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Journals / Records of Natural Products / 2018 / Cilt: 12 - Sayı: 3

Inhibition of Various Cancer Cells Proliferation of Bornyl Acetate and Essential Oil from Inula graveolens (Linnaeus) Desf

Tünay KARAN
İlyas YILDIZ
Ali AYDIN
RAMAZAN ERENLER
Pages
273–283
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Essential oil and bornyl acetate displayed the outstanding activities on HeLa (IC50, 64.1, 72.0 µg/mL), HT29 (IC50, 24.6, 60.5 µg/mL), A549 (IC50, 28.3, 44.1 µg/mL), MCF-7 (IC50, 66.5, 85.6 µg/mL), and FL (IC50, 42.1, 50.6 µg/mL) cell lines respectively

📌 3 Key Takeaways

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Objective & Hypothesis:Inula species are medicinal and aromatic plants used for folk medicine extensively.
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Key Findings & Data:In this work, hydrodistilled essential oil of Inula graveolens (Linnaeus) Desf. analyzed by GC-MS which revealed that bornyl acetate was the major product (69.15%).
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Conclusion & Impact:Essential oil and bornyl acetate displayed the outstanding activities on HeLa (IC50, 64.1, 72.0 µg/mL), HT29 (IC50, 24.6, 60.5 µg/mL), A549 (IC50, 28.3, 44.1 µg/mL), MCF-7 (IC50, 66.5, 85.6 µg/mL), and FL (IC50, 42.1, 50.6 µg/mL) cell lines respectively
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Inula species are medicinal and aromatic plants used for folk medicine extensively. In this work, hydrodistilled essential oil of Inula graveolens (Linnaeus) Desf. analyzed by GC-MS which revealed that bornyl acetate was the major product (69.15%). Camphene was the second major compound (11.11%). Antiproliferative activity of the essential oil and bornyl acetate was investigated on HeLa (human cervix carcinoma), HT29 (human colon carcinoma), A549 (human lung carcinoma), MCF7 (human breast adenocarcinoma) cancer cells and FL (human amnion cells) normal cells. The cytotoxicity was executed by a Lactate Dehydrogenase (LDH) Cytotoxicity Detection Kit. Essential oil and bornyl acetate displayed the outstanding activities on HeLa (IC50, 64.1, 72.0 µg/mL), HT29 (IC50, 24.6, 60.5 µg/mL), A549 (IC50, 28.3, 44.1 µg/mL), MCF-7 (IC50, 66.5, 85.6 µg/mL), and FL (IC50, 42.1, 50.6 µg/mL) cell lines respectively

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Cite This Article

KARAN, T., YILDIZ, İ., AYDIN, A., ERENLER, R. (2018). Inhibition of Various Cancer Cells Proliferation of Bornyl Acetate and Essential Oil from Inula graveolens (Linnaeus) Desf. Records of Natural Products, Cilt: 12 - Sayı: 3, 273–283. https://ajindex.com/articles/308642

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