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Journals / Records of Natural Products / 2020 / Cilt: 14 - Sayı: 2

Efficacy of Gynostemma pentaphyllum Extract in Anti-obesity Therapy

Yoon Hee KİM
So Mi KİM
Jae Kyoung LEE
Sung Kwan JO
Hyung Joong KİM
Kyu Min CHA
Cho Young LİM
Joo Myung MOON
Tae Young KİM
Eun Ji KİM
Pages
116–128
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results suggest the potential use of Gynostemma pentaphyllum in developing a therapeutic agent to reduce body weight and prevent diet-related diseases via glucose uptake and AMPK activation.

📌 3 Key Takeaways

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Objective & Hypothesis:In the present study, we investigated a saponin-enriched fraction from Gynostemma pentaphyllumextract (GPE) and isolated gypenoside L (GL), gypenoside LI (GLI), and ginsenoside Rg3 (Rg3).
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Key Findings & Data:To explore the anti-obesity activities of these compounds, we investigated the effects of GL, GLI, and Rg3 on glucose uptake and activation of AMPK in L6 skeletal muscle cells.
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Conclusion & Impact:Our results suggest the potential use of Gynostemma pentaphyllum in developing a therapeutic agent to reduce body weight and prevent diet-related diseases via glucose uptake and AMPK activation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

In the present study, we investigated a saponin-enriched fraction from Gynostemma pentaphyllumextract (GPE) and isolated gypenoside L (GL), gypenoside LI (GLI), and ginsenoside Rg3 (Rg3). To explore the anti-obesity activities of these compounds, we investigated the effects of GL, GLI, and Rg3 on glucose uptake and activation of AMPK in L6 skeletal muscle cells. GPE, GL, GLI, and Rg3 markedly increased glucose uptakeactivity and GLUT4 gene expression in L6 myotubes. The enhanced glucose uptake was mediated by the activation of the AMPK-ACC signaling pathway. In addition, we observed that GPE, GL, GLI, and Rg3 increased the expression of SIRT1 and PPARγ coacvtivator-1α (PGC-1α). Our results suggest the potential use of Gynostemma pentaphyllum in developing a therapeutic agent to reduce body weight and prevent diet-related diseases via glucose uptake and AMPK activation.

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Cite This Article

KİM, Y. H., KİM, S. M., LEE, J. K., JO, S. K., KİM, H. J., CHA, K. M., LİM, C. Y., MOON, J. M., KİM, T. Y., KİM, E. J. (2020). Efficacy of Gynostemma pentaphyllum Extract in Anti-obesity Therapy. Records of Natural Products, Cilt: 14 - Sayı: 2, 116–128. https://ajindex.com/articles/340374

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References (14)

  1. B. Viollet and F. Andreelli (2011). AMP-activated protein kinase and metabolic control, Handb. Exp. Pharmacol. 203, 303-330
  2. Y.K. Park, J. Lee, V.S. Hong, J.S. Choi, T.Y. Lee and B.C. Jang (2014). Identification of KMU-3, a novel derivative of gallic acid, as an inhibitor of adipogenesis, PLoS One 9, e109344
  3. J.H. Lee, M.H. Moon, J.K. Jeong, Y.G. Park, Y.J. Lee, J.W. Seol and S.Y. Park (2012). Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway, Biochem. Biophys. Res. Commun. 426, 492-497
  4. J.T. Hwang, M.S. Lee, H.J. Kim, M.J. Sung, H.Y. Kim, M.S. Kim and D.Y. Kwon (2009). Antiobesity effect of ginsenoside Rg3 involves the AMPK and PPAR-gamma signal pathways, Phytother. Res. 23, 262-266
  5. F. Soldati and O. Tanaka (1984). Panax ginseng: Relation between age of plant and content of ginsenosides, Planta Med. 50, 351-352
  6. J. Wang, T.K.Q. Ha, Y.P. Shi, W.K. Oh and J.L. Yang (2018). Hypoglycemic triterpenes from Gynostemma pentaphyllum, Phytochemistry 155, 171-181
  7. Y. Jin, Y.J. Kim, J.N. Jeon, C. Wang, J.W. Min, H.Y. Noh and D.C. Yang (2015). Effect of white, red and black ginseng on physicochemical properties and ginsenosides, Plant Foods Hum. Nutr. 70, 141-145
  8. S.B. Lim (2017). Enhancement of biological activity of saponin-rich plants by subcritical water hydrolysis, Int. J. Clin. Nutr. Diet. 3, 117 (4 pages)
  9. L.Q. Cheng, J.R. Na, M.K. Kim, M.H. Bang and D.C. Yang (2007). Microbial conversion of ginsenoside Rb1 to minor ginsenoside F2 and gypenoside XVII by Intrasporangium sp. GS603 isolated from soil, J. Microbiol. Biotechnol. 17, 1937-1943
  10. K.S. Kang, J. Ham, Y.J. Kim, J.H. Park, E.J. Cho and N. Yamabe (2013). Heat-processed Panax ginseng and diabetic renal damage: active components and action mechanism, J. Ginseng Res. 37, 379-388
  11. T.H. Huang, V. Razmovski-Naumovski, N.K. Salam, R.K. Duke, V.H. Tran, C.C. Duke and B.D. Roufogalis (2005). A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum, Biochem. Pharmacol. 70, 1298-1308
  12. L. Hu, Z. Chen and Y. Xie (1996). New triterpenoid saponins from Gynostemma pentaphyllum, J. Nat. Prod. 59, 1143-1145
  13. K.W. Lu, Y.S. Ma, F.S. Yu, Y.P. Huang, Y.L. Chu, R.S. Wu, C.L. Liao, F.S. Chueh and J.G. Chung (2017). Gypenosides induce cell death and alter gene expression in human oral cancer HSC-3 cells, Exp. Ther. Med. 14, 2469-2476
  14. W.C. Huang, M.L. Kuo, M.L. Li, R.C. Yang, C.J. L