To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea
📌 3 Key Takeaways
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Objective & Hypothesis:Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384.
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Key Findings & Data:Of these isolates, 1 showed moderate NO inhibitory activity with an IC50value of 60.0 μM.
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Conclusion & Impact:To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC50value of 60.0 μM. Compound 1 also showed the androgen receptor (AR) antagonism with the IC50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea
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Cite This Article
YANG, S., CHENG, M., CHAN, H., HSİEH, S., WU, H., YUAN, G., LİN, C., CHANG, H., CHEN, I. (2017). New Secondary Metabolites from an Endophytic Fungus in Porodaedalea pini. Records of Natural Products, Cilt: 11 - Sayı: 3, 251–269. https://ajindex.com/articles/308351
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