SavedAdd your journal

Journals / Astım Allerji İmmünoloji / 2021 / Cilt: 19 - Sayı: 1

Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases

TUBA ERDOĞAN
Nazife BİLGE
Timuçin KAŞİFOĞLU
Pages
32–37
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This may be the result of recent advances in the innate immune sensing system.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Autoinflammatory diseases are driven by abnormal activation of the innate immune system.
📊
Key Findings & Data:Although allergic diseasesare known to be mediated by the T helper 2 response, new mechanisms are put forward about the activation of innate immunityduring exposure to allergens in recent years.
💡
Conclusion & Impact:This may be the result of recent advances in the innate immune sensing system.
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: Autoinflammatory diseases are driven by abnormal activation of the innate immune system. Although allergic diseasesare known to be mediated by the T helper 2 response, new mechanisms are put forward about the activation of innate immunityduring exposure to allergens in recent years. Familial Mediterranean fever (FMF) and Behçet’s disease (BD) are the commonly seenautoinflammatory diseases in Turkey. It was aimed to determine the prevalence of allergic diseases in BD and FMF and contribute toexplaining the relationship between autoinflammation and allergic diseases in this survey.Materials and Methods: The study included 42 patients with BD, 40 with FMF, 20 with other rheumatic diseases, and 20 healthycontrols who had volunteered for allergic evaluation. Patients were questioned about allergic diseases such as asthma, allergic rhinitis,atopic dermatitis, venom allergy, and food-drug allergy. The same prick test panel was used for all patients to investigate the presenceof atopy.Results: Although the rate of allergic diseases and the blood eosinophil rate were significantly higher in patients with FMF and Behçet’sdisease, which are commonly seen as autoinflammatory diseases, atopy rates were similar in all groups. The prevalence of allergic rhinitisand any allergic diseases was significantly higher in the FMF and BD groups (p: 0.03 and p: 0.02, respectively). In the multiple logisticregression model of the presence of any allergic disease, none of the factors was associated with allergic diseases.Conclusion: The prevalence of allergic diseases in patients with FMF and BD was found to be higher than in those with other rheumaticdiseases and the control group but atopy rates were similar in all groups. The autoinflammatory diseases are not protective in terms ofallergic sensitization and allergic rhinitis. This may be the result of recent advances in the innate immune sensing system.

🔖

Cite This Article

ERDOĞAN, T., BİLGE, N., KAŞİFOĞLU, T. (2021). Prevalence of Allergic Diseases in Patients with Common Autoinflammatory Diseases. Astım Allerji İmmünoloji, Cilt: 19 - Sayı: 1, 32–37. https://ajindex.com/articles/351215

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. De Torre-Minguela C, Mesa Del Castillo P. The NLPR3 and pyrin inflammasomes: implications in the pathophysiology of autoinflammatory diseases. Front Immunol 2017;8:43
  2. Campbell L, Raheem I, Malemud CJ. The relationship between NALP3 and autoinflammatory syndromes. Int J Mol Sci 2016; 17 (5):725
  3. Macaluso F, Nothnagel M, Parwez Q, Petrasch-Parwez E, Bechara FG, Epplen JT et al. Polymorphisms in NACHTLRR (NLR) genes in atopic dermatitis. Exp Dermatol. 2007; 16(8):692-8
  4. Herberth G, Offenberg K, Rolle-Kampczyk U, Bauer M, Otto W, Röder S, Grützmann K, Sack U, Simon JC, Borte M, von Bergen M, Lehmann I; LINA Study Group. Endogenous metabolites and inflammasome activity in early childhood and links to respiratory diseases. J Allergy Clin Immunol. 2015; 136(2):495- 7
  5. Madouri F, Guillou N, Fauconnier L, Marchiol T, Rouxel N, Chenuet P, et al. Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation. J Mol Cell Biol. 2015; 7(4):351-65
  6. Jang HY, Koo JH, Lee SM, Park BH. Atopic dermatitis-like skin lesions are suppressed in fat-1 transgenic mice through the inhibition of inflammasomes. Exp Mol Med. 2018: 13; 50(6):73
  7. Gül A. Pathogenesis of Behçet’s disease: autoinflammatory features and beyond. Semin Immunopathol. 2015; 37(4):413-8
  8. Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, et al. TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma. Sci Transl Med. 2015;7(301):301ra129
  9. Verhoef CM, Van Roon JA, Vianen ME. Mutual antagonism of rheumatoid arthritis and hay fever: a role for type 1/type 2 cell balance. Ann Rheum Dis 1998; 57:275-80
  10. Oro AS, Guarino TJ, Driver R. Regulation of disease susceptibility: decreased prevalence of IgE- mediated allergic disease in patients with multiple sclerosis. J Allergy Clin Immunol 1996; 97:1402-8
  11. Lai NS, Tsai TY, Koo M, Lu MC. Association of rheumatoid arthritis with allergic diseases: A nationwide population-based cohort study. Allergy Asthma Proc. 2015;36(5):99-103
  12. Maeda K, Caldez MJ, Akira S. Innate immunity in allergy. Allergy. 2019; 74(9):1660-1674
  13. Sackesen C, Bakkaloglu A, Sekerel BE, Ozaltin F, Besbas N, Yilmaz E, et al. Decreased prevalence of atopy in paediatric patients with familial Mediterranean fever. Ann Rheum Dis. 2004; 63(2):187-90
  14. Aydoğmuş Ç, Ayaz NA, Çakan M, Çipe F, Topal N, Öner ÖB et al. Is there any difference regarding atopy between children with familial M