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Journals / Türk Uyku Tıbbı Dergisi / 2019 / Cilt: 6 - Sayı: 1

Chronic Intermittent Hypoxemia in Patients with Obstuctive Sleep Apnea Syndrome Causes Reduction of Peripheral Nerve Motor Fibers (Unit Number)

Obstrüktif Uyku Apne Sendromunda Kronik İntermitant Hipoksemi Periferik Sinir Motor Liflerde (Ünit Sayısında) Azalmaya Neden Olur

Kezban ASLAN
Taylan PEKÖZ
GÜLŞAH SEYDAOĞLU
Hacer BOZDEMİR
Yakup SARICA
Pages
10–15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The MUNE method demonstrates that chronic intermittent hypoxemia during sleep causes reduction of the motor unit number in OSAS patients and is an independent risk factor for subclinical polyneuropathy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Obstructive Sleep Apnea syndrome (OSAS) is a chronic intermittent hypoxic process.
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Key Findings & Data:Materials and Methods: According to the apnea-hypopnea index (AHI), patients divided into two groups (group 1: AHI 0.5).
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Conclusion & Impact:Conclusion: The MUNE method demonstrates that chronic intermittent hypoxemia during sleep causes reduction of the motor unit number in OSAS patients and is an independent risk factor for subclinical polyneuropathy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Obstructive Sleep Apnea syndrome (OSAS) is a chronic intermittent hypoxic process. In this study, we aimed to investigate electrophysiologically the changes in number of skeletal muscle motor unit due to chronic intermittent hypoxemia in cases followed up with the diagnosis of OSAS. Materials and Methods: According to the apnea-hypopnea index (AHI), patients divided into two groups (group 1: AHI 0.5). Maximum M mean area of nerve medianus was 50.8±20.4 (16.1-121.7) in group 1 and 48.6±20.05 (10.5-111.4) in group 2 (p=0.55). The mean MUNE values were 155.3±41.17 (46.6- 251.7) in group 1 and 127.7±40.2 (22.8-235) in group 2 (p<0.00). Conclusion: The MUNE method demonstrates that chronic intermittent hypoxemia during sleep causes reduction of the motor unit number in OSAS patients and is an independent risk factor for subclinical polyneuropathy.

Özet

Amaç: Obstrüktif Uyku Apne sendromu (OSAS) kronik tekrarlayıcı hipoksik süreçtir. Bu çalışmada OSAS tanısı ile izlenen olgularda kronik hipoksinin iskelet kası motor ünit sayısında yaptığı değişiklikler araştırıldı. Gereç ve Yöntem: Apne-hipopne indeksine (AHİ) göre hastalar 2 gruba ayrıldılar [grup 1: AHİ 0,5). N. medianusa ait maksimum M alan ortalaması grup 1’de 50,8±20,4 (16,1-121,7), grup 2’de 48,6±20,05 (10,5-111,4) saptandı (p=0,55). MUNE ortalaması grup 1’de 155,3±41,17 (46,6-251,7) ve grup 2’de 127,7±40,2 (22,8-235) (p<0,00) olarak belirlendi. Sonuç: OSAS hastalarda, MUNE yöntemi ile motor ünit sayısında anlamlı düzeyde azalma, uyku sırasında tekrarlayan kronik hipokseminin OSAS hastalarında MUNE’de azalmaya ve subklinik polinöropati için bağımsız bir risk faktörü olduğunu göstermektedir.

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Cite This Article

ASLAN, K., PEKÖZ, T., SEYDAOĞLU, G., BOZDEMİR, H., SARICA, Y. (2019). Chronic Intermittent Hypoxemia in Patients with Obstuctive Sleep Apnea Syndrome Causes Reduction of Peripheral Nerve Motor Fibers (Unit Number). Türk Uyku Tıbbı Dergisi, Cilt: 6 - Sayı: 1, 10–15. https://ajindex.com/articles/327939

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