controls (10 males and 30 females) were participated in this study.
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Conclusion & Impact:Understanding this relationship will be potentially useful in evaluating the treatment benefits of either thyroidhormones or anti-thyroid drugs in resistant cases of CIU
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: An autoimmune etiology has been suggested in up to one-third of cases of chronic idiopathic urticaria (CIU). It is known that thyroid autoimmunity may be associated with urticaria. The objective of our present study was to verify the prevalence of thyroid antibodies in the patients with urticaria. Material and Methods: Seventy nine patients aged 14–70 years, who met criteria for urticaria, and 40 agedmatched healthy controls (10 males and 30 females) were participated in this study. Serum thyroid-stimulating hormone (TSH), free T3, free T4, anti-peroxidase (TPO), and anti-thyroglobulin (anti-Tg) antibody levels were measured. Results: The total ATA positive rate was 26.7% in the CIU group. The prevalence of anti-TG, and anti-TPO were 10.7 %, 17.9 % respectively. The prevalance of anti TPO was significantly higher in patients with CIU than controls (p=0,023). The total ATA positive rate was %10 in the acute urticaria. Conclusion: We determined that the prevalance of thyroid antibodies was significantly higher in our CIU patients. It is important to evaluate the relationship between thyroid auto-immunity and thyroid function in CIU patients. Understanding this relationship will be potentially useful in evaluating the treatment benefits of either thyroidhormones or anti-thyroid drugs in resistant cases of CIU

Özet

Amaç: Otoimmün etyoloji kronik idiopatik ürtikerli (KİÜ) hastaların üçte birinde gösterilmiştir. Tiroid otoimmünitesinin ürtikerle ilişkili olabileceği bilinmektedir. Çalışmamızın amacı ürtikerli hastalarda tiroid otoantikorlarının sıklığını doğrulamaktı. Gereç ve Yöntem: Ürtiker tanısı konulan yaşları 14-70 arasındaki 79 hasta ve 40 sağlıklı kontrol (10 erkek, 30 kadın) çalışmaya katıldı. Serum tiroid stimulan hormon (TSH), serbest T3, serbest T4, anti-peroksidaz (antiTPO) ve anti-tiroglobulin (anti-TG) antikor seviyeleri ölçüldü.Bulgular: Anti-tiroid otoantikor (ATA) pozitifliği kronik ürtikerli grupta % 26,7 idi. Anti-TG ve anti-TPO pozitifliği sırasıyla %10,7 ve %17,9 idi. Anti-TPO sıklığı kronik ürtikerli grupta kontrol grubundan istatistiksel olarak daha yüksekti (p=0,023). Anti-tiroid otoantikor pozitifliği akut ürtikerli grupta %10 idi. Sonuç: Bu çalışmada kronik idiopatik hasta grubumuzda tiroid otoantikor sıklığını yüksek oranda saptadık.Kronik idiopatik ürtikerli hastalarda tiroid otoimmünitesi ve tiroid fonksiyonları arasındaki ilişkiyi değerlendirmek önemlidir. Bu ilişkinin anlaşılması tiroid hormonları veya anti-tiroid ilaçların tedaviye dirençli olgulardaki yararlarını değerlendirmede yol gösterici olacaktır

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Cite This Article

TOPAL, İ. O., DUMAN, H., GÜNGÖR, Ş., ÜLKÜMEN¹, P. K., DURMUŞCAN, M., TOPAL, Y. (2014). Investigation of Thyroid Otoimmunity in Patients with Urticaria. Tıp Araştırmaları Dergisi, Cilt: 12 - Sayı: 3, 103–107. https://ajindex.com/articles/361815

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References (18)

  1. Champion RH. Urticaria: then and now. Br J Dermatol 1988; 119:427-436
  2. Greaves M.W. Autoimmune urticaria, Clinical Reviews in Allergy and Immunology 2002; 23: 171-183
  3. Nettis E, Pannofino A, Aprile CD, Ferrannını A, Tursi A. Clinical and laboratory ınvestigations: Clinical and etiological aspects in urticaria and anjioedema. British Journal of Dermatology 2003; 148: 501-506
  4. İşcimen A, Göksügür N. Urtiker ve anjioodem-I etyoloji ve patogenez. Dermatose 2002; 1: 43-51
  5. Schaefer P. Urticaria: Evaluation and Treatment. American Family Physician 2011; 83: 1078-1084
  6. Aydın F, Yüksel EP. Otoiimmmün ürtikerde tanı ve tedavi. Turkiye Klinikleri J Dermatol-Special Topics 2012; 5: 16-19
  7. Grattan CEH, Sabroe RA, Greaves MW. Chronic Urticaria. J Am Acad Dermatol 2002; 46: 645-657
  8. Leznoff A, Josse RG, Denburge J, Dolovich J: Association of chronic urticaria and anjioedema with thyroid autoimmunity. Arch Dermatol 1983; 119: 636-640
  9. Cebeci F, Topçu E, Onsun N, Kurtulmuş N, Uras A. Autoimmune tyroidit with chronic idiopathic urticaria. Turkderm 2004; 38: 264-267
  10. Gül Ü, Çakmak S, Gönül M, Soylu S, Kılıç A. Kronik ürtikerde tiroid fonksiyon testleri ve tiroid otoantikorları istenmeli mi? Asthma Allergy Immunol. 2009;7:39-43
  11. Monge C, Demarco P, Burman KD, Wartofsky L. Autoimmune thyroid disease and chronic urticaria. Clin Endocrinol (Oxf). 2007; 67: 473-475
  12. Gangemi S, Saitta S, Lombardo G, Patafi M, Benvenga S. Serum thyroid autoantibodies in patients with idiopathic either acute or chronic urticaria. J Endocrinol Invest. 2009; 32: 107-110
  13. Dreskin SC, Andrews KY. The thyroid and urticaria. Curr Opin Allergy Clin Immunol. 2005; 5: 408-412
  14. Verneuil L, Leconte C, Ballet JJ, Coffin C, Laroche D, Izard JP, Reznik Y, Leroy D Association between chronic urticaria and thyroid autoimmunity: a prospective study involving 99 patients. Dermatology 2004; 208: 98-103
  15. Karadağ AS, Bilgili SG, Çalka Ö, Akdeniz N, Özkol HU, Aktar S. Akut Ürtikerli Yatan Hastaların Klinik Olarak Değerlendirilmesi. Turkderm 2011; 45: 179-83
  16. Utaş S. Kronik ürtiker etyopatogenezi ve tedavi yaklaşımları. Turkiye Klinikleri J Int Med Sci. 2005, 1: 22-27
  17. Rumbyrt JS, Katz JL, Schocket AL. Resolution of chronic urticaria in patients with thyroid autoimmunity. J Allergy Clin Immunol. 1995; 96: 901-905
  18. Gulec M, Kartal O, Caliskaner AZ, Yazici M, Yaman H, Ozturk S, Sener O. Chronic urticaria in patients with autoimmune thyroiditis: significance of