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Journals / Records of Natural Products / 2021 / Cilt: 15 - Sayı: 6

Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites

Zeynep FİRAT
Fatih DEMİRCİ
Betül DEMİRCİ
Hasan KIRMIZIBEKMEZ
Hüsnü Can BAŞER
Pages
593–601
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The antioxidant activity of the metabolites was found to be more effective in scavenging free radicals.

📌 3 Key Takeaways

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Objective & Hypothesis:Bisabolol is one of the bioactive constituents of chamomile.
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Key Findings & Data:Additionally, the biotransformation by Penicillium neocrassum yielded a new metabolite, which was characterized as 2-(5-methyl-5-(6-methyl-7-oxabicyclo[4.1.0]heptan-3- yl)tetrahydrofuran-2-yl)propan-2-ol = bisafuranol.
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Conclusion & Impact:The antioxidant activity of the metabolites was found to be more effective in scavenging free radicals.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Bisabolol is one of the bioactive constituents of chamomile. It was aimed to biotransform (–)-α- bisabolol by different fungi for the production of new bioactive metabolites, which was converted to α-bisabolol oxide A and B by Thamnidium elegans. Additionally, the biotransformation by Penicillium neocrassum yielded a new metabolite, which was characterized as 2-(5-methyl-5-(6-methyl-7-oxabicyclo[4.1.0]heptan-3- yl)tetrahydrofuran-2-yl)propan-2-ol = bisafuranol. The substrate and its metabolite mixtures were tested using antioxidant DPPH• scavenging assay. Antimicrobial activity was evaluated by an in vitro microdilution assay against a panel of human pathogenic bacteria and yeasts resulting in the lowest MIC and MFC values of 150 μg/mL. (–)-α-Bisabolol was effective against Propionibacterium acnes and Staphylococcus epidermidis (75, 37.5 μg/mL, respectively). The antioxidant activity of the metabolites was found to be more effective in scavenging free radicals.

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Cite This Article

FİRAT, Z., DEMİRCİ, F., DEMİRCİ, B., KIRMIZIBEKMEZ, H., BAŞER, H. C. (2021). Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites. Records of Natural Products, Cilt: 15 - Sayı: 6, 593–601. https://ajindex.com/articles/340389

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