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Journals / Viral Hepatitis Journal / 2017 / Cilt: 23 - Sayı: 2

TNF-alfa 308 SNP Rs3091256 GG Genotipi Hepatit C Virüs Hastalarının Karaciğer Fibrozis Evreleri ile İlişkilidir

TNF-alpha 308 SNP Rs3091256 GG Genotype is Strongly Associated with Fibrosis in Patients with Chronic Hepatitis C

ÖZGÜR GÜNAL
Didem YALÇIN
Betül ÇELİK
Aydın RÜSTEMOĞLU
OSMAN DEMİR
Şener BARUT
HACI ÖMER ATEŞ
SÜLEYMAN SIRRI KILIÇ
Pages
39–45
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Materials and Methods: Ninety-five patients with chronic hepatitis C virus (HCV) infection and 97 controls were enrolled.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: We aimed to review the influence of host genetic factors on the clinical course, treatment response as well as fibrosis progression in patients with viral hepatitis C genotype 1.
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Key Findings & Data:Objective: We aimed to review the influence of host genetic factors on the clinical course, treatment response as well as fibrosis progression in patients with viral hepatitis C genotype 1.
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Conclusion & Impact:Materials and Methods: Ninety-five patients with chronic hepatitis C virus (HCV) infection and 97 controls were enrolled.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to review the influence of host genetic factors on the clinical course, treatment response as well as fibrosis progression in patients with viral hepatitis C genotype 1. Materials and Methods: Ninety-five patients with chronic hepatitis C virus (HCV) infection and 97 controls were enrolled. The patients

Özet

Amaç: Viral hepatit C genotip 1 hastalarında genetik faktörlerin klinik gidiş, tedavi cevabı ve fibrozis ilerlemesi üzerindeki etkisini gözden geçirmektir.Gereç ve Yöntemler: Çalışmaya 95 kronik hepatit C virüs (HCV) hastası ve 97 sağlıklı gönüllü dahil edildi. Hastalar 48 hafta süreyle pegylated interferon (Peg-IFN)+ribavirin tedavisi kullandı ve sonraki 48 hafta boyunca takip edildi. Karaciğer fibrozis evresini belirlemek için aspartat aminotransferaz/platelet ratio (APRI) kullanıldı. DNA örnekleri periferik kan mononükleer hücrelerden izole edildi ve tümör nekroz faktörü-alfa (TNF-?) 308 rs3091256, polimeraz zincir reaksiyonu-kısıtlama fragmanı uzunluğu polimorfizmi yöntemi ile genotiplendi.Bulgular: Tüm hastalar HCV genotip 1 ile enfekte idi. HCV hastalarının (95), %25,5 spontan viral klirensi, %44,2'si hızlı viral yanıt, %91,8'i erken viral yanıt ve %73,3'ünde kalıcı viral yanıt gözlendi. Hastalar ve kontroller arasında allel ve genotip açısından anlamlı fark yoktu. Virolojik yanıt da belirgin değildi. Bununla birlikte, TNF-?-308 tek nükleotit polimorfizmi (SNP) rs3091256 GG genotipi fibroz ve alanin aminotransferaz (ALT) seviyeleri ile kuvvetli bir şekilde ilişkiliydi (sırasıyla p=0,006 ve p=0,017).Sonuç: TNF-?-308 polimorfizmleri, ülkeler arasında farklı sonuçlar ortaya çıkarabilir. SNP rs3091256 GG'ye sahip hastalar, daha yüksek ALT ve fibroz skoru göstermekle birlikte, bu popülasyonda daha iyi tedavi sonucuna sahiptir

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Cite This Article

GÜNAL, Ö., YALÇIN, D., ÇELİK, B., RÜSTEMOĞLU, A., DEMİR, O., BARUT, Ş., ATEŞ, H. Ö., KILIÇ, S. S. (2017). TNF-alfa 308 SNP Rs3091256 GG Genotipi Hepatit C Virüs Hastalarının Karaciğer Fibrozis Evreleri ile İlişkilidir. Viral Hepatitis Journal, Cilt: 23 - Sayı: 2, 39–45. https://ajindex.com/articles/331935

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