Journals / Dicle Tıp Dergisi / 2016 / Cilt: 43 - Sayı: 2

Predictive value of Neutrophil/Lymphocyte Ratio for the Diagnosis and Severity of Disease in Acute Appendicitis

Akut Apandisit Olgularında Nötrofil/Lenfosit Oranının Tanıda ve Hastalığın Şiddetini Belirlemedeki Prediktif Değeri

Pages
279–284
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: In addition to physical examination and other diagnostic methods, NLR can be considered as a useful auxiliary tool for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Our aim was to investigate the value of neutrophil/lymphocyte ratio for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis.
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Key Findings & Data:Methods: The medical records of 162 patients having undergone appendectomies between January 2013 and September 2014 including age, gender, preoperatively assessed C-reactive protein (CRP), white blood cell (WBC), neutrophil (NEU), lymphocyte, and neutrophil/lymphocyte ratio (NLR) values were retrospectively evaluated, compared with the postoperative histopathological findings, and statistically analyzed.
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Conclusion & Impact:Conclusions: In addition to physical examination and other diagnostic methods, NLR can be considered as a useful auxiliary tool for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis.
🔬Design:Research Article
📍Scope:2013 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: Our aim was to investigate the value of neutrophil/lymphocyte ratio for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis. Methods: The medical records of 162 patients having undergone appendectomies between January 2013 and September 2014 including age, gender, preoperatively assessed C-reactive protein (CRP), white blood cell (WBC), neutrophil (NEU), lymphocyte, and neutrophil/lymphocyte ratio (NLR) values were retrospectively evaluated, compared with the postoperative histopathological findings, and statistically analyzed. Results: The study group consisted of 97 (59.9%) men, and 65 (40.1%) women with a median age of 36.01 (1890). Histopathological examinations revealed normal appendix in 21 (12.96%), and acute appendicitis in 141 (87.04%) patients. Appendiceal gangrene/perforation rate was 25.31%. Lymphocyte counts were decreased, while CRP, WBC, NEU, and NLR values were increased in acute appendicitis (p<0.05). NLR >=4.0 was associated with 16.9 times increased possibility of acute appendicitis [p<0.01, Odds ratio (OR):16.864, 95% Confidence interval (CI):4.696-60.568]. In cases with NLR>=4.5, it was detected that the risk of appendiceal gangrene/perforation was 3.2 times higher [p<0.01, OR:3.258, 95% CI: 1.4687.228]. Conclusions: In addition to physical examination and other diagnostic methods, NLR can be considered as a useful auxiliary tool for the diagnosis of acute appendicitis, and for the prediction of gangrenous/perforated appendicitis.

Özet

Amaç: Akut apandisit olgularında ameliyat öncesi rutin hemogram tetkikinde saptanan nötrofil/lenfosit oranının (NLO) tanı koymada ve gangrene/perfore apandisiti ön görmedeki etkisini incelemeyi amaçladık. Yöntemler: Ocak 2013 ile Eylül 2014 arasında apendektomi uygulanan 162 hastanın yaş, cinsiyet, c-reaktif protein (CRP), lökosit, nötrofil, lenfosit sayısı ve NLO ile ameliyat sonrası histopatolojik inceleme sonuçlarını içeren verileri retrospektif olarak incelendi ve istatistiksel olarak değerlendirildi. Bulgular: Çalışma grubundaki hastaların 97'si (%59,9) erkek ve 65'i (%40,1) kadındı. Ortalama yaş 36,01 hesaplandı. Ameliyat sonrası patoloji sonuçlarına göre 21 (%12,96) hastada normal apendiks ve 141 (%87,04) hastada akut apandisit saptandı. 41 (%25,31) hastada ise gangrene/perfore apandisit varlığı gözlendi. Akut apandisit olgularında lenfosit sayısı anlamlı derecede düşük iken CRP düzeyleri, lökosit sayısı, nötrofil sayısı ve NLO'nun anlamlı düzeyde yüksek olduğu gözlendi (p =4,0 olan olgularda akut apandisit tanısı olasılığının 16,9 kat daha yüksek olduğu saptandı [p =4,5 olan olgularda ise apendiseal gangren/perforasyon riskinin 3,2 kat daha yüksek olduğu saptandı [p<0,01; OR: 3,258; %95 CI: 1,468-7,228]. Sonuç: Nötrofil/lenfosit oranı (NLO); akut apandisit tanısı koymada ve gangrene/perfore apandisiti ön görmede fizik muayene ve diğer tanısal yöntemlere yardımcı ve kullanışlı bir değişken olarak kabul edilebilir.

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Cite This Article

EREN, T. T., TOMBALAK, E., BURCU, B., ÖZEMİR, İ. A., LEBLEBİCİ, İ. M., ZİYADE, S., EKİNCİ, Ö., ALİMOĞLU, O. (2016). Predictive value of Neutrophil/Lymphocyte Ratio for the Diagnosis and Severity of Disease in Acute Appendicitis. Dicle Tıp Dergisi, Cilt: 43 - Sayı: 2, 279–284. https://ajindex.com/articles/349459

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