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Journals / Van Tıp Dergisi / 2013 / Cilt: 20 - Sayı: 3

Heme oxygenase products levels in stages of chronic obstructive pulmonary disease

Koah evrelerinde hemeürünlerinin düzeyleri oksijenaz enzimi son

HÜLYA GÜNBATAR
Nevra Güllü ARSLAN
Bünyamin SERTOĞULLARINDAN
SELAMİ EKİN
Pages
140–144
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies on this subject are necessary.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Heme oxygenase 1 is derived from alveolar macrophages and serves in the lung as a protective anti oxydant enzyme, reserves heme three antioxydant and anti-inflammatory final product; bilirubin, carbon monoxide and iron.
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Key Findings & Data:The aim of our study was to examine Heme oxygenase 1 enzyme latest products in Chronic Obstructive Pulmonary Disease patients according to stages.
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Conclusion & Impact:Further studies on this subject are necessary.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Heme oxygenase 1 is derived from alveolar macrophages and serves in the lung as a protective anti oxydant enzyme, reserves heme three antioxydant and anti-inflammatory final product; bilirubin, carbon monoxide and iron. The aim of our study was to examine Heme oxygenase 1 enzyme latest products in Chronic Obstructive Pulmonary Disease patients according to stages. Methods: The study included a total of 76 cases; 55 patients with Chronic Obstructive Pulmonary Disease and 21 volunteers older than 40 years old with normal lung function tests. Complete blood count, total bilirubin and serum iron levels were determined. Spirometric tests included forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and FEV1/FVC rate. Patients were classified as mild, moderate, severe and very severe according to Postbronchodilator FEV1 values. Results: The control and study groups displayed no statistically significant differences in terms of bilirubin and iron levels, and iron binding capacity. Bilirubin levels were increased with increasing stage of Chronic Obstructive Pulmonary Disease among themselves, no statistically significant difference was detected. Iron levels were significantly decreased while the stage of Chronic Obstructive Pulmonary Disease increased. Conclusion: Increased Chronic Obstructive Pulmonary Disease stage with decreasing iron levels could point to decreasing Heme oxygenase 1 enzyme levels. Further studies on this subject are necessary.

Özet

Amaç: Heme oksijenaz 1; Tip-2 pnömosit ve alveoaler makrofajlardan salınan, akciğerde koruyucu görev yapan bir antioksidan enzimdir, Heme’i antioksidan ve antiinflamatuar özellikleri olan 3 farklı son ürüne; bilirubin, karbon monoksit ve demire indirger. Çalışmamız; Heme oksijenaz 1 enziminin son ürünlerinin Kronik Obstruktif Akciğer Hastalığı hastalarında evrelere göre değişimini incelemek amacı ile yapıldı. Yöntem: Çalışmaya Kronik Obstruktif Akciğer Hastalığı tanılı 55 hasta ve solunum fonksiyon testi normal olan 40 yaş üstü 21 gönüllü kişiden oluşan toplam 76 olgu dahil edildi. Hemogram, Total bilirubin ve serum demir düzeyleri merkez biyokimya laboratuarı’nda çalışıldı. Spirometrik testler; zorlu vital kapasite (FVC), 1. saniyedeki zorlu ekspiratuar volüm (FEV1) veFEV 1/FVC oranını içerdi. Postbronkodilatör FEV1 değerlerine göre hastalar hafif, orta, ağır, çok ağır olarak sınıflandırıldı. Bulgular: Kontrol ve Çalışma grupları arasında bilirubin, demir, demir bağlama kapasitesi düzeyleri yönünden istatistiksel olarak anlamlı farklılık saptanmadı. Kronik Obstruktif Akciğer Hastalığı evresi arttıkça bilirübin düzeyleri kendi aralarında artmış tespit edildi, istatistiksel anlamlı fark tespit edilmedi. Kronik Obstruktif Akciğer Hastalığı evresi arttıkça demir düzeyi istatistiksel olarak anlamlı azalmıştı. Sonuç: Kronik Obstruktif Akciğer Hastalığı evresi ağırlaştıkça demir düzeyinin düşmesi Heme oksijenaz 1 enziminde azalmaya işaret edebilir. Bu konuda ileri çalışmaların yapılmasına gerek vardır.

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Cite This Article

GÜNBATAR, H., ARSLAN, N. G., SERTOĞULLARINDAN, B., EKİN, S. (2013). Heme oxygenase products levels in stages of chronic obstructive pulmonary disease. Van Tıp Dergisi, Cilt: 20 - Sayı: 3, 140–144. https://ajindex.com/articles/334184

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