The α-glucosidase inhibitory activity of compounds 1- 5 was evaluated using α-glucosidase inhibitory assay, in which all compounds displayed good inhibitory activity with IC50 values ranging from 4.2 ~ 36.2 μM.
📌 3 Key Takeaways
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Objective & Hypothesis:A new polyacetylene, heptadeca-8,16-dien-4,6-diyn-3,l0-diol (1) along with four known polyacetylenes, 1,2-dihydrodendroarboreol B (2), heptadeca-1,8-dien-4,6-diyn-3,l0-diol (3), 3R, 8S-falcarindiol (4) and 3R,8R-dehydrofalcarindiol (5) were isolated from the ethanol extract of Aralia dumetorum.
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Key Findings & Data:The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectrums and by comparison of the spectroscopic data with those reported for structurally related compounds.
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Conclusion & Impact:The α-glucosidase inhibitory activity of compounds 1- 5 was evaluated using α-glucosidase inhibitory assay, in which all compounds displayed good inhibitory activity with IC50 values ranging from 4.2 ~ 36.2 μM.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
A new polyacetylene, heptadeca-8,16-dien-4,6-diyn-3,l0-diol (1) along with four known polyacetylenes, 1,2-dihydrodendroarboreol B (2), heptadeca-1,8-dien-4,6-diyn-3,l0-diol (3), 3R, 8S-falcarindiol (4) and 3R,8R-dehydrofalcarindiol (5) were isolated from the ethanol extract of Aralia dumetorum. The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectrums and by comparison of the spectroscopic data with those reported for structurally related compounds. The α-glucosidase inhibitory activity of compounds 1- 5 was evaluated using α-glucosidase inhibitory assay, in which all compounds displayed good inhibitory activity with IC50 values ranging from 4.2 ~ 36.2 μM.
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Cite This Article
JIANG, M., YANG, C., PU, X., FU, G., WANG, W., LI, Y., FENG, L., NIU, Z., TAN, J., HUANG, X. (2019). Polyacetylenes from the Roots of Aralia dumetorum. Records of Natural Products, Cilt: 13 - Sayı: 5, 424–428. https://ajindex.com/articles/308627
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