SavedAdd your journal

Journals / Ortadoğu Tıp Dergisi / 2015 / Cilt: 7 Sayı: 4

The investigation of the relationship between serum advanced oxidation protein product AOPP levels and laboratory findings in patients with chronic hepatitis B

Kronik Hepatit B’li Hastalarda Serum İleri Oksidasyon Protein Ürünleri AOPP Düzeyi İle Laboratuvar Bulguları Arasındaki İlişkinin Araştırılması

Aydın Çifci(Kırıkkale University Faculty of Medicine, Department of Internal Medicine)
H Şener Barut(Gaziosmanoaşa University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology)
Salih Cesur(Ankara Training and Research Hospital, Clinic of Infectious Diseases and Clinical Microbiology)
Özgür Günal(Gaziosmanoaşa University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology)
Yasemin Fidan(Ankara Training and Research Hospital, Clinic of Biochemistry and Clinical Biochemistry)
Selim Yalçın(Kırıkkale University Faculty of Medicine, Department of Internal Medicine, Division of Medical Oncology)
Meral Saygun(Kırıkkale University Faculty of Medicine, Department of Public Health)
Pages
167–171
Publication Date
2015-12-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

AST, ALT, and HBV DNA levels, platelet counts, Knodell histological activity index, and fibrosis scores of the patients were determined.Results: There was no statistically significant difference between the patients with CHB infection and the control group in terms of gender, age, ALT, AST, HBV DNA, Knodell activity index, fibrosis score, platelet count and serum AOPP levels 81.42 ± 32.0 micro M/mL and 73.2 ± 21.8 micro M/mL P = 0.38 , Conclusion: Although no significant association was found between serum AOPP levels and liver transaminases, viral load, liver histologic activity index, fibrosis score, and platelet count, the authors consider that further comprehensive studies are required to determine the importance of serum AOPP levels in patients with CHB infection

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: The aim of the present study was to evaluate the relationship between advanced oxidation protein products AOPP , AST, ALT, HBV DNA levels, Knodell histologic activity index, fibrosis score, and platelet counts in patients with chronic hepatitis B CHB infection.
📊
Key Findings & Data:Material and Methods: The study included 25 patients and 20 healthy controls.
💡
Conclusion & Impact:AST, ALT, and HBV DNA levels, platelet counts, Knodell histological activity index, and fibrosis scores of the patients were determined.Results: There was no statistically significant difference between the patients with CHB infection and the control group in terms of gender, age, ALT, AST, HBV DNA, Knodell activity index, fibrosis score, platelet count and serum AOPP levels 81.42 ± 32.0 micro M/mL and 73.2 ± 21.8 micro M/mL P = 0.38 , Conclusion: Although no significant association was found between serum AOPP levels and liver transaminases, viral load, liver histologic activity index, fibrosis score, and platelet count, the authors consider that further comprehensive studies are required to determine the importance of serum AOPP levels in patients with CHB infection
🔬Design:Makale
📍Scope:Comprehensive Sample
⚙️Variables:Kronik hepatit B · ileri oksidasyon protein ürünleri AOPP · klinik bulgular

Abstract

Aim: The aim of the present study was to evaluate the relationship between advanced oxidation protein products AOPP , AST, ALT, HBV DNA levels, Knodell histologic activity index, fibrosis score, and platelet counts in patients with chronic hepatitis B CHB infection. Material and Methods: The study included 25 patients and 20 healthy controls. Serum AOPP levels were analyzed with the spectrophotometric method using an ELISA kit. AST, ALT, and HBV DNA levels, platelet counts, Knodell histological activity index, and fibrosis scores of the patients were determined.Results: There was no statistically significant difference between the patients with CHB infection and the control group in terms of gender, age, ALT, AST, HBV DNA, Knodell activity index, fibrosis score, platelet count and serum AOPP levels 81.42 ± 32.0 micro M/mL and 73.2 ± 21.8 micro M/mL P = 0.38 , Conclusion: Although no significant association was found between serum AOPP levels and liver transaminases, viral load, liver histologic activity index, fibrosis score, and platelet count, the authors consider that further comprehensive studies are required to determine the importance of serum AOPP levels in patients with CHB infection

Özet

Amaç: Bu çalışmanın amacı, kronik hepatit B KHB infeksiyonu olan hastalarda serum ileri oksidasyon protein ürünleri AOPP düzeyleri ile karaciğer transaminazları olarak bilinen alanin aminotransferaz ALT , aspartat aminotransferaz AST düzeyleri, viral yük HBV-DNA düzeyi , karaciğer histolojik aktivite indeksi Knodell aktivite indeksi , fibrozis skoru ve trombosit sayıları arasındaki ilişkinin araştırılmasıdır. Yöntem ve Gereçler: Çalışmaya tedavi öncesi olan 25 KHB hastası ve 20 sağlıklı kontrol grubu dahil edildi. Hasta ve kontrol grubunun serum AOPP düzeyleri spektrofotometrik yöntemle ticari ELISA kiti kullanılarak belirlendi. Hastaların AST, ALT, HBV-DNA düzeyleri, trombosit sayıları ile karaciğer biyopsisini kabul eden ve biyopsi yapılan hastalarda Knodell histolojik aktivite indeksi, fibrozis skoru belirlendi. Bulgular: Kronik hepatit B hastaları ile sağlıklı kontrol grubu arasında cinsiyet ve yaş ortalaması açısından anlamlı farklılık saptanmadı. KHB hastalarında serum AOPP düzeyleri ile karaciğer transaminazları ALT, AST , düzeyleri, viral yük HBV-DNA düzeyi , karaciğer histolojik aktivite indeksi Knodell aktivite indeksi , fibrozis skoru ve trombosit sayıları arasında istatistiksel olarak anlamlı ilişki saptanmadı.Kronik hepatit B hastaları ile kontrol grubunun serum AOPP düzeyleri sırasıyla; 81.4 ± 32 mikro M/mL ve 73.2 ± 21 mikro M/mL arasında istatistiksel olarak anlamlı farklılık yoktu.Sonuç: Çalışmamızda serum AOPP düzeyleri ile karaciğer transaminazları, viral yük, karaciğer histolojik aktivite indeksi, fibrozis skoru ve trombosit sayısı arasında istatistiksel olarak anlamlı ilişki saptanmadı. Yeni oksidatif stres göstergesi olan serum AOPP düzeylerinin KHB’li hastalarda öneminin belirlenmesi için daha fazla örneklem sayılı kontrollü çalışmalara gereksinim olduğu görüşündeyiz

🔖

Cite This Article

Çifci, A., Barut, H. Ş., Cesur, S., Günal, Ö., Fidan, Y., Yalçın, S., Saygun, M. (2015). The investigation of the relationship between serum advanced oxidation protein product AOPP levels and laboratory findings in patients with chronic hepatitis B. Ortadoğu Tıp Dergisi, Cilt: 7 Sayı: 4, 167–171. https://ajindex.com/articles/1092873

References (15)

  1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment and current and emerging prevention and control measures. J Viral Hepat 2004; 11: 97-107.
  2. Oğuz D. Kronik hepatit B tedavisinde başarıyı etkileyen faktörler. Güncel Gastroenteroloji Dergisi 2008; 12: 151 - 154 (Turkish).
  3. Fattovich G, Bortolotti F, Donato F. Natural history of hepatitis B: special emphasis on disease progression and prognostic factors. J Hepatol 2008; 48: 335-352.
  4. Türk Karaciğer Araştırmaları Derneği Ulusal Hepatit Sıklığı Çalışması (TÜRKHEP 2010) www.tasl.org.tr/dosya/tasl Ulusal Hepatit Sıklığı Çalışması. ‎ (Turkish)
  5. Tozun N, Ozdogan OC, Cakaloglu Y, et al. Nationwide prevalence study and risk factors for hepatitis A,B, C and D infections in Turkey. Hepatology, Vol 52, 697A, 2010.
  6. Fatma Sırmatel, Fazilet Duygu, Hakim Celik, et al. Kronik viral hepatit olgularında total oksidatif seviye ve total antioksidan kapasitenin değerlendirilmesi. Klimik Dergisi 2009; 22: 92–96 (Turkish).
  7. Ozenirler S, Erkan G, Gülbahar O, et al. Serum levels of advanced oxidation protein products, malonyldialdehyde, and total radical trapping antioxidant parameter in patients with chronic hepatitis C. Turk J Gastroenterol. 2011; 22: 47-53.
  8. Witko-Sarsat V, Friedlander M, Nguyen Khoa T, et al. Advanced oxidation protein products as novel mediators of inflammation and monocyte activation in chronic renal failure. J Immunol 1998; 161: 2524-2532.
  9. Liu H, Han T, Tian J, et al. Monitoring oxidative stress in acute- on-chronic liver failure by advanced oxidation protein products. Hepatol Res. 2012; 42: 171-180.
  10. OxiSelect™ AOPP Assay Kit katalogu. www.cellbiolabs.com / AOPP.‎
  11. Atik E, Onlen Y, Savas L, Doran F. Inducible nitric oxide synthase and histopathological correlation in chronic viral hepatitis. Int J Infect Dis. 2008; 12: 12-15.
  12. Özlem Kandemir, Gülçin Eskandari, Gülden Ersöz, Ali Kaya. Kronik viral hepatitli hastalarda total antioksidan kapasite. Flora 2002; 7: 49-52 (Turkish).
  13. Kalousova M, Skrha J, Zima T. Advanced glycation endproducts and advanced oxidation protein products in patients with diabetes mellitus. Physiol Res 2002; 51: 597–604.
  14. Sebekova K, Klenovicssova K, Ferenczova J, Hedvig J, Podracka L, Heidland A. Advanced oxidation protein products and advanced glycation end products in children and adolescents with chronic renal insufficiency. Journal of Nutrition, 2012; 22: 143-148.
  15. Furuya R, Kumagai H, Odamaki M, Takahashi M, Miyaki A, Hishida A. Impact of residual renal function on plasma levels of advanced oxidation protein products and pentosidine in peritoneal dialysis patients. Nephron Clin Pract. 2009; 112: 255-261.