Journals / Tıp Araştırmaları Dergisi / 2015 / Cilt: 13 - Sayı: 3

Does Metabolıc Syndrome Increas Cancer Risk?

Metabolik Sendromda Kanser Riski Artar mı?

Pages
147–150
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

A multidisciplinary approach involving nutrition, exercise, and stres reduction may be an opportunity to limit the insulin resistant state and improve cancer outcomes

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Obesity, hypertension, diabetes mellitus are all related in both genetical and environmental properties in last decades.
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Key Findings & Data:Cancer is stil second cause of mortality in the western world and in our country.
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Conclusion & Impact:A multidisciplinary approach involving nutrition, exercise, and stres reduction may be an opportunity to limit the insulin resistant state and improve cancer outcomes
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Obesity, hypertension, diabetes mellitus are all related in both genetical and environmental properties in last decades. Cancer is stil second cause of mortality in the western world and in our country. Most of the components of metabolic syndrome have been associated with the development of neoplasm. The metabolic syndrome and visceral obesity have an increasing prevalence and incidence in the general population. Obesity has recently been linked to mortality in the majority of cancers. A multidisciplinary approach involving nutrition, exercise, and stres reduction may be an opportunity to limit the insulin resistant state and improve cancer outcomes

Özet

Genetik ve çevresel etmenlerin birlikte rol aldığı metabolik sendrom ve ilişkili sorunlardan obezite, hipertansiyon ve diyabetes mellitus dünya genelinde giderek artan oranda görülmektedir. Kanser ise tüm dünyada ve ülkemizde kardiyovasküler hastalıklara bağlı mortaliteden sonra ikinci sırada ölüm nedenidir. Metabolik sendrom bileşenlerinin çoğu tümör gelişimi ile bağlantılıdır. Düzenli beslenme ve egzersiz ve stresi azaltmayı kapsayan multidisipliner bir yaklaşım, insülin direncini ve metabolik sendrom sıklığını azaltmada ve kanser prognozunu iyileştirmede oldukça önemli faydalar sağlayabilir

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Cite This Article

BALKAN, F., USLUOĞULLARI, C. A. (2015). Does Metabolıc Syndrome Increas Cancer Risk?. Tıp Araştırmaları Dergisi, Cilt: 13 - Sayı: 3, 147–150. https://ajindex.com/articles/361629

References (13)

  1. Vecchione L, Gargiu E, Borgiani P, et al. Genotyping OLR1 Gene: A Genomic Biomarker for Cardiovascular Diseases. Recent Pat Cardiovasc Drug Discov 2007; 2:147-151
  2. Freeman MW. Scavenger receptors in atherosclerosis. Curr Opin Hematol 1997; 4:41- 47
  3. Tate Shin-I. Oxidized low-density lipoprotein receptor, LOX-1, on the endothelial cell- The receptor structure and functions of LOX-1 in atherogenesis. J Biol Macromol 2007; 7(2): 11-22
  4. Steinbrecher UP. Receptors for oxidized low density lipoprotein. Biochim Biophys Acta 1999; 1436:279-298
  5. Chen M, Kakutani M, Minami M, et al. Increased expression of lectin-like oxidized low density lipoprotein receptor-1 in initial atherosclerotic lesions of Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol 2000; 20:1107-1115
  6. Moriwaki H, Kume N, Kataoka H, et al. Expression of lectin-like oxidized low density lipoprotein receptor-1 in human and murine macrophages: upregulated expression by TNF-?. FEBS Lett. 1998; 440:29-32
  7. Aoyama T, Chen M, Fujiwara H, Masaki T, Sawamura T. LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells. FEBS Lett. 2000; 467:217-220
  8. Falconi M, Biocca S, Novelli G, Desideri A. Molecular dynamics simulation of human LOX-1 provides an explanation for the lack of OxLDL binding to the Trp150Ala mutant. BMC Structural Biology 2007; 7:73
  9. Cominacini L, Pasini AF, Garbin U, et al. Oxidized low density lipoprotein (ox-LDL) binding to ox LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species. J Biol Chem 2000; 275: 12633- 12638
  10. Li D, Mehta JL. Upregulation of endothelial receptor for oxidized LDL (LOX-1) by oxidized LDL and implications in apoptosis of human coronary artery endothelial cells: evidence from use of antisense LOX-1 mRNA and chemical inhibitors. Arterioscler Thromb Vasc Biol. 2000; 20:1116-1122
  11. Cominacini L, Rigoni A, Fratta PA, et al. The binding of oxidized low-density lipoprotein (oxLDL) to ox-LDL receptor- 1 in endothelial cells reduces the intracellular concentration of nitric oxide through an increased production of superoxide. J Biol Chem. 2001; 276:13750-13755
  12. Aoyama T, Sawamura T, Furutanı Y, et al. Structure and chromosomal assignment of the human lectin-like oxidized low-density-lipoprotein receptor-1 (LOX-1) gene. Biochem. J 1999; 339:177-184 (Printed in Great Britain)
  13. Chen M, Narumiya S, Mas