Journals / Dicle Tıp Dergisi / 2010 / Cilt: 37 - Sayı: 3

Impact of metabolic syndrome on ST segment resolution after thrombolytic therapy for acute myocardial infarction

Akut miyokard infarktüslü hastalarda trombolitik tedavi sonrası ST segment gerilemesi üzerine metabolik sendromun etkisi

Pages
276–281
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This finding may contribute to the higher morbidity and mortality of patients with metabolic syndrome

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: It has been shown that metabolic syndrome is associated with poor short-term outcome and poor long-term survival in patients with acute myocardial infarction.
📊
Key Findings & Data:Materials and methods: We retrospectively analyzed 161 patients, who were admitted to our clinics with acute ST-elevated-myocardial infarction and received thrombolytic therapy within 12 hours of chest pain.
💡
Conclusion & Impact:This finding may contribute to the higher morbidity and mortality of patients with metabolic syndrome
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: It has been shown that metabolic syndrome is associated with poor short-term outcome and poor long-term survival in patients with acute myocardial infarction. We aimed to investigate the effect of metabolic syndrome on ST segment resolution in patients received thrombolytic therapy for acute myocardial infarction. Materials and methods: We retrospectively analyzed 161 patients, who were admitted to our clinics with acute ST-elevated-myocardial infarction and received thrombolytic therapy within 12 hours of chest pain. Metabolic syndrome was diagnosed according to National Cholesterol Education Program Adult Treatment Panel III criteria. Resolution of ST segment elevation was assessed on the baseline and 90-minute electrocardiograms. ST segment resolution ≥70% was defined as complete resolution. Results: Metabolic syndrome was found in 56.5% of patients. The proportion of patients with metabolic syndrome who achieved complete ST segment resolution after thrombolysis was significantly lower than that of patients without metabolic syndrome (32.9% versus 58.6%, p=0.001). On multivariate analysis metabolic syndrome was the only independent predictor of ST segment resolution (p=0.01, Odds ratio=2.543, %95 CI:1.248-5.179) Conclusion: The patients with metabolic syndrome had lower rates of complete ST segment resolution after thrombolytic therapy for acute myocardial infarction. This finding may contribute to the higher morbidity and mortality of patients with metabolic syndrome

Özet

Amaç: Akut miyokard infarktüslü hastalarda, metabolik sendromun kısa dönem sonuçları ve uzun dönem sağkalım üzerine olumsuz etkileri gösterilmiştir. Çalışmamızdaki amacımız akut miyokard infarktüsü nedeni ile trombolitik alan hastalarda metabolik sendromun ST segment gerilemesi üzerine etkisini incelemektir. Gereç ve yöntemler: Akut miyokard infarktüsü ile başvuran ve göğüs ağrısının ilk 12 saati içinde trombolitik tedavi alan 161 hasta retrospektif olarak incelendi. Metabolik sendrom tanısı Ulusal Kolesterol Eğitim Programı Üçüncü Erişkin Tedavi Paneli kılavuzuna göre konuldu. Trombolitik tedavi öncesi ve 90. dakikada çekilen elektrokardiyografiler ST segment gerilemesi açısından değerlendirildi. Komplet ST segment gerilemesi ≥%70 olarak belirlendi. Bulgular: Çalışmaya alınan 161 hastanın 91’inde (%56.5) metabolik sendrom saptandı. Trombolitik tedavi sonrası komplet ST segment gerilemesi oranı metabolik sendromlu hastalarda metabolik sendromu olmayan hastalara göre daha düşük bulundu (%32.9-% 58.6, p=0.001). Çok değişkenli analizde metabolik sendrom ST segment gerilemesini öngördüren tek bağımsız faktör olarak bulundu (p=0.01, Odds oranı=2.543, %95 CI:1.248-5.179). Sonuç: Çalışmamızda akut miyokard infarktüs ile başvuran hastalardan metabolik sendromu olanlarda trombolitik tedavi sonrası komplet ST segment gerilemesi metabolik sendromu olmayanlara göre daha düşük oranda bulundu. Bu durum bu hastalarda akut miyokard infarktüsündeki artmış morbidite ve mortaliteye katkıda bulunuyor olabilir.

🔖

Cite This Article

YAŞAR, A. S., BAŞAR, N., KASAPKARA, A., YĞKSEL, İ. Ö., İPEK, G., BİLGE, M. (2010). Impact of metabolic syndrome on ST segment resolution after thrombolytic therapy for acute myocardial infarction. Dicle Tıp Dergisi, Cilt: 37 - Sayı: 3, 276–281. https://ajindex.com/articles/349878

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Grundy SM. Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 1999;83:25F-29F
  2. Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486–97
  3. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001;24.683–9
  4. Girman CJ, Rhodes T, Mercuri M, et al. 4S Group and the AFCAPS/TexCAPS Research Group. The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Am J Cardiol 2004;93:136–41
  5. Turhan H, Yasar AS, Basar N, Bicer A, Erbay AR, Yetkin E. High prevalence of metabolic syndrome among young women with premature coronary artery disease. Coronary Artery Dis 2005;16.37–40
  6. Malik S, Wong ND, Franklin SS, et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004;110:1245–50
  7. Zeller M, Steg PG, Ravisy J, et al. Observatiore des Infarctus de Cote-d’Or Survey working Group. Prevalence and impact of metabolic syndrome on hospital outcomes in acute myocardial infarction. Arch Intern Med 2005;165:1192–8
  8. Takeno M, Yasuda S, Otsuka Y, et al. Impact of metabolic syndrome on the long-term survival of patients with acute myocardial infarction. Circ J 2008;72.415–9
  9. Schroder R. Prognostic impact of early ST-segment resolution in acute ST-elevation myocardial infarction. Circulation 2004;110:e506–10
  10. Krucoff MW, Johanson P, Baeza R, Crater SW, Dellborg M. Clinical utility of serial and continuous ST-segment recovery assessment in patients with acute ST- elevation myocardial infarction: assessing the dynamics of epicardial and myocardial reperfusion. Circulation 2004;110:e533–9. 11. de Lemos JA, Antman EM, Giugliano RP, et al. for the TIMI 14 Investigators. ST segment resolution and infarct-related artery patency and flow after thromblytic therapy. Am J Cardiol 2000;85.299–304
  11. Dissmann R, Schroder R, Busse U, et al. Early assessment of outcome by ST-segment analysis after thrombolytic therapy in acute myocardial infarction. Am Heart J 1994;128:851