Compounds 2, 4 and 5 showed potential inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.
📌 3 Key Takeaways
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Objective & Hypothesis:Fifteen phenylpropanoids were isolated from the ethanol extract of Solanum melongena L. roots, including a new compound, melongenapanoid A (1), and fourteen known compounds (2-15) were isolated from the species.
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Key Findings & Data:Their chemical structures were elucidated by interpreting the 1D and 2D NMR and HR-MS data as well as in comparison with the literature.
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Conclusion & Impact:Compounds 2, 4 and 5 showed potential inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Fifteen phenylpropanoids were isolated from the ethanol extract of Solanum melongena L. roots, including a new compound, melongenapanoid A (1), and fourteen known compounds (2-15) were isolated from the species. Their chemical structures were elucidated by interpreting the 1D and 2D NMR and HR-MS data as well as in comparison with the literature. The anti-inflammatory activities of isolates were evaluated by measuring their inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 cell line. Compounds 2, 4 and 5 showed potential inhibition of NO production with IC50 values of 28.7, 24.4 and 32.6 μM, respectively.
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Cite This Article
LIU, Y., YIN, X., SUN, Y., LIU, Y., LU, D., ZHOU, Y., ADNAN, M. A., PAN, J., GUAN, W., YANG, B., KUANG, H. (2021). A New Phenylpropanoid from the Roots of Solanum melongena L. and Evaluation of Anti-inflammatory Activity. Records of Natural Products, Cilt: 15 - Sayı: 4, 261–266. https://ajindex.com/articles/308184
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