Journals / Dicle Tıp Dergisi / 2006 / Cilt: 33 - Sayı: 3

Comparison of two different radiotherapy schedules in lung cancer patients with brain metastasis

Beyin metastazı yapmış akciğer kanserli hastalarda iki farklı radyoterapi şemasının karşılaştırılması

Pages
134–138
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In conclusion the more economic and easier short irradiation schedule can be preferred collectively in this big patient population.

📌 3 Key Takeaways

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Objective & Hypothesis:Short irradiation schedules are generally preferred in palliative radiotherapy.
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Key Findings & Data:Between January 2001 and December 2004, 28 of 44 consecutive patients who have admitted to our center were treated with a long (3000 cGy/10 fractions/2 weeks) and 16 of 44 patients were treated with a short (2000 cGy/5 fractions/1 week) irradiation schedule.
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Conclusion & Impact:In conclusion the more economic and easier short irradiation schedule can be preferred collectively in this big patient population.
🔬Design:Research Article
📍Scope:2001 Verileri
⚙️Variables:Akciğer neoplazmları · Neoplazm metastazı · Radyoterapi

Abstract

Short irradiation schedules are generally preferred in palliative radiotherapy. Routinely administered a long and a short irradiation schedule have been compared retrospectively in terms of survival and palliative response in lung cancer patients with brain metastasis. Between January 2001 and December 2004, 28 of 44 consecutive patients who have admitted to our center were treated with a long (3000 cGy/10 fractions/2 weeks) and 16 of 44 patients were treated with a short (2000 cGy/5 fractions/1 week) irradiation schedule. Patient characteristics like age, gender, histopathologic diagnosis and performance status were comparable in both groups. Median survival of the whole population was 3,5 months and survival curves were similar in both groups. In conclusion the more economic and easier short irradiation schedule can be preferred collectively in this big patient population.

Özet

Palyatif amaçlı radyoterapide genellikle kısa radyoterapi şemaları tercih edilmektedir. Beyin metastazı yapmış akciğer kanserli hastalarda rutin olarak uygulanan bir uzun ve bir kısa radyoterapi şeması sağ kalım ve palyatif cevap açısından retrospektif olarak karşılaştırıldı. Ocak 2001 ile Aralık 2004 tarihleri arasında merkezimize başvuran akciğer kanseri, beyin metastazlı 44 hastanın 28’i uzun radyoterapi şeması (3000 cGy/10 fraksiyon/2 hafta) ve 16’sı kısa radyoterapi şeması (2000 cGy/5 fraksiyon/1 hafta) ile tedavi edilmişti. Hastaların yaş, cinsiyet, histopatolojik tanı ve performans durumları iki grupta benzerdi. Medyan sağ kalım süresi 3,5 ay olarak izlendi ve sağ kalım eğrisi iki grup arasında benzerdi. Sonuç olarak daha ekonomik ve kolay olan kısa radyoterapi şeması bu büyük bir hasta grubu için yaygın olarak tercih edilebilir.

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Cite This Article

DİRİER, A., KARADAYI, B. (2006). Comparison of two different radiotherapy schedules in lung cancer patients with brain metastasis. Dicle Tıp Dergisi, Cilt: 33 - Sayı: 3, 134–138. https://ajindex.com/articles/349372

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References (15)

  1. Posner JB. Management of central nervous system metastases. Semin Oncol, 1977; 4: 81-91
  2. Perez CA, Brady LW. Principles and Practice of Radiation Oncology, 3rd Edition. Philadelphia: Lippincott-Raven, 1998: 2190
  3. Zimm S, Wampler GL, Stablein D, et al. Intracerebral metastases in solid-tumor patients: natural history and results of treatment. Cancer, 1981; 48: 384-394
  4. Fleckenstein K, Hof H, Lohr F, et al. Prognostic factors for brain metastases after whole brain radiotherapy. Data from a single institution. Strahlenther Onkol, 2004; 180: 268-273
  5. Noordijk EM, Vecht CJ, Haaxma-Reiche H, et al. The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age. Int J Radiat Oncol Biol Phys, 1994; 29: 711-717
  6. Diener-West M, Dobbins TW, Phillips TL. Identification of an optimal subgroup for treatment evaluation of patients with brain metastases using RTOG study 7916. Int J Radiat Oncol Biol Phys, 1989; 16: 669-673
  7. Kocher M, Muller RP, Staar S. et al. Long-term survival after brain metastases in breast cancer. Strahlenther Onkol, 1995; 171: 290-295
  8. Gaspar L, Scott C, Rotman M, et al. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys, 1997; 37: 745-751
  9. Lutterbach J, Bartelt S, Ostertag C. Long-term survival in patients with brain metastases. J Cancer Res Clin Oncol, 2002; 128: 417-425
  10. Lutterbach J, Bartelt S, Stancu E, et al. Patients with brain metastases: hope for recursive partitioning analysis (RPA) class 3. Radiother Oncol, 2002; 63: 339-345
  11. Panagiotou IE, Brountzos EN, Kelekis DA, et al. Cerebral metastases of malignant melanoma: contemporary treatment modalities and survival outcome. Neoplasma, 2005; 52: 150-158
  12. Poon AN, Ho SS, Yeo W, et al. Brain metastasis responding to gefitinib alone. Oncology, 2004; 67: 174-178
  13. Patchell RA, Tibbs PA, Regine WF, et al. Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial. JAMA, 1998; 280: 1485-1489
  14. Bogart JA, Ungureanu C, Shihadeh E, et al. Resection and permanent I-125 brachytherapy without whole brain irradiation for solitary brain metastasis from non-small cell lung carcinoma. J Neurooncol, 1999; 44: 53-57
  15. Andrews DW, Scott CB, Sperduto PW, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain m