This case was presented to emphasize the importance of high suspicion for JAS in FMF cases with atypical joint findings.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:An eight year old male who was detected to have homozygous M694V mutation in the examinations for recurrent abdominal pain and familial history of Familial Mediterranean Fever (FMF) and who was then diagnosed with Juvenile Ankylosing Spondilitis (JAS) upon examination for hip joint pain was presented.
📊
Key Findings & Data:An eight year old male who was detected to have homozygous M694V mutation in the examinations for recurrent abdominal pain and familial history of Familial Mediterranean Fever (FMF) and who was then diagnosed with Juvenile Ankylosing Spondilitis (JAS) upon examination for hip joint pain was presented.
💡
Conclusion & Impact:This case was presented to emphasize the importance of high suspicion for JAS in FMF cases with atypical joint findings.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
An eight year old male who was detected to have homozygous M694V mutation in the examinations for recurrent abdominal pain and familial history of Familial Mediterranean Fever (FMF) and who was then diagnosed with Juvenile Ankylosing Spondilitis (JAS) upon examination for hip joint pain was presented. This case was presented to emphasize the importance of high suspicion for JAS in FMF cases with atypical joint findings.
Özet
Yineleyen karın ağrıları ve ailede Ailevi Akdeniz Ateşi (AAA) öyküsü olması nedeniyle yapılan tetkiklerde M694V homozigot mutasyonu saptanan; kalça eklem ağrısına yönelik yapılan tetkiklerde Juvenil Ankilozan Spondilit (JAS) tanısı alan 8 yaşında olgu sunuldu. Bu olgu, atipik eklem bulguları ile başvuran AAA’lı çocuklarda, JAS açısından şüphe edilmesini vurgulamak üzere sunuldu.
🔖
Cite This Article
ÖZALP, D., YILMAZ, Ö., SÖĞÜT, A., YÜKSEL, H. (2010). A Case of Juvenile Ankylosing Spondylitis associated with Familial Mediterranean Fever. Dicle Tıp Dergisi, Cilt: 37 - Sayı: 4, 397–400. https://ajindex.com/articles/349222
Ben-Chetrit E, Levy M. Familial Mediterranean Fever. Lancet 1998; 351: 659-64
Aksentiyevich I, Pras E, Gruberg L, Shen Y. Sutherland G. Refined mapping of the gene causing familial Mediterranean fever. by linkage and homozygosity studies. Am Hum Genet 1993; 53: 451-61
Mor A, Gal R, Livneh A. Abdominal and digestive system associations of familial Mediterranean fever. Am J Gastroenterol 2003; 98: 2594-604 4. Calin A. Ankylosing spondylitis. In: Maddison PJ, Isenberg PA, Woo P, Glass DN (eds). Oxford Textbook of Rheumatology. Oxford: Oxford University Press 1998; 1058-70
Tunca M, Akar S, Onen F, et al. Familial Mediterranean fever (FMF) in Turkey: Results of a nationwide multicenter study. Medicine (Baltimore) 2005; 84: 1-11
Kasapçopur O, Demirli N, Ozdoğan H, et al. Evaluation of classification criteria for juvenile-onset spondyloarthropathies. Rheumatol Int 2005; 25: 414-8
Kaşifoğlu T, Calişir C, Cansu DU, at al. The frequency of sacroiliitis in familial Mediterranean fever and the role of HLA-B27 and MEFV mutations in the development of sacroiliitis. Clin Rheumatol 2009; 28: 41-6 8. Dougados M, Gueguen A, Nakache JP, et al. Clinical relevance of C-reactive protein in axial involvement of ankylosing spondylitis. J Rheumatol 1999; 26: 971-4
Brodey PA, Wolff SM. Radiographic changes in the sacroiliac joints in familial Mediterranean fever. Radiology 1975; 114: 331-3
Langevitz P, Livneh A, Zemer D, Shemer J, Pras M. Seronegative spondyloarthropathy in familial Mediterranean fever. Semin Arthritis Rheum. 1997; 27: 67-72.