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Journals / Dicle Tıp Dergisi / 2012 / Cilt: 39 - Sayı: 1

A three years retrospective analysis of agents isolated from cerebrospinal fluid in a University Hospital

Bir üniversite hastanesi laboratuvarında beyin omurilik sıvısı'nda izole edilen mikroorganizmaların üç yıllık geriye dönük analizi

YÜCEL DUMAN
YUSUF YAKUPOĞULLARI
MEHMET SAİT TEKEREKOĞLU
Nilay GÜÇLÜER
Barış OTLU
Pages
70–74
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Results: 11 Streptococcus pneumoniae, 8 Klebsiella pneumoniae, 7 Pseudomonas aeruginosa, 7 Acinetobacter baumannii, 5 Escherichia coli, 4 Enterococcus spp., 2 Enterobacter spp., 25 Coagulase-negative staphylococcus, 1 Morganella morganii, 2 Neisseria meningitidis, 1 Brucella spp., and 1 Candida albicans were isolated (overall n:74; 5.2%) from total 1408 CSF samples.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: In this study, we aimed to investigate the agents which were isolated from cerebrospinal fluid (CSF) samples in our hospital for three years, retrospectively.
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Key Findings & Data:Materials and methods: The CSF samples, which were sent our laboratory, of the patients those had presumptive diagnosis of meningitis between September 2008 and September 2011 were included into the study.
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Conclusion & Impact:Results: 11 Streptococcus pneumoniae, 8 Klebsiella pneumoniae, 7 Pseudomonas aeruginosa, 7 Acinetobacter baumannii, 5 Escherichia coli, 4 Enterococcus spp., 2 Enterobacter spp., 25 Coagulase-negative staphylococcus, 1 Morganella morganii, 2 Neisseria meningitidis, 1 Brucella spp., and 1 Candida albicans were isolated (overall n:74; 5.2%) from total 1408 CSF samples.
🔬Design:Research Article
📍Scope:2008 Verileri
⚙️Variables:Domain Parameters

Abstract

Objectives: In this study, we aimed to investigate the agents which were isolated from cerebrospinal fluid (CSF) samples in our hospital for three years, retrospectively. Materials and methods: The CSF samples, which were sent our laboratory, of the patients those had presumptive diagnosis of meningitis between September 2008 and September 2011 were included into the study. Isolated bacteria were identified with conventional methods, biochemical tests and/or Phonix (BD, US) kits. Antimicrobial susceptibility of the strains were investigated according to Clinical Laboratory Standards Institute (CLSI) recommendations. Results: 11 Streptococcus pneumoniae, 8 Klebsiella pneumoniae, 7 Pseudomonas aeruginosa, 7 Acinetobacter baumannii, 5 Escherichia coli, 4 Enterococcus spp., 2 Enterobacter spp., 25 Coagulase-negative staphylococcus, 1 Morganella morganii, 2 Neisseria meningitidis, 1 Brucella spp., and 1 Candida albicans were isolated (overall n:74; 5.2%) from total 1408 CSF samples. In susceptibility test, 2 S.pneumonia was found as penicillin-resistant, and one E.coli and two K.pneumoniae were found as extended spectrum of beta-lactamase producers. Additionally, carbapenem resistance was detected in three A.baumannii and one P.aeruginosa strains. Conclusion: Determination of agent profile and antimicrobial resistance pattern from different localizations and patients’ groups will help to improve protective and therapeutic health policies.

Özet

Amaç: Bu çalışmada, hastanemizde üç yıllık dönemde beyin omurilik sıvısından (BOS) izole edilen ajanların geriye dönük analizi yapıldı. Gereç ve yöntem: Eylül 2008 ile Eylül 2011 yılları arasında laboratuvarımıza BOS örneği gönderilmiş olan hastaların sonuçları retrospektif olarak incelendi. Soyutlanan bakteri türleri konvansiyonel yöntemler, biyokimyasal testler ve/veya Phonix (BD, US) ticari identifikasyon sistemleri kullanılarak tanımlandı. Elde edilen türlerin antimikrobiyal duyarlılık testleri Clinical Laboratory Standards Institute (CLSI) önerileri doğrultusunda çalışıldı. Bulgular: Toplam 1408 hastaya ait BOS örneğinden 11 Streptococcus pneumoniae, 8 Klebsiella pneumoniae, 7 Pseudomonas aeruginosa, 7 Acinetobacter baumannii, 5 Escherichia coli, 4 Enterococcus spp., 2 Enterobacter spp., 25 koagülaz negatif stafilokok, 1 Morganella morganii, 2 Neisseria meningitidis, 1 Brucella spp., ve 1 Candida albicans olmak üzere toplam 74 (%5.2) üreme saptandı. Yapılan antibiyotik duyarlılık testinde 2 S.pneumoniae suşunda penisilin direnci saptanırken; bir E.coli ve iki K.pneumoniae suşunda genişlemiş spektrumlu beta-laktamaz (GSBL); üç acinetobacter ve bir pseudomonas suşunda ise karbapenem direnci saptandı. Sonuç: Farklı bölgelerde ve hasta topluluklarında etken ve antimikrobiyal direnç epidemiyolojisinin belirlenmesi koruyucu ve tedavi edici sağlık politikaların yapılandırılmasında faydalı olacaktır.

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Cite This Article

DUMAN, Y., YAKUPOĞULLARI, Y., TEKEREKOĞLU, M. S., GÜÇLÜER, N., OTLU, B. (2012). A three years retrospective analysis of agents isolated from cerebrospinal fluid in a University Hospital. Dicle Tıp Dergisi, Cilt: 39 - Sayı: 1, 70–74. https://ajindex.com/articles/349114

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