Journals / Dicle Tıp Dergisi / 2014 / Cilt: 41 - Sayı: 2

The effect of serum 25(OH) vitamin D on hemogram parameters

Serum 25(OH) D vitamini düzeyinin hemogram parametreleri üzerine etkisi

Pages
332–336
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin.
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Key Findings & Data:Methods: This retrospective study was done with the data obtained from 243 female and 59, totally 302 patients.
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Conclusion & Impact:These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Vitamin D that has pleiotropic hormone characteristics is a fat soluble vitamin. In general, vitamin D is known to be associated with rickets, but the studies show that vitamin D also acts on tissues and cells other than bone itself. In this study, we aimed to investigate if vitamin D has any effects on hemogram parameters or not. Methods: This retrospective study was done with the data obtained from 243 female and 59, totally 302 patients. Vitamin D level and hemogram parameters [(red blood cell (RBC), hemoglobin (Hb), white blood cell (WBC), platelet (PLT), mean platelet volume (MPV), and red cell distribution width (RDW)] of patients were obtained. Patients were divided into 4 groups according to their levels of vitamin D: Group 1: < 10 ng/mL; Group 2: 10-19 ng/mL; Group 3: 20-29 ng/mL, and Group 4: 30-60 ng/mL. Results: There were no significant differences in RBC, Hb, WBC, PLT, MPV, and RDW between the groups (p>0.05). Also, there was no correlation between the hemogram parameters and vitamin D. Conclusion: According to the literature, there are a lot of studies that show the relationship between vitamin D and WBC, RBC, and PLT. However, contrary to the previous studies, we were unable to find any significant relationship between vitamin D and hemogram parameters. These results serve the idea that the effects of vitamin D on the hematopoietic system should be further investigated experimentally and clinically.

Özet

Amaç: D vitamini pleitropik hormon özellikleri olan yağda çözünen bir vitamindir. Genel anlamda rikets ile beraber anılır ancak yapılan araştırmalar D vitamininin kemik dışı dokularda da etkin olduğunu göstermektedir. Biz de bu çalışmada serum D vitamini düzeyinin hemogram parametrelerine etkisi olup olmadığını araştırmayı amaçladık. Yöntemler: Bu retrospektif çalışma, 243 kadın 59 erkek toplam 302 hastanın verileri değerlendirilerek gerçekleş- tirildi. Hastaların D vitamini düzeyi ve hemogram [eritrosit sayısı (RBC), hemoglobin (Hb), beyaz küre sayısı (WBC), trombosit sayısı (PLT), ortalama trombosit volümü (MPV) ve eritrosit dağılım genişliği (RDW)] parametreleri elde edildi. Hastalar D vitamini düzeylerine göre 4 gruba ayrıldı: Grup 1: 0.05). Ayrıca, D vitamini ile hemogram parametreleri arasında herhangi bir korelasyon tespit edilmedi. Sonuçlar: Literatüre bakıldığında D vitamini ile WBC, RBC ve PLT arasında ilişki olduğunu gösteren çok sayıda yayın bulunmaktadır. Ancak, bizim çalışmamızda literatürün aksine D vitamini ile hemogram parametreleri arasında herhangi bir ilişki tespit edilemedi. Bu sonuçlar D vitamininin hematopoietik sistem üzerindeki etkilerinin deneysel ve klinik olarak daha iyi araştırılması gerektiği fikrini vermektedir.

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Cite This Article

ÖZTÜRK, G., BULUT, E., AKYOL, S., YAVUZ, M. T., GİNİŞ, Z., UÇAR, F., ERDEN, G. (2014). The effect of serum 25(OH) vitamin D on hemogram parameters. Dicle Tıp Dergisi, Cilt: 41 - Sayı: 2, 332–336. https://ajindex.com/articles/348885

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References (16)

  1. Lips P. Vitamin D physiology. Prog Biophys Mol Biol 2006;92:4-8
  2. Bogunia-Kubik K, Middleton P, Norden J, et al. Association of vitamin D receptor polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Int J Immunogenet 2008;35:207-213
  3. Provvedini DM, Tsoukas CD, Deftos LJ, et al. 1,25-dihydroxyvitamin D3 receptors in human leukocytes. Science 1983;221:1181-1183
  4. Baeke F, Gysemans C, Korf H, et al. Vitamin D insufficiency: implications for the immune system. Pediatr Nephrol 2010;25:1597-1606
  5. Yilmaz M, Yilmaz N. D vitaminin beyindeki rolü ve ilişkili nörolojik hastalıklar. J Clin Exp Invest 2013; 4:411-415
  6. Çidem M, Kara S, Sarı H, et al. Yaygın kas-iskelet ağrısı olan hastalarda D vitamini eksikliği prevalansı ve risk faktörleri. J Clin Exp Invest 2013; 4:488-491
  7. Köse N. Fibromiyalji hastalarında kan vitamin D düzeyleri ve D vitamini tedavisinin etkinliği. Dicle Med J 2013; 40:583-588
  8. Wallis DE, Penckofer S, Sizemore GW. The “sunshine deficit” and cardiovascular disease. Circulation 2008;118:1476- 1485
  9. Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr 2005;94:483-492
  10. Kıdır V. D vitamininin kardiyovasküler ve metabolik etkileri. J Clin Exp Invest 2013; 4:398-404
  11. Martins D, Wolf M, Pan D, et al. Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 2007;167:1159-1165. 12. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomized, placebo-controlled trial. Br J Nutr 2010;103:549-555
  12. Bunce CM, Brown G, Hewison M. Vitamin D and hematopoiesis. Trends Endocrinol Metab 1997;8:245-251
  13. Grande A, Montanari M, Tagliafico E, et al. Physiological levels of 1alpha, 25 dihydroxyvitamin D3 induce the monocytic commitment of CD34+ hematopoietic progenitors. J Leukoc Biol 2002;71:641-651
  14. Stach K, Kalsch AI, Nguyen XD, et al. 1alpha,25-dihydroxyvitamin D3 attenuates platelet activation and the expression of VCAM-1 and MT1-MMP in human endothelial cells. Cardiology. 2011;118:107-115
  15. Muller K, Diamant M, Bendtzen K. Inhibition of production and function of interleukin-6 by 1,25-dihydroxyvitamin D3. Immunol Lett 1991;28:115-120
  16. Canto