SavedAdd your journal

Journals / SSK İzmir Eğitim Hastanesi Tıp Dergisi / 2004 / Cilt: 10 - Sayı: 4

The prevalence of antithyroid and anticardiolipin antibodies in the patients who have type 1 diabetes and its relation with the complications of diabetes

Tip 1 diyabetes mellitus'lu hastalarda tiroid otoantikor ve antikardiolipin antikor sıklığı ve diyabetik komplikasyonlarla ilişkisi

Doğan ÖZKAN
A. YILDIRIM
Seda DEMİREL
Metin AKINCILAR
Tuğba GÜMÜŞ
Şermin ŞENEL
Gülten SOP
Pages
173–176
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Thyroid autoantibodies and AKA prevalence was assessed to be higher positive compared to the normal population.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Type I diabetes mellitus has an autoimmune base thus it can be diagnosed along with the other autoimmune diseases.
📊
Key Findings & Data:Evaluated parameters obtained from the 16 female and 4 male totally 20 patients were; the blood chemistry, HbA1c, HLADR3, HLADR4, anti-GAD, AiA, anti-T, anti-M, AKA IgG, AKA IgM.
💡
Conclusion & Impact:Thyroid autoantibodies and AKA prevalence was assessed to be higher positive compared to the normal population.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antikorlar · Antikorlar · antikardiyolipin

Abstract

Type I diabetes mellitus has an autoimmune base thus it can be diagnosed along with the other autoimmune diseases. In this study we assessed the thyroid autoimmune antibodies and AKA prevalence and their relations with the complications of diabetes. Evaluated parameters obtained from the 16 female and 4 male totally 20 patients were; the blood chemistry, HbA1c, HLADR3, HLADR4, anti-GAD, AiA, anti-T, anti-M, AKA IgG, AKA IgM. Among these 20 patients evaluated; AiA 40%, anti-GAD 15%, HLADR3 25%, HLADR4 30%, anti-T anti-M 20%, AKA IgM 30%, AKA IgG 5% were positive. The mean ratio of the HgA1c was 10.94.Neither the HLA system nor the AKA had been assessed to relate with the thyroid autoantibodies. Similarly AKA and thyroid autoantibodies were not assessed to relate with diabetic complications. Thyroid autoantibodies and AKA prevalence was assessed to be higher positive compared to the normal population.

Özet

Tip 1 diyabetes Mellitus (DM) otoimmun bir hastalık olup diğer otoimmun hastalıklarla birlikteliği sıktır. Biz bu çalışmada tip 1 DM'lu hastalarda tiroid otoantikorlan ve antikardiolipin antikor (AKA) sıklığı ile bunların diyabetik komplikasyonlarla ilişkisini araştırdık.Tip 1 DM'lu 16'sı kadın, 4'ü erkek toplam 20 olgu çalışmaya alınarak, kan biyo¬kimyaları, HbA1C, HLA DR3, HLA DR4, anti GAD, Anti insülin antikor (AlA), tiroid oto- antikor (anti T, anti M) değerleri ölçüldü. Hastaların HbA1c ortalamaları :%10.94 olup, 20 olgunun 8'inde (%40) Al A, %15'inde anti GAD , %25'inde HLA DR3, %30'unda HLA DR4, %20'sinde anti T ve anti M, %30'unda AKA IgM, %5'inde AKA IgG'yi po- zitif saptadık. HLA sistemi ile tiroid otoantikor ve AKA arasında ,AKA ve tiroid otoan- tikorları ile diyabet komplikasyonları arasında ilişki saptamadık. Tipi DM'lu hastalarda tiroid otoantikor ve AKA düzeylerini normal populasyona göre daha yüksek oranda pozitif saptadık.

🔖

Cite This Article

ÖZKAN, D., YILDIRIM, A., DEMİREL, S., AKINCILAR, M., GÜMÜŞ, T., ŞENEL, Ş., SOP, G. (2004). The prevalence of antithyroid and anticardiolipin antibodies in the patients who have type 1 diabetes and its relation with the complications of diabetes. SSK İzmir Eğitim Hastanesi Tıp Dergisi, Cilt: 10 - Sayı: 4, 173–176. https://ajindex.com/articles/313049

References (6)

  1. Büyükdevrim AS. Tip 1 diyabette etiyoloji ve patogenez: Diabetes Mellitus 1. İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü Yayınları 1989, 101-258 2. Jenkins D.Genetics of type 1 diabetes mellitus. Diabetes Reviews 3 (2)
  2. 7,1994 3. Nepam GT. İmmunogenetics and IDDM. Diabetes Reviews 1(1)
  3. 104, 1992 4. Rossini AA. immunopathogenesis of diabetes mellitus. Diabetes Reviews 1(1)
  4. 15,1992 5. Wilson JD, Foster DW. Genetics and etiology of type 1 insulin-dependent diabetes mellitus Williams Textbook of Endocrinology 8 th Edition. WB Saunders Company 1993, 1257-1268 6. Hughes GRV, Harris EN, Ghorovi AE. The antikardiolipin syndrom. J Rheumatol, 13 (3)
  5. 89,1986. 7. Alarco+Segovia D. Clinical manifestations of Antiphospholipid Syndrome. J Rheumatol 19: 177-81,1992 8. Galli M, Finozzi G, Bevers EN et al.Antiphospholipid Syndrome: advances in pathophysiology and treatment. J Nephrol 8 (4)
  6. 90, 1995 9. Larsen PR, ingbor H. The thyroid gland. William's Textbook of Endocrinology. WB Saunders Comp. 8 th Edition. 1992, 358-487 10. The Diabetes Control and Complications Trial (DCCT) Research Group. The effect of intensive treatment of diabetes on the develeopment and progression of long term complications in insülin dependent diabetes mellitus. N Eng J Med. 329:977-986, 1993 11. UK Prospective Diabetes Study (UKPDS) Group. Thigt blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. BMJ 317:703-713,1998 12. Ahmet E, Nityan S, Mustafa A et al.Anticardiolipin antibodies and circulating immune complex in type 1 diabetes mellitus increased prevalance and relation to vascular complications. Clinical Exp immunol 115 (2): 255-59, 1995 13. Gorgilo P, Goldberg J, Romani B et al. Qualitative and quantitative studies of autoantibodies to phospholipids in diabetes mellitus. Clinical Exp immunol 118:30-34, 1999 14. Khaashta A, Hughess GRV. Antiphospholipid antibodies and anti-phospholipid syndrome. Current Opinion in Rheumatology 7: 389-94, 1995 15. Bucolo R, Cerami A. Advanced glycosylation: chemisty biology and implications for diabetes and aging. Adv Pharmacol 23: 1- 34, 1992 16. Lackshin MD. Antiphospholipid Antibody Syndrome. JAMA 268 (11): 1451-53,1992 17. Guissepe A, Roberto C, Renata L. Anticardiolipin antibodies in children and adolescents with insulin dependent diabetes mellitus. Diabetes Research and Clinical Practice 23: 63-64, 1994 18. Anzai K, Nakamura M, Magafuchi S et al. Production of anti-cardiolipin a