Evaluation of ischemic stroke and Chalamydia pneumonia

Key Findings & Data:In this study we measured serum IgG antibody titers against chlamydia pneumoniae in patients with ischemic stroke by microimmunofluorecense and compared the seropositivity with the control group. 62 patients with ischemic stroke and 60 cases without any vascular pathology were included into the study.

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Conclusion & Impact:Further epidemiological studies of the effect of this infection on stroke are needed.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:İskemi · Risk faktörleri · Serebrovasküler olay

Abstract

Ischemic stroke and its complications are remarkably associated with high mortality and morbidity rates. Recently, gaining further knowledge concerning the pathophysiology of atherosclerosis, infectious agents became of interest in the etiology of atherosclerosis. During the last decade the newly recognized, Gram (-), obligatory intracellular bacteria, chalamyclia pneumoniae (TWAR), was encountered at the atheromatous plaques and has been detected by microimmunofluorescence (MIF), immunocytochemistry (ICC), polymerase chain reaction (PCR) and electron microscopy (EM). In this study we measured serum IgG antibody titers against chlamydia pneumoniae in patients with ischemic stroke by microimmunofluorecense and compared the seropositivity with the control group. 62 patients with ischemic stroke and 60 cases without any vascular pathology were included into the study. There was statistical significance between patient and control group according to IgG seropositivity (p=0.0037). The presence of atherosclerotic risk factors at ischemic stroke group and control cases and their association with IgG type antibodies against chlamydia pneumoniae were not significant. Additionally association of IgG seropositivity with the nature of the cerebral lesions were not meaningful. Further epidemiological studies of the effect of this infection on stroke are needed.

Özet

İskemik strok çok önemli bir mortalite ve morbidite nedenidir. Son zamanlarda ateroskleroz fizyopatolojisinin aydınlatılması ile enfeksiyöz etyoloji önem kazanmıştır. Son yıllarda gram (-), intrasellüler yaşam siklusu olan ve yeni tanımlanan bir klamidya türü K. Pnömonya (TWAR), aterom plaklarında; mikroimmunofloresan (MlF),immununohistokimyasal (ICC), polimerase chain reaction (PCR) ve elektron mikroskobu ile gösterilmiştir. Bu çalışmada 62 iskemik strok'lu hastada klamidya pnömonyaya karşı gelişen IgG tipi antikorların varlığı mikroimmunofloresan yöntemi ile araştırılmış herhangi bir vasküler şikayeti olmayan 60 kontrol grubu ile karşılaştırılmıştır. Iskemik strok geçiren hastalarda IgG tipi antikorların varlığı kontrol grubuna göre anlamlı ölçüde yüksek bulunmuştur (p<0.005). Hasta ve kontrol grubunda aterosklerotik risk faktörlerinin varlığı araştırılmış ve her iki grupta risk faktörleri ile klamidya pnömonyaya karşı gelişen IgG tipi antikorların varlığı açısından bir ilişki bulunmamıştır. Ayrıca hasta grubunda serebral İezyonunnatürü ile klamidya pnömonyaya karşı gelişen IgG antikor varlığı arasında da anlamlı bir ilişki bulunmamıştır. Bu infeksiyonun strok üzerindeki etkileri için daha geniş epidemiolojik çalışmalara ihtiyaç vardır.

Keywords

İskemi Risk faktörleri Serebrovasküler olay Chlamydia pneumoniae Ischemia Risk Factors Cerebrovascular Accident

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Cite This Article

MISIRLI, H., ERKAL, H., SOMAY, G., ERENOĞLU, N. Y. (2003). Evaluation of ischemic stroke and Chalamydia pneumonia. Türk Serebrovasküler Hastalıklar Dergisi, Cilt: 9 - Sayı: 1, 7–11. https://ajindex.com/articles/357837

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