Objective & Hypothesis:Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of two new isochromene derivatives namely, 6,8-dimethoxy-3-methyl3,4-dihydrobenzoisochromene-4,9,10-triol (1) and 3,5,6-trihydroxy-4-methylbenzoisochromene-9,11-dione (2) along with four known compounds (3-6).
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Key Findings & Data:The structures of these compounds were elucidated by 1D and 2D NMR and mass spectroscopic data analysis.
Phytochemical investigation on pathogenic fungus Cylindrocarpon destructans isolated form Meconopsisgrandis plant led to the isolation of two new isochromene derivatives namely, 6,8-dimethoxy-3-methyl3,4-dihydrobenzoisochromene-4,9,10-triol (1) and 3,5,6-trihydroxy-4-methylbenzoisochromene-9,11-dione (2) along with four known compounds (3-6). The structures of these compounds were elucidated by 1D and 2D NMR and mass spectroscopic data analysis. The isolated compounds were evaluated for cytotoxic activity. The compounds 1-4 showed good inhibition against the growth of cell lines MCF-7 and PC-3. Compounds 5-6 showed minimum inhibitory effect of cancerous cell lines growth.
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Cite This Article
KHAN, D., NİAZ, S. I., TAHİR, K., KHAN, H., HAROON, M., KHAN, S. U., BADSHAH, S., KHAN, S., JABEEN, M., LAN, L. (2019). New Cytotoxic Metabolites from Pathogenic Fungus Cylindrocarpon destructans Associated with Meconopsis grandis. Records of Natural Products, Cilt: 13 - Sayı: 2, 129–135. https://ajindex.com/articles/308263
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