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Journals / Uluslararası Hematoloji-Onkoloji Dergisi / 2009 / Cilt: 19 - Sayı: 4

The prognostic significance of the expression of insulin-like growth factor receptor-I in prostate cancer

Prostat kanserinde insülin benzeri büyüme faktörü-I reseptör ekspresyonunun prognostik önemi

Aylin.F. KORCUM
Elif TEKELİ
MELEK GAMZE AKSU
Gülgün ERDOĞAN
Akif ÇİFTÇİOĞLU
Pages
223–231
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The 4-year overall survival, biochemically freedom from relapse free and distant metastasis free survival were 76%, 80% and 93% respectively.

📌 3 Key Takeaways

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Objective & Hypothesis:We aimed to investigate the expression of IGF-IR in prostate cancer and to evaluate their prognostic significance.
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Key Findings & Data:Between 1999 and 2007, the expression of IGF-IR was investigated by using an immunohistochemical approach in fifty-nine prostate cancer patients who were treated with radiotherapy.
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Conclusion & Impact:The 4-year overall survival, biochemically freedom from relapse free and distant metastasis free survival were 76%, 80% and 93% respectively.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:İmmünohistokimya · Prostat neoplazmları · Neoplazm derecelendirmesi

Abstract

We aimed to investigate the expression of IGF-IR in prostate cancer and to evaluate their prognostic significance. Between 1999 and 2007, the expression of IGF-IR was investigated by using an immunohistochemical approach in fifty-nine prostate cancer patients who were treated with radiotherapy. Median age was 73 (ranged 56-83) years and median follow up was 48.3 months. Fourty-three patients (73%) were found be IGF-IR positive. Biochemically freedom from relapse free survival was significantly higher in patients with negative stained IGF-IR, age < 70, Gleason score < 8, PSA0 value &#8804; 20 ng/ml. Multivariate analysis demonstrated that PSA0 value &#8804; 20 ng/ml and PSA2 value &#8804;0.36 ng/ml were statistically significant predictors of biochemically freedom from relapse free survival. The 4-year overall survival, biochemically freedom from relapse free and distant metastasis free survival were 76%, 80% and 93% respectively. This study demostrated that presence of IGF-IR expression was significantly associated with beter biochemically freedom from relapse free survival rates.

Özet

Prostat kanserli hastalarda İnsulin Benzeri Büyüme Faktörü-I Reseptör (IGF-IR) ekspresyonu ve prognostik önemi araştırıldı.1999-2007 yılları arasında prostat kanseri tanısı ile radyoterapi uygulanan 59 hastanın patoloji preparatlarında IGF-IR ekspresyonu immunhistokimyasal yöntemle çalışıldı. Medyan yaş 73 (56-83) ve izlem süresi 48.3 aydı. Hastaların 43’ünde (73%) IGF-IR ekspresyonu mevcuttu. Tek değişkenli analiz sonucunda biyokimyasal hastalıksız sağ kalım, IGF-IR ekspresyonu olan, 70 yaşından küçük, Gleason skoru 8’in altında, PSA0 değeri 20 ng/ml’nin altında olan hastalarda daha uzundu. Çok değişkenli analiz sonucunda PSA0 değerinin 20 ng/ml’nin ve PSA2 değerinin de 0.36 ng/ml’nin altında olması biyokimyasal hastalıksız sağ kalım açısından önemli bulundu. 4 yıllık genel sağ kalım %76, biyokimyasal hastalıksız sağ kalım %80, metastazsız sağ kalım ise %93’dür. Bu çalışma sonucunda, IGF-IR ekspresyonu olan hastalarda biyokimyasal hastalıksız sağ kalımın daha uzun olduğu görüldü.

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Cite This Article

KORCUM, A., TEKELİ, E., AKSU, M. G., ERDOĞAN, G., ÇİFTÇİOĞLU, A. (2009). The prognostic significance of the expression of insulin-like growth factor receptor-I in prostate cancer. Uluslararası Hematoloji-Onkoloji Dergisi, Cilt: 19 - Sayı: 4, 223–231. https://ajindex.com/articles/323077

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