Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2010 / Cilt: 16 - Sayı: 6

Tavşanlarda deneysel abdominal kompartman sendromunun tanısında kobalt-albümin bağlanma analizinin rolü

The role of cobalt-albumin binding analysis in the diagnosis of experimental abdominal compartment syndrome in rabbits

Pages
491–496
DOI
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CONCLUSION CABA plays an important role in the early diagnosis of ACS at the beginning of intestinal ischemia.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND The purpose of our study was to examine the role of cobalt-albumin binding assay (CABA) for the early diagnosis of abdominal compartment syndrome (ACS).
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Key Findings & Data:METHODS Twenty-four anesthetized and ventilated rabbits were randomly assigned to four groups as 1 to 4, with each group comprised of six animals.
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Conclusion & Impact:CONCLUSION CABA plays an important role in the early diagnosis of ACS at the beginning of intestinal ischemia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND The purpose of our study was to examine the role of cobalt-albumin binding assay (CABA) for the early diagnosis of abdominal compartment syndrome (ACS). METHODS Twenty-four anesthetized and ventilated rabbits were randomly assigned to four groups as 1 to 4, with each group comprised of six animals. Intraabdominal hypertension of 25 mmHg was induced for 15, 30, 45, and 60 minutes by insufflation in the four groups, respectively. Five ml of blood was drawn from each animal before the animals were sacrificed. A CABA test was performed on the samples and results were compared with pathologic diagnosis of intestinal samples shown as a score of damage severity values. RESULTS Ischemia-modified albumin (IMA) in Group 4 was significantly higher than in Group 1 and Group 2 (0.65±0.16, 0.60±0.25 and 0.61±0.14, respectively; p<0.05). However, there was no significant difference between the IMA of Group 3 and Group 4. Score of damage severity values reached statistically significant levels in Group 4 compared with Group 1 and Group 2 (p<0.004 and 0.006, respectively) and in Group 3 compared with Group 1 (p<0.004). There was also a statistically significant difference between Groups 1 and 2 (p<0.004). CONCLUSION CABA plays an important role in the early diagnosis of ACS at the beginning of intestinal ischemia.

Özet

AMAÇ Çalışmanın amacı, abdominal kompartma sendromunun (AKS) erken tanısında kobalalbümin bağlanma testinin (KABT) rolünü incelemektir. GEREÇ VE YÖNTEM Her grupta altı hayvan olmak üzere, 24 anestezi uygulanmış ve ventile edilen tavşan rastgele dört gruba ayrıldı. 25 mmHg karın içi hipertansiyon gaz verme yoluyla, sırasıyla 15., 30., 45. ve 60. dakikalarda elde edildi. Hayvanlar öldürülmeden önce her birinden 5 mL kan örneği alındı. Örnekler üzerinde KABT testi uygulandı ve hasar şiddet skoru olarak gösterilen bağırsak örneklerinin patolojik tanıları ile karşılaştırıldı. BULGULAR Dördüncü gruptaki iskemi modifiye albümin (İMA) hem Grup 1 hem de Grup 2?den istatistiksel olarak daha büyük bulundu (sırasıyla 0,65±0,16, 0,60±0,25 ve 0,61±0,14) (p<0,05). Grup 3 ve Grup 4?ün İMA değerleri arasında istatistiksel bir fark bulunmadı. Grup 4, Grup 1 ve Grup 2 ile karşılaştırıldığında (sırasıyla p<0,004 and 0,006) ve Grup 3, Grup 1 ile karşılaştırıldığında hasar şiddet skoru istatistiksel olarak anlamlı bulundu (p<0,004). Grup 1 ve Grup 2 arasında da istatistiksel olarak anlamlı fark bulundu (p<0,004). SONUÇ AKS'nin erken tanısında iskeminin başlangıcında KABT önemli bir rol oynamaktadır.

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Cite This Article

ÜNLÜER, E. E., KILIÇ, T. Y., AKGÖL, E., İŞGÜVEN, D., VARDAR, E., BAYOL, Ü., YILMAZ, O., ERKAN, N., GÖKMEN, A. N. (2010). Tavşanlarda deneysel abdominal kompartman sendromunun tanısında kobalt-albümin bağlanma analizinin rolü. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 16 - Sayı: 6, 491–496. https://ajindex.com/articles/324557

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