Journals / MN Kardiyoloji / 2010 / Cilt: 17 - Sayı: 1

Association between metabolic syndrome and extent of coronary artery disease in patients with acute myocardial infarction

Akut miyokard infarktüslü hastalarda metabolik sendrom ve koroner arter hastalığı yaygınlığı arasındaki ilişki

Pages
9–13
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This finding may contribute to the higher mortality reported in patients with metabolic syndrome.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It is known that cardiovascular events and mortality are increased in pateints with metabolic syndrome.
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Key Findings & Data:Material and Method: We retrospectively analyzed 157 patients who were admitted to our clinics with acute ST-elevation myocardial infarction and received thrombolytic therapy within 12 hours of chest pain.
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Conclusion & Impact:This finding may contribute to the higher mortality reported in patients with metabolic syndrome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: It is known that cardiovascular events and mortality are increased in pateints with metabolic syndrome. We aimed to examine the effect of metabolic syndrome on extent of coronary artery disease in patients with acute myocardial infarction. Material and Method: We retrospectively analyzed 157 patients who were admitted to our clinics with acute ST-elevation myocardial infarction and received thrombolytic therapy within 12 hours of chest pain. Metabolic syndrome was diagnosed according to National Cholesterol Education Program Adult Treatment Panel III criteria. Stenosis in the coronary arteries were graded and the number of vessels with significant stenosis (≥70%) was determined. Gensini score was used to assess the extent of atherosclerosis. Results: Total Gensini score of patients with metabolic syndrome was significantly higher than that saof patients without metabolic syndrome (49.67±31.04 vs 39.6±26.23, p=0.029). There was no significant difference between groups regarding with three vessel disease. Positive correlation between metabolic syndrome and Gensini score was found (r=0.180, p=0.03). Conclusion: We have found that metabolic syndrome was associated with more extensive coronary artery disease in patients with acute ST elevation myocardial infarction. This finding may contribute to the higher mortality reported in patients with metabolic syndrome.

Özet

Amaç: Metabolik sendromlu hastalarda kardiyovasküler olay sıklığı ve mortalite oranlarında artış olduğu bilinmektedir. Çalışmamızdaki amacımız akut miyokard infarktüsü ile başvuran hastalarda metabolik sendromun koroner arter hastalığı yaygınlığına etkisini incelemektir. Gereç ve Yöntem: Akut ST yükselmeli miyokard infarktüsü ile başvuran ve göğüs ağrısının ilk 12 saati içinde trombolitik tedavi alan 157 hasta retrospektif olarak incelendi. Metabolik sendrom tanısı Ulusal Kolesterol Eğitim Programı Üçüncü Erişkin Tedavi Paneli kılavuzuna göre konuldu. Koroner arterlerdeki darlık derecelendirildikten sonra önemli (≥ %70) darlığı olan koroner damar sayısı tespit edildi. Ateroskleroz yaygınlığı Gensini skorlaması ile değerlendirildi. Bulgular: Metabolik sendromlu hastalarda toplam Gensini skoru metabolik sendromu olmayan hastalara göre istatistiksel olarak anlamlı derecede daha yüksek bulundu (49,67±31,04 ve 39,6±26,23, p=0,029). Üç damar hastalığı bulunması açısından gruplar arasında fark saptanmadı. Metabolik sendrom skoru ve Gensini skoru arasında pozitif korelasyon izlendi (r=0,180, p=0,03). Sonuç: Çalışmamızda metabolik sendromun akut ST yükselmeli miyokard infarktüsü ile başvuran hastalarda daha yaygın koroner arter hastalığı ile ilişkili olduğunu gösterdik. Bu durum bu hastalardaki artmış mortaliteye katkıda bulunuyor olabilir.

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Cite This Article

YAŞAR, A. S., KASAPKARA, A., YÜKSEL, İ. Ö., BAŞAR, N., BİLGE, M. (2010). Association between metabolic syndrome and extent of coronary artery disease in patients with acute myocardial infarction. MN Kardiyoloji, Cilt: 17 - Sayı: 1, 9–13. https://ajindex.com/articles/297915

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