Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034

Objective & Hypothesis:7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1).

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Key Findings & Data:Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses.

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Conclusion & Impact:The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.

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Cite This Article

AKSOY, S. Ç., KÜÇÜKSOLAK, M., UZEL, A., BEDİR, E. (2021). Benzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034. Records of Natural Products, Cilt: 15 - Sayı: 6, 602–607. https://ajindex.com/articles/340364

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References (1)

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