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Journals / Ortadoğu Tıp Dergisi / 2016 / Cilt: 8 - Sayı: 3

Can the Red Cell Distribution Width be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?

Ailevi Akdeniz Ateşinde Eritrosit Dağılım Genişliği Kolşisin Direncinin Bir Belirleyicisi Olabilir mi?

Orhan KÜÇÜKŞAHİN
Ahmet OMMA
Sevinç Can SANDIKÇI
Mehmet Emin ENECİK
Yaşar KARAASLAN
Seda ÇOLAK
Pages
145–151
Publication Date
2022-11-05
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Correlation analysis showed a positive correlation between serum RDW levels and ESR value (r=0.28, p

📌 3 Key Takeaways

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Objective & Hypothesis:Aim:In this study we aimed to assess the clinical utility of the Red Cell Distribution Width (RDW) in predicting colchicine resistance in Familial Mediterranean Fever (FMF) patients.Material and Methods: 197 FMF and 111 healthy controls (HC) were enrolled to the study.
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Key Findings & Data:The associations between RDW and other known indicators of systemic inflammation [Mean Platelet Volüme (MPV), Neutrophil to Lymphocyte Ratio (NLR), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP)] and patient clinical characteristics were investigated.
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Conclusion & Impact:Correlation analysis showed a positive correlation between serum RDW levels and ESR value (r=0.28, p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim:In this study we aimed to assess the clinical utility of the Red Cell Distribution Width (RDW) in predicting colchicine resistance in Familial Mediterranean Fever (FMF) patients.Material and Methods: 197 FMF and 111 healthy controls (HC) were enrolled to the study. FMF patients were grouped into two according to FMF with attack, FMF with attack free period, colchicine resistance FMF (Cr-FMF), colchicine non resistance FMF (Cnr-FMF) and laboratory parameters were compared between them. The associations between RDW and other known indicators of systemic inflammation [Mean Platelet Volüme (MPV), Neutrophil to Lymphocyte Ratio (NLR), Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP)] and patient clinical characteristics were investigated. Results: ESR, CRP, NLR and RDW levels were found to be significantly higher in the FMF group than the control group [14 vs 7 , p < 0.001 for ESR, 8 vs 2 , p < 0.001 for CRP, 2.1 (0.7-27.2) vs 1.8 (0.8-6.8), p=0.03 for NLR, 14.5±1.9 vs13.4±1.0, p< 0.001 for RDW]. ESR, CRP, NLR and RDW were higher in the attack group than attack free group [31 vs 10 , p< 0.001 for ESR, 24 vs 5 , p < 0.001 for CRP, 2.8 (1.0-8.1) vs 2.0 (0.7-27.2), p=0.002 for NLR, 15.0±2.1vs 15.0±2.1, p= 0.04 for RDW]. ESR, CRP, RDW and NLR values were higher in Cr-FMF group than the Cnr- FMF group [32 vs 12 , p< 0.001 for ESR, 22.5 vs 6 , p< 0.001 for CRP, 15.5±2.2 vs 14.4±1.8, p= 0.004 for RDW, 2.6 (1.1-7.1) vs 2.0 (0.7-27.2), p= 0.02 for NLR]. Correlation analysis showed a positive correlation between serum RDW levels and ESR value (r=0.28, p

Özet

Amaç: Ailevi Akdeniz Ateşi hastalarında atak döneminde ve kolşisin direnci olan hastalarda eritrosit dağılım genişliğinin klinik kullanımını değerlendirmeyi amaçladık. Yöntem ve Gereçler: 197 FMF hastası ve 111 sağlıklı kontrol calışmaya alındı. FMF hastaları; atak ve atak dışı dönem, kolşisin direnci olanlar ve kolşisin direnci olmayanlar olarak gruplara ayrıldı. RDW, diğer bilinen sistemik inflamasyon belirteçleri (MPV, NLR, ESR, CRP) ve hastaların klinik özellikleri incelendi. Bulgular: ESR, CRP, NLR ve RDW seviyeleri FMF grubunda kontrol grubuna göre anlamlı olarak yüksek bulundu [ESR için 14 ve 7 , p < 0.001, CRP için 8 ve 2 , p < 0.001, NLR için 2.1 (0.7-27.2) ve 1.8 (0.8-6.8), p=0.03, RDW için 14.5±1.9 ve 13.4±1.0, p< 0.001]. FMF atağı olan hastalarda ataksız hastalara kıyasla ESR, CRP, NLR ve RDW değerleri anlamlı olarak yüksek saptandı [ESR için 31 ve 10 , p< 0.001, CRP için 24 ve 5 , p < 0.001, NLR için 2.8 (1.0-8.1) ve 2.0 (0.7-27.2), p=0.002, RDW için 15.0±2.1ve 15.0±2.1, p= 0.04]. Yine Cr-FMF hastalarında Cnr- FMF hastalara kıyasla ESR, CRP, RDW ve NLR anlamlı olarak yüksek saptandı [ESR için 32 ve 12 , p< 0.001, CRP için 22.5 ve 6 , p< 0.001, RDW için 15.5±2.2 ve 14.4±1.8, p= 0.004, NLR için 2.6 (1.1-7.1) ve 2.0 (0.7-27.2), p= 0.02 ]. Korelasyon analizleri serum RDW ile ESR değerleri arasında pozitif korelasyon olduğunu gösterdi (r=0.28, p

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Cite This Article

KÜÇÜKŞAHİN, O., OMMA, A., SANDIKÇI, S. C., ENECİK, M. E., KARAASLAN, Y., ÇOLAK, S. (2022). Can the Red Cell Distribution Width be a Predictor of Colchicine Resistance in Familial Mediterranean Fever?. Ortadoğu Tıp Dergisi, Cilt: 8 - Sayı: 3, 145–151. https://ajindex.com/articles/653567

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