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Journals / Ulusal Travma ve Acil Cerrahi Dergisi / 2017 / Cilt: 23 - Sayı: 5

Separate and synergistic effects of taurolidine and icodextrin in intra-abdominal adhesion prevention

HASAN FEHMİ KÜÇÜK
LEVENT KAPTANOĞLU
Hasan Ediz SIKAR
Necmi KURT
Pages
377–382
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Additional experimental studies are required for dose adjustment

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND: In our present study, we aimed to evaluate the effects of taurolidine, a blocking agent of fibrin deposition, and icodextrin, a colloid osmotic material that also inhibits fibrin accumulation, and the effect of their application separately and concomittantly in intra-abdominal adhesion prevention.METHODS: Forty BALB/c male mice, weighing 30–35 g and 11–12 weeks old were divided into four groups as follows: group 1: control group, group 2: taurolidine group, group 3: icodextrin group, and group 4: taurolidine and icodextrin group.
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Key Findings & Data:Animals were sacrificed by cervical dislocation after 14 days.
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Conclusion & Impact:Additional experimental studies are required for dose adjustment
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

BACKGROUND: In our present study, we aimed to evaluate the effects of taurolidine, a blocking agent of fibrin deposition, and icodextrin, a colloid osmotic material that also inhibits fibrin accumulation, and the effect of their application separately and concomittantly in intra-abdominal adhesion prevention.METHODS: Forty BALB/c male mice, weighing 30–35 g and 11–12 weeks old were divided into four groups as follows: group 1: control group, group 2: taurolidine group, group 3: icodextrin group, and group 4: taurolidine and icodextrin group. Animals were sacrificed by cervical dislocation after 14 days. The adhesions were classified and scored by two blinded researchers according to Nair’s macroscopic adhesion staging system and microscopically evaluated using Zuhlke classification system.RESULTS: In group 2 there was no mice with score 4. In group 3, scores 3 and 4 were absent. Scores 2, 3, and 4 were not detected in group 4. The mean value of adhesion scores decreased from groups 1 to 4. There was a significant statistical difference between all the groups and group 1. There was no change between the study groups on macroscopic examination, whereas histopathological examination revealed statistically significance between group 4 and other groups.CONCLUSION: Taurolidine and icodextrin, when used alone or together, decrease postoperative intra-abdominal adhesion formation. Macroscopic appearence was not supportive of statistical difference between group 4 and other groups. Microscopic evaluation paves the road for future studies for determining significance when taurolidine and icodextrin are applied concomittantly. Additional experimental studies are required for dose adjustment

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Cite This Article

KÜÇÜK, H. F., KAPTANOĞLU, L., SIKAR, H. E., KURT, N. (2017). Separate and synergistic effects of taurolidine and icodextrin in intra-abdominal adhesion prevention. Ulusal Travma ve Acil Cerrahi Dergisi, Cilt: 23 - Sayı: 5, 377–382. https://ajindex.com/articles/323989

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